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1.
Int J Health Plann Manage ; 34(4): 1109-1120, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30875087

RESUMO

INTRODUCTION: The purpose of the article is to present the results of the research aimed at establishing the current situation in the health care system in Slovenia and verifying whether the possibility and support exist for the introduction of a freelance medical specialist. METHODS: We conducted a survey among physicians and health care managers. The sample framework covered the total population of physicians and health care managers in Slovenia; surveys were completed by 318 physicians and 52 health care managers. RESULTS: The results of the quantitative research analysis provided an essential basis for and feedback information about possible areas for improving the current state of the health care system. The conclusions of semistructured interviews also considerably contributed to the elaboration of the freelance medical specialist proposal. CONCLUSION: The findings of the research point out the need for changes in the Slovenian health care system and the support of the research participants in the implementation of the freelance medical specialist proposal. In the participants' opinions, the possibility of introducing freelance medical specialists would change the work organisation, particularly in terms of additional formalised possibilities for practising in the medical profession, which would further contribute to the overall improvement of the health care system.


Assuntos
Atenção à Saúde/organização & administração , Medicina/organização & administração , Adulto , Feminino , Pesquisas sobre Atenção à Saúde , Humanos , Entrevistas como Assunto , Masculino , Médicos/provisão & distribuição , Prática Privada/organização & administração , Prática Privada/estatística & dados numéricos , Melhoria de Qualidade/organização & administração , Eslovênia , Adulto Jovem
2.
AAPS PharmSciTech ; 20(1): 29, 2019 Jan 02.
Artigo em Inglês | MEDLINE | ID: mdl-30603817

RESUMO

Development of drug-loaded wound dressings is often performed without systematic consideration of the changing wound environment that can influence such materials' performance. Among the crucial changes are the wound pH and temperature, which have an immense effect on the drug release. Detailed release studies based on the consideration of these changing properties provide an important aspect of the in vitro performance testing of novel wound dressing materials. A sodium carboxymethyl cellulose-based wound dressing, with the incorporated non-steroidal anti-inflammatory drug diclofenac, was developed and characterised in regard to its physico-chemical, structural and morphological properties. Further, the influence of pH and temperature were studied on the drug release. Finally, the biocompatibility of the wound dressing towards human skin cells was tested. Incorporation of diclofenac did not alter important properties (water retention value, air permeability) of the host material. Changes in the pH and temperature were shown to influence the release performance and have to be accounted for in the evaluation of such dressings. Furthermore, the knowledge about the potential changes of these parameters in the wound bed could be used potentially to predict, and potentially even to control the drug release from the developed wound dressing. The prepared wound dressing was also proven biocompatible towards human skin cells, making it interesting for potential future use in the clinics.


Assuntos
Bandagens , Carboximetilcelulose Sódica/farmacocinética , Diclofenaco/farmacocinética , Liberação Controlada de Fármacos , Cicatrização/efeitos dos fármacos , Anti-Inflamatórios não Esteroides/química , Anti-Inflamatórios não Esteroides/farmacocinética , Carboximetilcelulose Sódica/química , Linhagem Celular , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/fisiologia , Diclofenaco/química , Portadores de Fármacos/química , Portadores de Fármacos/farmacocinética , Avaliação Pré-Clínica de Medicamentos/métodos , Humanos , Concentração de Íons de Hidrogênio , Queratinócitos/efeitos dos fármacos , Queratinócitos/metabolismo , Permeabilidade , Pele/efeitos dos fármacos , Pele/metabolismo , Temperatura , Cicatrização/fisiologia
3.
Acta Clin Croat ; 57(3): 434-442, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31168175

