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1.
J Clin Neurophysiol ; 40(5): 462-464, 2023 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-34817443

RESUMO

PURPOSE: The cardinal symptoms of carpal tunnel syndrome (CTS) include pain in the affected hand(s). The median/second lumbrical nerve (Med2ndL) seems relatively preserved in severe CTS, with previous small studies suggesting its value in electromyogram to localize a median neuropathy to the wrist when both initial routine sensory and thenar motor responses are absent. METHODS: This is a retrospective analysis of 208 hands in 183 patients with electrophysiologically markedly severe CTS (absent routine sensory and thenar motor median responses) who underwent stimulation of both the Med2ndL and ulnar/second dorsal interosseous (Uln2ndDIn) motor nerves. A Med2ndL distal latency of ≥ 0.5 milliseconds when compared with the Uln2ndDIn supported the diagnosis of CTS. The presence or absence of hand pain was recorded if these data were available. RESULTS: Some 83.7% of hands (172/208) in 183 patients with markedly severe CTS had preservation of the Med2ndL meeting criteria for CTS. In those with pain data available, 77.1% (81/105) of hands had no pain. Of those 105 hands, 87 had preservation of the Med2ndL with 79.3% (69/87) demonstrating no pain. CONCLUSIONS: This is a large study that demonstrates the relative preservation of the Med2ndL response in markedly severe CTS. Assessment of the Med2ndL should be considered to electrophysiologically support CTS when routine sensory and thenar motor responses are absent. In addition, most patients with electrophysiologically markedly severe CTS had no pain.


Assuntos
Síndrome do Túnel Carpal , Humanos , Síndrome do Túnel Carpal/diagnóstico , Estudos Retrospectivos , Condução Nervosa/fisiologia , Nervo Ulnar/fisiologia , Nervo Mediano
2.
Clin Neurophysiol ; 131(7): 1662-1663, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32354605

RESUMO

Modern neuromuscular electrodiagnosis (EDX) and neuromuscular ultrasound (NMUS) require a universal language for effective communication in clinical practice and research and, in particular, for teaching young colleagues. Therefore, the AANEM and the IFCN have decided to publish a joint glossary as they feel the need for an updated terminology to support educational activities in neuromuscular EDX and NMUS in all parts of the world. In addition NMUS has been rapidly progressing over the last years and is now widely used in the diagnosis of disorders of nerve and muscle in conjunction with EDX. This glossary has been developed by experts in the field of neuromuscular EDX and NMUS on behalf of the AANEM and the IFCN and has been agreed upon by electronic communication between January and November 2019. It is based on the glossaries of the AANEM from 2015 and of the IFCN from 1999. The EDX and NMUS terms and the explanatory illustrations have been updated and supplemented where necessary. The result is a comprehensive glossary of terms covering all fields of neuromuscular EDX and NMUS. It serves as a standard reference for clinical practice, education and research worldwide.


Assuntos
Eletromiografia/normas , Neurologia/normas , Terminologia como Assunto , Ultrassonografia/normas , Eletromiografia/métodos , Neurologia/organização & administração , Guias de Prática Clínica como Assunto , Sociedades Médicas/normas , Ultrassonografia/métodos
3.
Muscle Nerve ; 62(1): 10-12, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32337730

RESUMO

Modern neuromuscular electrodiagnosis (EDX) and neuromuscular ultrasound (NMUS) require a universal language for effective communication in clinical practice and research and, in particular, for teaching young colleagues. Therefore, the AANEM and the IFCN have decided to publish a joint glossary as they feel the need for an updated terminology to support educational activities in neuromuscular EDX and NMUS in all parts of the world. In addition NMUS has been rapidly progressing over the last years and is now widely used in the diagnosis of disorders of nerve and muscle in conjunction with EDX. This glossary has been developed by experts in the field of neuromuscular EDX and NMUS on behalf of the AANEM and the IFCN and has been agreed upon by electronic communication between January and November 2019. It is based on the glossaries of the AANEM from 2015 and of the IFCN from 1999. The EDX and NMUS terms and the explanatory illustrations have been updated and supplemented where necessary. The result is a comprehensive glossary of terms covering all fields of neuromuscular EDX and NMUS. It serves as a standard reference for clinical practice, education and research worldwide. HIGHLIGHTS: Optimal terminology in neuromuscular electrodiagnosis and ultrasound has been revisited. A team of international experts have revised and expanded a standardized glossary. This list of terms serves as standard reference for clinical practice, education and research.


