1.
Preprint
em Inglês
| medRxiv
| ID: ppmedrxiv-21249801
RESUMO
Severe Covid-19 is associated with elevated plasma Factor V (FV) and increased risk of thromboembolism. We report that neutrophils, T regulatory cells (Tregs), and monocytes from patients with severe Covid-19 express FV, and expression correlates with T cell lymphopenia. In vitro full length FV, but not FV activated by thrombin cleavage, suppresses T cell proliferation. Increased and prolonged FV expression by cells of the innate and adaptive immune systems may contribute to lymphopenia in severe Covid-19. Activation by thrombin destroys the immunosuppressive properties of FV. Anticoagulation in Covid-19 patients may have the unintended consequence of suppressing the adaptive immune system.
2.
3.
Phys Rev B Condens Matter
; 46(1): 443-447, 1992 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10002229
4.
Phys Rev B Condens Matter
; 45(17): 10051-10056, 1992 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10000893
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Phys Rev B Condens Matter
; 45(5): 2581-2584, 1992 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10001802
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Phys Rev B Condens Matter
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Artigo
em Inglês
| MEDLINE
| ID: mdl-9996013
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Phys Rev B Condens Matter
; 42(4): 2635-2638, 1990 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9995737
8.