RESUMO

- The aim of the study was to evaluate the efficacy and safety of the new method of platelet-rich plasma activation in the form of platelet gel, used in the treatment of non-healing chronic lower leg ulcers. The study was prospectively randomized, double blind and placebo controlled. We treated 60 patients (42 males and 18 females, mean age 69.43 years, SD 14.74) with chronic lower leg ulcers of different etiologies. Thirty patients were treated with allogeneic platelet gel and 30 with hydrogel. Both groups were comparable for duration of ulcer and its size. Treatment was repeated once a week for three consecutive weeks and then the last examination was scheduled at 6 months of the first platelet gel application. The t-test was used to analyze independent samples. Healing of chronic wounds with platelet gel was statistically significantly more effective compared to the treatment with hydrogel (p<0.05). At 6 months of platelet gel application, the mean wound area in the experimental group decreased to 35.01% (SD 53.69) of the initial wound size. In the control group, the wound area decreased to 89.95% (SD 71.82) of the initial wound size (p=0.001). The circumference of the wounds diminished to 54.62% (SD 39.85) of the initial value in the experimental group, compared to 91.28% (SD 29.32) in the control group (p<0.001). Allogeneic platelet gel prepared by the new method used in this study was found to be a good treatment option for non-healing chronic wounds when other methods are ineffective.


Assuntos
Células Alógenas , Plaquetas , Hidrogéis/administração & dosagem , Úlcera da Perna , Plasma Rico em Plaquetas , Cicatrização/efeitos dos fármacos , Idoso , Doença Crônica , Método Duplo-Cego , Feminino , Géis/administração & dosagem , Humanos , Úlcera da Perna/diagnóstico , Úlcera da Perna/fisiopatologia , Úlcera da Perna/terapia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento
4.
Lasers Med Sci ; 32(4): 887-894, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28342007

RESUMO

Chronic wounds, especially in diabetic patients, represent a challenging health issue. Since standard treatment protocols often do not provide satisfactory results, additional treatment methods-like phototherapy using low-level light therapy-are being investigated. The aim of our study was to evaluate the effect of phototherapy with light-emitting diodes on chronic wound treatment in diabetic and non-diabetic patients. Since a sufficient blood supply is mandatory for wound healing, the evaluation of microcirculation in the healthy skin at a wound's edge was the main outcome measure. Forty non-diabetic patients and 39 diabetics with lower limb chronic wounds who were referred to the University Medical Center Ljubljana between October 2012 and June 2014 were randomized to the treated and control groups. The treated group received phototherapy with LED 2.4 J/cm2 (wavelengths 625, 660, 850 nm) three times a week for 8 weeks, and the control group received phototherapy with broadband 580-900 nm and power density 0.72 J/cm2. Microcirculation was measured using laser Doppler. A significant increase in blood flow was noted in the treated group of diabetic and non-diabetic patients (p = 0.040 and p = 0.033), while there was no difference in the control groups. Additional Falanga wound bed score evaluation showed a significant improvement in both treated groups as compared to the control group. According to our results, phototherapy with LED was shown to be an effective additional treatment method for chronic wounds in diabetic and non-diabetic patients.


Assuntos
Diabetes Mellitus/fisiopatologia , Diabetes Mellitus/radioterapia , Microcirculação/efeitos da radiação , Fototerapia , Cicatrização/efeitos da radiação , Idoso , Doença Crônica , Método Duplo-Cego , Feminino , Hemorreologia/efeitos da radiação , Humanos , Masculino , Pessoa de Meia-Idade , Placebos , Estudos Prospectivos
5.
J Med Case Rep ; 10(1): 108, 2016 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-27142656