Assuntos
Dicionários como Assunto , Eletrodiagnóstico/classificação , Doenças Neuromusculares/classificação , Doenças Neuromusculares/diagnóstico por imagem , Sociedades Médicas/classificação , Ultrassonografia/classificação , Humanos , Estados Unidos
4.
Artigo em Inglês | MEDLINE | ID: mdl-31604776

RESUMO

Mitochondrial disorders are caused by nuclear and mitochondrial pathogenic variants leading to defects in mitochondrial function and cellular respiration. Recently, the nuclear-encoded mitochondrial fusion gene MSTO1 (Misato 1) has been implicated in mitochondrial myopathy and ataxia. Here we report on a 30-yr-old man presenting with a maternally inherited NM_018116.3:c.651C>G, p.F217L missense variant as well as a paternally inherited arr[GRCh37] 1q22(155581773_155706887) × 1 deletion encompassing exons 7-14 of MSTO1 His phenotype included muscle weakness, hypotonia, early motor developmental delay, pectus excavatum, and scoliosis. Testing revealed elevated plasma creatine kinase, and electromyogram results were consistent with longstanding generalized myopathy. These phenotypic features overlap well with previously reported patients harboring biallelic MSTO1 variants. Additionally, our patient presents with dysphagia and restrictive lung disease, not previously reported for MSTO1-associated disorders. The majority of patients with disease-associated variants in MSTO1 present with biallelic variants suggesting autosomal recessive inheritance; however, one family has been reported with a single variant and presumed autosomal dominant inheritance. The pattern of inheritance we observed is consistent with the majority of previous reports suggesting an autosomal recessive disorder. We add to our knowledge of the syndrome caused by variants in MSTO1 and provide additional evidence supporting autosomal recessive inheritance. We also describe phenotypic features not reported in previous cases, although further research is needed to confirm they are associated with defects in MSTO1.


Assuntos
Proteínas de Ciclo Celular/genética , Proteínas do Citoesqueleto/genética , Miopatias Mitocondriais/genética , Adulto , Alelos , Ataxia/genética , Proteínas de Ciclo Celular/metabolismo , Proteínas do Citoesqueleto/metabolismo , Família , Humanos , Masculino , Mitocôndrias/genética , Doenças Mitocondriais/genética , Doenças Mitocondriais/metabolismo , Miopatias Mitocondriais/metabolismo , Doenças Musculares/genética , Mutação , Linhagem , Fenótipo
5.
Am J Med Genet A ; 176(12): 2846-2849, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30549423

RESUMO

Exome sequencing is being used increasingly to evaluate patients with intellectual disability. YY1 is a ubiquitously distributed transcription factor belonging to the GLIKruppel class of zinc finger proteins recently recognized as the causative gene in 23 patients for the Gabriele-de Vries syndrome. We report a new case with similar features and a novel variant in YY1, in a region of the gene, which has not previously been reported. A 25 year old female was referred to clinical genetics with a diagnosis of autoimmune myasthenia gravis, facial dysmorphism and learning disability. Chromosomal microarray and gene panel test for congenital myasthenic syndrome was negative. Whole exome sequencing (WES) revealed a presumed pathogenic de novo novel, heterozygous, truncating variant in the YY1 gene, c.860_864delTTAAAA, p.Ile287Argfs*3. The Ile287 residue is conserved across species and is situated in the transcription repressor domain of the protein. This variant is novel and lies in a domain of the protein where no previously reported variants occur. The phenotypic features of our case closely match those of the reported patients. Autoimmune myasthenia gravis has not been reported in these patients and may constitute an expansion of this phenotypic spectrum or perhaps more likely a second unrelated diagnosis.


