1.
Bioorg Med Chem Lett
; 14(18): 4705-10, 2004 Sep 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15324892
RESUMO
The synthesis of a series of long-chain formoterol analogues in which the terminal ether residue of the beta-phenethyl-amino-substituent has been extended beyond the methyl ether residue present in the parent compound are described. Evaluation of these analogues as beta(2)-adrenoceptor agonists was used to provide an insight into the factors controlling the magnitude and duration of receptor activation.