[Variant of the Hodgkin-Huxley model with a reduced number of parameters]. / Variant modeli Khodzhkina-Khaksli s sokrashchennym chislov parametrov.

The time constants of variations in sodium and potassium conductances of neural cell membrane have been investigated as a function of transmembrane potential. It is shown that the dependences can be described by the model of self-organization and self-regulation in open dynamic systems reported early. This approach has two advantages over the empirical formulae by Hodgkin and Huxley: 1) the number of parameters to be defined is substantially reduced, which simplifies modeling of real cells, and 2) the model involves a particular mechanisms by which the transmembrane potential regulates the time constants of variations in membrane conductance, which can promote further development of theoretical conceptions of the action potential generation process.

[Morpho-biochemical study of catecholamine metabolism in the myocardium of dogs with fibrillation and autolysis]. / Morfobiokhimicheskoe issledovanie obmena katekholaminov v miokarde sobak pri fibrilliatsii i autolize.

The balance of catecholamines (CA) and their metabolites in the canine heart during myocardial fibrillation and 1, 2, 3, 4, 5, 6 hours after death was studied. The fibrillation was caused by low myocardial electrostimulation. The comparative neuro-morphometric analysis of the CA-containing structures in 1 and 5 min of the fibrillation and the determination of the norepinephrine, its precursors and metabolites by HPLC-ED method was done. There was an increase of the myocardial norepinephrine (20%), 3-4-dihydroxyphenylethyleneglycol (25%) and decrease of the dopamine (50%) contents without any qualitative changes of CA metabolism. Autolysis leads to the successive decrease of the norepinephrine and dopamine contents without any qualitative changes of the CA metabolism too. These data suggest that autopsies could be used for the determination of the myocardial CA content and the qualitative characteristics of the CA metabolism before death in those who died suddenly.

[Determination of monoamines and 10 of their metabolites in the brain and heart of the rat by high-pressure liquid chromatography with electrochemical detection]. / Opredelenie monoaminov i 10 ikh metabolitov v mozge i serdtse krysy metodom zhidkostnoi khromatografii vysokogo davleniia s élektrokhimicheskoi detektsiei.

The adequate parameters for simultaneous determination of more than 10 monoamines, their precursors and metabolites (noradrenaline, 3-methoxy-4-hydroxyphenylglycol, 3,4-dihydrooxyphenylglycol++, vanylylmandelic acid, normetanephrine, adrenaline, metanephrine, dopamine, 3-methoxytytramine, 3,4-dihydroxphenylacetic acid, 3,4-dihydroxyphenylalanine, 5-hydroxytryptophane, 5-hydroxyindolacetic acid) by liquid chromatography with electro-chemical detection were suggested for the rat brain and heart. The influence of reserpine, iproniazid, and imipramine on the content of the changes of monoamines and their metabolite levels in the rat brain and heart were also investigated.