Safety of maximal cardiopulmonary exercise testing in individuals with sickle cell disease: a systematic review.

OBJECTIVE: We evaluated the safety of maximal cardiopulmonary exercise testing (CPET) in individuals with sickle cell disease (SCD). Maximal CPET using gas exchange analysis is the gold standard for measuring cardiopulmonary fitness in the laboratory, yet its safety in the SCD population is unclear. DESIGN: Systematic review. DATA SOURCES: Systematic search of Medline (PubMed), EMBASE, Cochrane, ClinicalTrials.gov and professional society websites for all published studies and abstracts through December 2020. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Two reviewers independently extracted data of interest from studies that assessed safety outcomes of maximal CPET in children and adults with SCD. A modified version of the Newcastle-Ottawa Scale was used to assess for risk of bias in studies included. RESULTS: In total, 24 studies met inclusion/exclusion criteria. Adverse events were reported separately or as part of study results in 36 (3.8%) of 939 participants with SCD undergoing maximal CPET in studies included. Most adverse events were related to transient ischaemic changes on ECG monitoring or oxygen desaturation during testing, which did not result in arrhythmias or other complications. Only 4 (0.43%) of 939 participants experienced pain events due to maximal CPET. CONCLUSION: Maximal CPET appears to be a safe testing modality in children and adults with SCD and can be used to better understand the physiological basis of reduced exercise capacity and guide exercise prescription in this population. Some studies did not focus on reporting adverse events related to exercise testing or failed to mention safety monitoring, which contributed to risk of bias.

Changes in meal-related anxiety predict treatment outcomes in an intensive family-based treatment program for adolescents with anorexia nervosa.

Meal-related anxiety in individuals with eating disorders is associated with reduced caloric intake and persisting eating-disordered behaviors, which may reduce the likelihood of attaining or sustaining remission. The current study is the first to examine changes in meal-related anxiety as a predictor of outcomes in the context of a family-based partial hospitalization program. A sample of 51 adolescents with anorexia nervosa or atypical anorexia rated anxiety before and after all treatment meals using the Subjective Units of Distress Scale (SUDS). Regression analyses suggested that participants experiencing a greater reduction in meal anxiety endorsed fewer eating disordered symptoms on the EDE at the end of treatment. Reductions in meal anxiety did not predict EBW at end of treatment, which could be because family-based treatment (FBT) supports adequate food intake regardless of meal anxiety (i.e., parents ensure food intake). Findings suggest that reductions in meal-related anxiety may be an important predictor of outcomes in family-based interventions, and future research is needed to examine if directly targeting meal anxiety may enhance outcomes.