RESUMO

BACKGROUND: Calcaneal fractures are relatively rare and difficult to treat. Treatment options vary based on the type of fracture and the surgeon's experiences. In recent years, surgical procedures have increasingly been used due to the better long-term results. We present a case where guided tissue regeneration was performed in a calcaneal fracture that needed primary subtalar arthrodesis. We used the principles of guided tissue regeneration from oral surgery to perform primary subtalar arthrodesis and minimize the risk of non-union. We used a heterologous collagen membrane, which acts as a mechanical barrier and protects the bone graft from the invasion of unwanted cells that could lead to non-union. The collagenous membrane also has osteoconductive properties and is therefore able to increase the osteoblast proliferation rate. CASE PRESENTATION: A 62-year-old Caucasian woman sustained multiple fractures of her lower limbs and spine after a fall from a ladder. Her left calcaneus had a comminuted multifragmental fracture (Sanders type IV) with severe destruction of the cartilage of her subtalar joint and depression of the Böhler's angle. Therefore, we performed primary arthrodesis of her subtalar joint with elevation of the Böhler's angle using a 7.3 mm titanium screw, a heterologous cortico-cancellous collagenated pre-hydrated bone mix, a heterologous cancellous collagenated bone wedge, and a heterologous collagen membrane (Tecnoss®, Italy). The graft was fully incorporated 12 weeks after the procedure and a year and a half later our patient walks without limping. We present a new use of guided tissue regeneration with heterologous materials that can be used to treat extensive bone defects after bone injuries. CONCLUSIONS: We believe that guided tissue regeneration using heterologous materials, including a heterologous collagen membrane that presents a mechanical barrier between soft tissues and bone as well as a stimulative component that enhances bone formation, could be more often used in bone surgery.


Assuntos
Artrodese/métodos , Transplante Ósseo/métodos , Calcâneo/cirurgia , Colágeno , Fraturas Ósseas/cirurgia , Fraturas Cominutivas/cirurgia , Regeneração Tecidual Guiada/métodos , Articulação Talocalcânea/cirurgia , Acidentes por Quedas , Regeneração Óssea , Parafusos Ósseos , Calcâneo/lesões , Feminino , Humanos , Pessoa de Meia-Idade , Articulação Talocalcânea/lesões , Transplante Heterólogo
6.
APMIS ; 124(4): 309-18, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26781044

RESUMO

Staphylococcus aureus is among the most important human pathogens. It is associated with different infections and is a major cause of skin and soft tissue infections (SSTIs). The aim of our study was to compare S. aureus isolates associated with SSTIs with isolates obtained from healthy carriers in the Central Slovenia region in terms of antimicrobial susceptibility, genetic diversity by clonal complex (CC)/sequence type, spa type, and by toxin gene profiling. In total, 274 S. aureus isolates were collected prospectively by culturing wound samples from 461 SSTI patients and nasal samples from 451 healthy carriers. We have demonstrated high heterogeneity in terms of CCs and spa type in both groups of isolates. The main clone among SSTI strains was Panton-Valentine leukocidin gene (pvl) positive CC121, whereas the main clone among carrier strains was CC45 carrying a large range of toxin genes. The main spa type in both groups was t091. Pvl was more frequently present in SSTI strains (31.2% SSTI vs 3.6% carrier strains) and staphylococcal enterotoxin C was more frequently present in carrier strains (1.6% SSTI vs 17.0% carrier strains). We have also demonstrated that methicillin-resistant S. aureus was a rare cause (2.8%) of SSTIs in our region.


Assuntos
Toxinas Bacterianas/genética , Enterotoxinas/genética , Exotoxinas/genética , Genes Bacterianos , Leucocidinas/genética , Staphylococcus aureus/genética , Staphylococcus aureus/patogenicidade , Antibacterianos/farmacologia , Doenças Assintomáticas , Toxinas Bacterianas/biossíntese , Farmacorresistência Bacteriana Múltipla/genética , Enterotoxinas/biossíntese , Exotoxinas/biossíntese , Expressão Gênica , Variação Genética , Genótipo , Humanos , Leucocidinas/biossíntese , Testes de Sensibilidade Microbiana , Tipagem de Sequências Multilocus , Estudos Prospectivos , Pele/microbiologia , Eslovênia , Infecções dos Tecidos Moles/tratamento farmacológico , Infecções dos Tecidos Moles/microbiologia , Infecções dos Tecidos Moles/patologia , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/microbiologia , Infecções Estafilocócicas/patologia , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus aureus/isolamento & purificação
7.
Wien Klin Wochenschr ; 127 Suppl 5: S187-98, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26404739

RESUMO

The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.