Assuntos
Estudos de Associação Genética , Deficiências da Aprendizagem/diagnóstico , Deficiências da Aprendizagem/genética , Miastenia Gravis/complicações , Fator de Transcrição YY1/genética , Adulto , Biomarcadores , Aberrações Cromossômicas , Fácies , Feminino , Heterozigoto , Humanos , Miastenia Gravis/diagnóstico , Fenótipo , Radiografia Torácica , Síndrome , Tomografia Computadorizada por Raios X , Sequenciamento do Exoma
7.
J Clin Neurophysiol ; 35(1): 59-64, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29298213

RESUMO

Multiple techniques have been developed for the electrodiagnostic evaluation of cranial nerves XI and XII. Each of these carries both benefits and limitations, with more techniques and data being available in the literature for spinal accessory than hypoglossal nerve evaluation. Spinal accessory and hypoglossal neuropathy are relatively uncommon cranial mononeuropathies that may be evaluated in the outpatient electrodiagnostic laboratory setting. A review of available literature using PubMed was conducted regarding electrodiagnostic technique in the evaluation of spinal accessory and hypoglossal nerves searching for both routine nerve conduction studies and repetitive nerve conduction studies. The review provided herein provides a resource by which clinical neurophysiologists may develop and implement clinical and research protocols for the evaluation of both of these lower cranial nerves in the outpatient setting.


Assuntos
Nervo Acessório/fisiologia , Eletrodiagnóstico , Nervo Hipoglosso/fisiologia , Nervo Acessório/anatomia & histologia , Nervo Acessório/fisiopatologia , Eletrodiagnóstico/métodos , Humanos , Nervo Hipoglosso/anatomia & histologia , Nervo Hipoglosso/fisiopatologia
8.
Muscle Nerve ; 56(2): 242-246, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-27859367

RESUMO

INTRODUCTION: Recurrent complete ulnar nerve dislocation has been perceived as a risk factor for development of ulnar neuropathy at the elbow (UNE). However, the role of dislocation in the pathogenesis of UNE remains uncertain. METHODS: We studied 133 patients with complete ulnar nerve dislocation to determine whether this condition is a risk factor for UNE. In all, the nerve was palpated as it rolled over the medial epicondyle during elbow flexion. RESULTS: Of 56 elbows with unilateral dislocation, UNE localized contralaterally in 17 elbows (30.4%) and ipsilaterally in 10 elbows (17.9%). Of 154 elbows with bilateral dislocation, 26 had UNE (16.9%). Complete dislocation decreased the odds of having UNE by 44% (odds ratio = 0.475; P = 0.028), and was associated with less severe UNE (P = 0.045). CONCLUSIONS: UNE occurs less frequently and is less severe on the side of complete dislocation. Complete dislocation may have a protective effect on the ulnar nerve. Muscle Nerve 56: 242-246, 2017.


Assuntos
Articulação do Cotovelo/inervação , Luxações Articulares/fisiopatologia , Nervo Ulnar/fisiopatologia , Neuropatias Ulnares/complicações , Idoso , Distribuição de Qui-Quadrado , Eletromiografia , Feminino , Lateralidade Funcional/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Condução Nervosa/fisiologia , Estudos Retrospectivos , Punho/inervação
9.
Muscle Nerve ; 54(6): 1050-1054, 2016 12.
Artigo em Inglês | MEDLINE | ID: mdl-27214783

