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1.
BMJ Open Respir Res ; 9(1)2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35705262

RESUMO

INTRODUCTION: Inducible laryngeal obstruction (ILO) describes transient laryngeal closure during respiration and can cause significant morbidity. Non-pharmacological behavioural therapy is the commonly cited treatment but efficacy is largely unknown. AIM: To synthesise the current evidence base on the effectiveness of non-pharmacological interventions used to treat adults with ILO. METHODS: Electronic databases (Medline/Embase/CINAHL/PsycINFO/AMED/CENTRAL) were systematically searched, informed by a population, intervention, comparison, outcome framework. Two reviewers independently screened a representative sample, with lead-author completion due to excellent inter-rater reliability. Data was extracted using a predefined piloted form. Methodological quality was appraised (blindly by two reviewers) using the Joanna Briggs Institute Critical Appraisal Tools. A narrative synthesis was performed due to heterogeneity of studies (PROSPERO registration number: CRD42020213187). RESULTS: Initial searching identified 3359 records. Full-text screening occurred in 92 records and 14 studies, comprising 527 participants, were deemed eligible. All studies were low-level evidence (observational by design, with four case reports), with a high risk of bias; none contained control arms for comparison. Intervention description was inconsistently and poorly described but direction of effect was positive in 76% of outcomes measured. The majority of studies showed a reduction in symptom scores and improved direct laryngeal imaging post intervention; there was an overall reduction, 59.5%, in healthcare utilisation. DISCUSSION: The literature is in an embryonic state and lacks robust data to truly inform on the effectiveness of non-pharmacological interventions used to treat adults with ILO. However, positive signals in the synthesis performed support non-pharmacological treatment approaches and further development is warranted.


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Doenças da Laringe , Adulto , Humanos , Doenças da Laringe/terapia
2.
Breathe (Sheff) ; 17(4): 210094, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35035566

RESUMO

Cough syncope is a rare but serious and potentially life-threatening complication of chronic cough. Early identification, comprehensive diagnostic evaluation and appropriate driving advice are fundamental to protect patients and the public. https://bit.ly/3CDAqYa.

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