Assuntos
Bandagens , Lacerações/terapia , Tratamento de Ferimentos com Pressão Negativa/métodos , Transplante de Pele/métodos , Pele Artificial , Pele/lesões , Terapia Combinada/métodos , Humanos , Lacerações/diagnóstico
8.
Int J Dermatol ; 54(7): 740-51, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25808157

RESUMO

Herbs have been integral to both traditional and non-traditional forms of medicine dating back at least 5000 years. The enduring popularity of herbal medicines may be explained by the perception that herbs cause minimal unwanted side effects. More recently, scientists increasingly rely on modern scientific methods and evidence-based medicine to prove efficacy of herbal medicines and focus on better understanding of mechanisms of their action. However, information concerning quantitative human health benefits of herbal medicines is still rare or dispersed, limiting their proper valuation. Preparations from traditional medicinal plants are often used for wound healing purposes covering a broad area of different skin-related diseases. Herbal medicines in wound management involve disinfection, debridement, and provision of a suitable environment for aiding the natural course of healing. Here we report on 22 plants used as wound healing agents in traditional medicine around the world. The aim of this review is therefore to review herbal medicines, which pose great potential for effective treatment of minor wounds.


Assuntos
Preparações de Plantas/farmacologia , Cicatrização/efeitos dos fármacos , Desbridamento , Desinfecção , Humanos , Cicatrização/fisiologia
9.
Coll Antropol ; 38(3): 865-70, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25420367

RESUMO

The aim of this study is to analyze the morphologic and functional change of human bone defect after its grafting with mixture of platelet gel and autologous cancellous bone. For one year, we have prospectively studied nine consecutive pa- tients, aged 25-73 y, with pseudoarthrosis of long bones, after unsuccessful initial surgeries. We have harvested can- cellous bone from patients' iliac crests and mixed with the ABO compatible allogeneic platelet rich plasma (PRP) gel. That mixture has been inserted in the bone defect, and surgically fixated. Radiologically, the defects achieved the bone morphology (the appearance of hazy callus) between 6th and 24th week. The time of functional recovery was varied, be- tween 12 and 40 weeks for partial weight bearing, and between 16 and 48 weeks for free limb mobility and full function of the limb. The overall healing of bone defect was 16 to 36 weeks. Two patients had complications of poor graft ingrowth and one with a reversible postsurgical nerve paresis. On the X-ray scans, solid and fast restoration of bone structure was notable, with excellent bone ingrowth, suitable for full weight bearing. The allogeneic platelet gel had no adverse effects. This method can be used for treating of long bone defects, because of its strong influence on restoration of normal bone morphology. Further investigation is required to establish efficiency relative to other methods.


Assuntos
Transplante Ósseo/métodos , Plasma Rico em Plaquetas/fisiologia , Adulto , Idoso , Géis , Humanos , Pessoa de Meia-Idade , Estudos Prospectivos , Recuperação de Função Fisiológica , Transplante Homólogo
10.
J Med Case Rep ; 8: 322, 2014 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-25266945

RESUMO

INTRODUCTION: Total extrusion and loss of the talus is a rare injury with a wide choice of appropriate treatment, but rarely resulting in a fully functional recovery. We report on an uncommon case, both for the severity of the injury and for the uncommon treatment due to the patient's rejection of secondary surgery. CASE PRESENTATION: We treated a 16-year-old Caucasian man with the most extreme variant of a totally extruded and lost talus, accompanied with complex injury of the soft tissues of the ankle and foot. The treatment included urgent microvascular foot reimplantation, microvascular muscle free flap transfer, and temporary fixation. This kind of injury should typically be treated by tibiocalcaneal arthrodesis. However, this was not performed, as after the successful early stages of the treatment he strongly objected to another surgery due to his fully functional status and the successful therapeutic results of our early treatment. CONCLUSIONS: The injury described in this case study would ordinarily be treated by amputation, but due to the well-executed treatment in the early stages after the injury, the outcome was satisfying. Surprisingly and against our expectations, the late results of the treatment were successful even without arthrodesis. He is now 37 years old and has a functional foot 21 years after the injury.