RESUMO

INTRODUCTION: Apart from a case series of 100 subjects in 1996 and several small cohorts, there have been no large retrospective series of cranial nerve XII (CN XII) palsy. METHODS: From 1984 to 2014, 245 cases of CN XII palsy were identified via retrospective chart review using historical and exam findings that confirmed the diagnosis. In addition to clinical characteristics, univariate and multivariate models were investigated to predict neoplastic CN XII palsy. RESULTS: Major etiologic categories included: postoperative (29.3%), idiopathic (15.1%), primary neoplastic (14.2%), metastatic malignancy (13.0%), inflammatory (7.3%), radiation (6.1%), and traumatic (4.1%). A multivariate model revealed male gender and a personal history of cancer as predictive of neoplastic CN XII palsy. CONCLUSIONS: The most frequent etiologies and disease categories of CN XII palsy were identified, and male gender and personal history of cancer were found to be predictive of a neoplastic cause of CN XII palsy. Muscle Nerve 54: 1050-1054, 2016.


Assuntos
Doenças do Nervo Hipoglosso/etiologia , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Feminino , Humanos , Doenças do Nervo Hipoglosso/diagnóstico , Masculino , Pessoa de Meia-Idade , Neoplasias/complicações , Complicações Pós-Operatórias/fisiopatologia
10.
Muscle Nerve ; 54(3): 371-7, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-27238640

RESUMO

INTRODUCTION: To address the need for greater standardization within the field of electrodiagnostic medicine, the Normative Data Task Force (NDTF) was formed to identify nerve conduction studies (NCS) in the literature, evaluate them using consensus-based methodological criteria derived by the NDTF, and identify those suitable as a resource for NCS metrics. METHODS: A comprehensive literature search was conducted of published peer-reviewed scientific articles for 11 routinely performed sensory and motor NCS from 1990 to 2012. RESULTS: Over 7,500 articles were found. After review using consensus-based methodological criteria, only 1 study each met all quality criteria for 10 nerves. CONCLUSION: The NDTF selected only those studies that met all quality criteria and were considered suitable as a clinical resource for NCS metrics. The literature is, however, limited and these findings should be confirmed by larger, multicenter collaborative efforts. Muscle Nerve 54: 371-377, 2016.


Assuntos
Eletrodiagnóstico , Extremidade Inferior/inervação , Condução Nervosa/fisiologia , Nervos Periféricos/fisiologia , Extremidade Superior/inervação , Potenciais de Ação/fisiologia , Adulto , Fatores Etários , Idoso , Bases de Dados Bibliográficas/estatística & dados numéricos , Estimulação Elétrica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Exame Neurológico , Valores de Referência , Estudos Retrospectivos
11.
Muscle Nerve ; 54(3): 366-70, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-27238858

RESUMO

INTRODUCTION: There are not uniform standards for nerve conduction testing across the United States. The objective of this study is to present a set of methodologically sound criteria to evaluate the literature for the purpose of identifying high-quality normative nerve conduction studies (NCS) suitable for widespread use. METHODS: The Normative Data Task Force (NDTF) was formed to review published studies on methodological issues related to NCS. A set of criteria was then developed to evaluate the literature. These criteria and their rationale are described. RESULTS: We identified 7 key issues that reflect high quality in NCS. For each issue, specific review criteria were developed. CONCLUSION: Rigorous criteria enable identification of high-quality studies dealing with nerve conduction reference values. This represents the first step toward the overarching goal of recommending NCS techniques and reference values for electrodiagnostic medicine. Muscle Nerve 54: 366-370, 2016.


Assuntos
Comitês Consultivos/normas , Esclerose Lateral Amiotrófica/diagnóstico , Condução Nervosa/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Esclerose Lateral Amiotrófica/fisiopatologia , Bases de Dados Factuais , Eletromiografia/métodos , Eletromiografia/normas , Feminino , Corpo Humano , Humanos , Masculino , Pessoa de Meia-Idade , Exame Neurológico , Valores de Referência , Estudos Retrospectivos , Medula Espinal/fisiopatologia , Estados Unidos , Adulto Jovem
12.
Pain ; 157(5): 1156-1163, 2016 May.
Artigo em Inglês | MEDLINE | ID: mdl-26907092

