[The pathogenesis and correction of disorders of the heart rhythm in the early post-resuscitation period]. / K patogenezu i korrektsii narushenii ritma serdtsa v rannem postreanimatsionnom periode.

The frequency and nature of heart rhythm disturbances have been studied in experiments on random-bred male rats who survived 4- and 6-min clinical deaths of acute blood loss. Using correlation analysis it has been shown that the leading pathogenetic arrhythmogenic factors are: catecholamine excess, as well as excess of free fatty acids, lipid peroxidation products, lactate and Ca-ATPase inhibition. The efficacy of preventive (gutimin, inderal, oxipiridin-6, isoptin) and therapeutic (carnozin, creatinphosphate) use of the drugs affecting pathogenetic mechanisms of heart arrhythmias and thus stabilizing bioelectrical heart activity in the early postresuscitation period has been observed.

[Prevention of impairment of myocardium metabolism and function in immobilization stress using previous adaptation to short stress exposures]. / Preduprezhdenie narushenii metabolizma i funktsii serdechnoi myshtsypri immobilizatsionnom stresse s pomoshch'iu predvaritel'noi adaptatsii k korotkim stressornym vozdeistviiam.

A long-term immobilization stress was shown to cause a distinct enzymemia in rats. Simultaneously, activation of lipid peroxidation and a decrease in glycogen content were observed in myocardium; a distinctly increased penetration of aspartate transferase, lactate- and malate dehydrogenases and RNAase into coronary circulation was found in isolated heart of the animals. These impairments of metabolism were accompanied by a depression of the heart contractile function. The impairments in metabolism and in heart functions might be prevented by preadaptation of the animals to multiple short-term immobilization effects, which did not cause any impairments per se.