Assuntos
Amputação Traumática/cirurgia , Fraturas do Tornozelo/cirurgia , Fixação Interna de Fraturas/métodos , Retalhos de Tecido Biológico/transplante , Procedimentos de Cirurgia Plástica/métodos , Reimplante/métodos , Tálus/lesões , Adolescente , Artrodese , Fraturas Expostas/cirurgia , Humanos , Masculino , Ossos do Metatarso/lesões , Ossos do Metatarso/cirurgia , Falanges dos Dedos do Pé/lesões , Falanges dos Dedos do Pé/cirurgia
11.
Coll Antropol ; 38(2): 505-9, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25144980

RESUMO

The aim of this work is to radiologicaly estimate the width, height and depth of bodies of thoracic and lumbal vertebras. Charts of one hundred and seventeen patients with implanted internal fixateur on the thoracic and lumbal spine, between 01.01.2008. and 31.3.2010. at the Department of Orthopedics and Traumatology - Clinical Centre Sarajevo, were retrieved, and only 14 patients, with totally 46 vetrtebras have meet including criteria (clearly visible measured structures on X-ray and CT scans, and data about implants dimensions). Digitalized anteroposterior and laterolateral X-ray, and transversal and sagital CT scans were basic inputs for measurement of height, width and depth of the vertebral body--CH, CW, CD. The correction of enlargement on X-ray pictures was performed according to known dimensions of implants and the length scale on CT scans. Enlargement of those parameters, from T1 to L5 spine level was from 60 to 100%, except the stagnation in the mid-thoracic region, and decreasing of corporal depth on the L5 vertebra (CD/L5), in comparison to the fourth vertebra (CD/L4). The clinical importance of this work is in estimation and comparison of dimensions of vertebral bodies measured on X-ray and CT scans, as the basic inputs during surgical procedures of vertebroplasty and anterior spondilodesis.


Assuntos
Vértebras Lombares/diagnóstico por imagem , Vértebras Torácicas/diagnóstico por imagem , Humanos , Radiografia
12.
Coll Antropol ; 37(1): 189-94, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-23697272

RESUMO

The goal of this study was to evaluate associations between the meteorological conditions and the number of emergency cases for five distinctive causes of dispatch groups reported to SOS dispatch centre in Uppsala, Sweden. Center's responsibility include alerting to 17 ambulances in whole Uppsala County, area of 8,209 km2 with around 320,000 inhabitants representing the target patient group. Source of the medical data for this study is the database of dispatch data for the year of 2009, while the metrological data have been provided from Uppsala University Department of Earth Sciences yearly weather report. Medical and meteorological data were summoned into the unified data space where each point represents a day with its weather parameters and dispatch cause group cardinality. DBSCAN data mining algorithm was implemented to five distinctive groups of dispatch causes after the data spaces have gone through the variance adjustment and the principal component analyses. As the result, several point clusters were discovered in each of the examined data spaces indicating the distinctive conditions regarding the weather and daily cardinality of the dispatch cause, as well as the associations between these two. Most interesting finding is that specific type of winter weather formed a cluster only around the days with the high count of breathing difficulties, while one of the summer weather clusters made similar association with the days with low number of cases. Findings were confirmed by confidence level estimation based on signal to noise ratio for the observed data points.