RESUMO

There has been a significant increase over recent years in the use of contact heat evoked potentials (CHEPs) for the evaluation of small nerve fiber function. Measuring CHEP amplitude and latency has clinical utility for the diagnosis and assessment of conditions with neuropathic pain. This international multicenter study aimed to provide reference values for CHEPs to stimuli at 5 commonly examined body sites. Contact heat evoked potentials were recorded from 226 subjects (114 females), distributed per age decade between 20 and 79 years. Temperature stimuli were delivered by a thermode (32°C-51°C at a rate of 70°C/s). In phase I of the study, we investigated side-to-side differences and reported the maximum normal side-to-side difference in Aδ CHEP peak latency and amplitude for leg, forearm, and face. In phase II, we obtained normative data for 3 CHEP parameters (N2P2 amplitude, N2 latency, and P2 latency), stratified for gender and age decades from face, upper and lower limbs, and overlying cervical and lumbar spine. In general, larger CHEP amplitudes were associated with higher evoked pain scores. Females had CHEPs of larger amplitude and shorter latency than males. This substantive data set of normative values will facilitate the clinical use of CHEPs as a rapid, noninvasive, and objective technique for the assessment of patients presenting with neuropathic pain.


Assuntos
Potenciais Somatossensoriais Evocados/fisiologia , Temperatura Alta , Neuralgia/fisiopatologia , Adulto , Fatores Etários , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neuralgia/diagnóstico , Estimulação Física , Tempo de Reação/fisiologia , Valores de Referência , Fatores Sexuais , Adulto Jovem
13.
Muscle Nerve ; 53(3): 351-62, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26112058

RESUMO

INTRODUCTION: The aim of this study was to create reference values for jitter measured with concentric needle electrodes. METHODS: Operators worldwide contributed recordings from orbicularis oculi (OO), frontalis (FR), and extensor digitorum (ED) muscles in healthy controls. Criteria for acceptable signal quality were agreed upon in advance. Fifteen or 20 recordings of acceptable quality from each muscle were required for voluntary and electrical stimulation recordings, respectively. RESULTS: Recordings from 59 to 92 subjects were obtained for each muscle and activation type. Outlier limits for mean consecutive difference and individual jitter data for voluntary activation were: OO, 31 and 45 µs; FR, 28 and 38 µs; ED, 30 and 43 µs; and for electrical stimulation they were: OO, 27 and 36 µs; FR, 21 and 28 µs; ED, 24 and 35 µs. CONCLUSION: Reference jitter values from concentric needle electrode recordings were developed from signals of defined quality while seeking to avoid creating supernormal values.


Assuntos
Eletrodos , Potenciais Evocados/fisiologia , Músculo Esquelético/fisiologia , Junção Neuromuscular/fisiologia , Adulto , Biofísica , Estimulação Elétrica , Eletromiografia , Humanos , Pessoa de Meia-Idade , Valores de Referência , Estatística como Assunto
15.
Handb Clin Neurol ; 126: 31-43, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25410212

RESUMO

Of the many patterns of peripheral nerve disorders in diabetes mellitus (DM), isolated clinical involvement of single nerves, though less common than distal symmetric polyneuropathy and perhaps polyradiculoneuropathy, constitute an important collection of characteristic syndromes. These fall into four anatomical regions of the body: cranial, upper limb, truncal, and lower limb territories. Each of these groups of mononeuropathies has its own ensemble of epidemiologic patterns, clinical presentations, laboratory and radiologic findings, differential diagnosis, management principles and prognosis.


Assuntos
Diabetes Mellitus/diagnóstico , Nefropatias Diabéticas/diagnóstico , Síndromes de Compressão Nervosa/diagnóstico , Animais , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/terapia , Nefropatias Diabéticas/epidemiologia , Nefropatias Diabéticas/terapia , Diagnóstico Diferencial , Humanos , Síndromes de Compressão Nervosa/epidemiologia , Síndromes de Compressão Nervosa/terapia
16.
Aviat Space Environ Med ; 85(7): 700-7, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25022157

RESUMO

INTRODUCTION: Visual performance impairment after hypoxia is well recognized in military and civilian aviation. The aims of this study were: 1) to assess oculometric features such as blink metrics, pupillary dynamics, fixations, and saccades as cognitive indicators of early signs of hypoxia; and 2) to analyze the impact of different hypoxic conditions ["hypoxic hypoxia" (HH) and "isocapnic hypoxia" (IH)] on specified oculometrics during mental workloads. METHODS: Oculometric data were collected on 25 subjects under 3 conditions: normoxia, HH (8% O2 + balance N2), and IH (7% O2 + 5% CO2 + balance N2). The mental workload task consisted of reading aloud linear arrays of numbers after exposure to gas mixtures. RESULTS: Blink rates were significantly increased under hypoxic conditions (by +100.7% in HH and by +92.8% in IH compared to normoxia). A faster recovery of blink rate was observed in transitioning from IH (23.6% vs. 76.3%) to normoxia. The percentage change in pupil size fluctuation was increased under HH more than under IH (29% vs. 4.4%). Under HH average fixation time and target area size were significantly higher than under IH. Total saccadic times under hypoxic conditions were significantly increased compared with normoxia. CONCLUSIONS: These results suggest that oculometric changes are indicators of hypoxia, which can be monitored using compact, portable, noninvasive eye-tracking devices in a cockpit analogous environment to detect hypoxia-induced physiological changes in aircrew. Comparative results between HH and IH support the potential role of carbon dioxide in augmenting cerebral perfusion and hence improved tissue oxygen delivery.


Assuntos
Piscadela/fisiologia , Fixação Ocular/fisiologia , Hipóxia/fisiopatologia , Pupila/fisiologia , Movimentos Sacádicos/fisiologia , Adulto , Análise de Variância , Cognição/fisiologia , Feminino , Humanos , Masculino , Testes Neuropsicológicos , Projetos Piloto
17.
IEEE Trans Neural Syst Rehabil Eng ; 22(3): 511-21, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24760916

RESUMO

Evaluation of patients with suspected neuromuscular disorders is typically based on qualitative visual and auditory assessment of needle detected eletromyographic (EMG) signals; the resulting muscle characterization is subjective and highly dependent on the skill and experience of the examiner. Quantitative electromyography (QEMG) techniques were developed to extract motor unit potential trains (MUPTs) from needle detected EMG signals, and estimate features capturing motor unit potential (MUP) morphology and quantifying morphological consistency across MUPs belonging to the same MUPT. The aim of this study is to improve available methods for obtaining transparent muscle characterizations from features obtained using QEMG techniques. More specifically, we investigate the following. 1) Can the use of binarization mappings improve muscle categorization accuracies of transparent methods? 2) What are the appropriate binarization mappings in terms of accuracy and transparency? Results from four different sets of examined limb muscles (342 muscles in total) demonstrate that four out of the 10 investigated binarization mappings based on transparent characterization methods outperformed the multi-class characterizers based on Gaussian mixture models (GMM) and the corresponding binarization mappings based on GMM. This suggests that the use of an appropriate binarization mapping can overcome the decrease in categorization accuracy associated with quantizing MUPT features, which is necessary to obtain transparent characterizations. This performance gain can be attributed to the use of more relevant features and tuned quantization to obtain more specific binary characterizations.


Assuntos
Algoritmos , Eletromiografia/métodos , Músculo Esquelético/fisiopatologia , Extremidades/inervação , Extremidades/fisiologia , Humanos , Neurônios Motores , Fibras Musculares Esqueléticas , Doenças do Sistema Nervoso/diagnóstico , Doenças do Sistema Nervoso/fisiopatologia , Probabilidade , Reprodutibilidade dos Testes
18.
Neurology ; 82(19): 1745-8, 2014 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-24696504

RESUMO

Peripheral neuropathy is a common neurologic disorder, affecting 2% to 8% of the population in population-based studies with confirmation by neurologist examination. These prevalence numbers are remarkably stable across developed countries. In 1999, 8.6% of Medicare beneficiaries had neuropathy as a primary or secondary diagnosis, and the cost of treatment was estimated at $3.5 billion (Consumer Price Index adjusted to 2013 $4.9 billion), which did not include outpatient medications. Peripheral neuropathy has many causes and varies in regard to its clinical manifestations and severity. Distal symmetric polyneuropathy (DSP) is the most common pattern of peripheral neuropathy generally and the most common phenotype of neuropathy due to diabetes. Reported prevalence rates of DSP among diabetic patients range from 15% to 37% across large population-based studies, and the prevalence among those with impaired glucose tolerance has been reported to be 11%. DSP can result in weakness, sensory loss, pain, autonomic dysfunction, gait impairment, falls, disability, and impaired quality of life.


Assuntos
Doenças do Sistema Nervoso Periférico/diagnóstico , Qualidade da Assistência à Saúde/normas , Humanos , Neurologia/normas
19.
Muscle Nerve ; 49(5): 680-90, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-23893614

RESUMO

INTRODUCTION: Ten new features of motor unit potential (MUP) morphology and stability are proposed. These new features, along with 8 traditional features, are grouped into 5 aspects: size, shape, global complexity, local complexity, and stability. METHODS: We used sequential forward and backward search strategies to select subsets of these 18 features to discriminate accurately between muscles whose MUPs are predominantly neurogenic, myopathic, or normal. RESULTS AND CONCLUSIONS: Results based on 8102 motor unit potential trains (MUPTs) extracted from 4 different limb muscles (n = 336 total muscles) demonstrate the usefulness of these newly introduced features and support an aspect-based grouping of MUPT features.


Assuntos
Potenciais de Ação/fisiologia , Eletromiografia/métodos , Neurônios Motores/fisiologia , Músculo Esquelético/fisiologia , Doenças Neuromusculares/fisiopatologia , Processamento de Sinais Assistido por Computador , Algoritmos , Humanos , Análise Multivariada , Distribuição Normal
20.
Artigo em Inglês | MEDLINE | ID: mdl-25570885

RESUMO

OBJECTIVE: Motor unit loss associated with neuropathic disorders affects motor unit activation. Quantitative electromyographic (EMG) features of motor unit activation estimated from the sequences of motor unit potentials (MUPs) created by concurrently active motor units can support the detection of neuropathic disorders. Interpretation of most motor unit activation feature values are, however, confounded by uncertainty regarding the level of muscle activation during EMG signal detection. A set of new features circumventing these limitations are proposed, and their utility in detecting neuropathy is investigated using simulated and clinical EMG signals. METHODS: The firing sequence of a motor neuron was simulated using a compartmentalized Hodgkin-Huxley based model. A pool of motor neurons was modelled such that each motor neuron was subjected to a common level of activation. The detection of the firing sequence of a motor neuron using a clinically detected EMG signal was simulated using a model of muscle anatomy combined with a model representing muscle fiber electrophysiology and the voltage detection properties of a concentric needle electrode. SIGNIFICANCE: Findings are based on simulated EMG data representing 30 normal and 30 neuropathic muscles as well as clinical EMG data collected from the tibialis anterior muscle of 48 control subjects and 30 subjects with neuropathic disorders. These results demonstrate the possibility of detecting neuropathy using motor unit recruitment and mean firing rate feature values estimated from standard concentric needle detected EMG signals.


Assuntos
Eletromiografia/instrumentação , Neurônios Motores/fisiologia , Recrutamento Neurofisiológico/fisiologia , Algoritmos , Simulação por Computador , Eletrodos , Eletromiografia/métodos , Voluntários Saudáveis , Humanos , Perna (Membro)/fisiopatologia , Músculo Esquelético/fisiologia , Músculo Esquelético/fisiopatologia , Músculos , Agulhas , Doenças do Sistema Nervoso Periférico/diagnóstico
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