Assuntos
Serviço Hospitalar de Emergência/organização & administração , Tempo (Meteorologia) , Dor Abdominal/diagnóstico , Algoritmos , Dor no Peito/diagnóstico , Análise por Conglomerados , Mineração de Dados , Bases de Dados Factuais , Tontura , Cefaleia/diagnóstico , Humanos , Pneumopatias/diagnóstico , Atenção Primária à Saúde/organização & administração , Estações do Ano , Acidente Vascular Cerebral/diagnóstico , Suécia
13.
Acta Med Croatica ; 66 Suppl 1: 65-70, 2012 Oct.
Artigo em Servo-Croata (Latino) | MEDLINE | ID: mdl-23193824

RESUMO

Chronic and acute infected wounds can pose a major clinical problem because of associated complications and slow healing. In addition to classic preparations for wound treatment, an array of modern dressings for chronic wound care are currently available on the market. These dressings are intended for the wounds due to intralesional physiological, pathophysiological and pathological causes and which failed to heal as expected upon the use of standard procedures. Classic materials such as gauze and bandage are now considered obsolete and of just historical relevance because modern materials employed in wound treatment, such as moisture, warmth and appropriate pH are known to ensure optimal conditions for wound healing. Modern wound dressings absorb wound discharge, reduce bacterial contamination, while protecting wound surrounding from secondary infection and preventing transfer of infection from the surrounding area onto the wound surface. The use of modern wound dressings is only justified when the cause of wound development has been established or chronic wound due to the underlying disease has been diagnosed. Wound dressing is chosen according to wound characteristics and by experience. We believe that the main advantages of modern wound dressings versus classic materials include more efficient wound cleaning, simpler placement of the dressing, reduced pain to touch, decreased sticking to the wound surface, and increased capacity of absorbing wound exudate. Modern wound dressings accelerate the formation of granulation tissue, reduce the length of possible hospital stay and facilitate personnel work. Thus, the overall cost of treatment is reduced, although the price of modern wound dressings is higher than that of classic materials. All types of modern wound dressings, their characteristics and indications for use are described.


Assuntos
Curativos Oclusivos , Ferimentos e Lesões/terapia , Doença Crônica , Humanos , Cicatrização
14.
Coll Antropol ; 36(4): 1313-7, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23390827

RESUMO

The aim of this work is to measure clinically important dimensions of thoracic and lumbal vertebras. Charts of one-hundred and seventeen patients with implanted internal fixateur on the thoracic and lumbal spine between 01.01. 2008. and 31.3.2010. at the Department for Orthopedics and Traumatology, of the Sarajevo Clinical center were retrieved, and only 14 patients, with 46 vetrtebras and 89 pedicles have had complete documentation (clearly visible measured structures on X-ray and CT scans). Digitalized antero-posterior and latero-lateral X-ray, and transversal and sagital CT scans were basic inputs for measurement of height and width of the pedicle--PH, PW, axial and vertical cortico-cortical transpedicular distances--AL, VL, and interpedicular distance--IP. The correction of enlargement on X-ray pictures was performed according to known dimensions of implants and length scale on CT scans. Enlargement of those parameters, from T1 to L5 level was from 50 to 150%. This increasing was not always linear, sometimes there was even decreasing. For instance, the IP on second and third thoracic vertebra was shorter compared to the first thoracic vertebra. Pedicles from the third to the eighth thoracic vertebra were narrower compared to the second thoracic vertebra. The importance of this work is in to analyze the mentioned dimensions by methods available to the clinician. Every other in vivo measurement is impossible because of the excessive surgical approach, while preoperative CT scanning with a great number of slices per one millimeter for this purpose is not ethical.


Assuntos
Fixadores Internos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/cirurgia , Fusão Vertebral , Vértebras Torácicas/diagnóstico por imagem , Vértebras Torácicas/cirurgia , Humanos , Doenças da Coluna Vertebral/diagnóstico por imagem , Doenças da Coluna Vertebral/cirurgia , Tomografia Computadorizada por Raios X
15.
Med Arh ; 65(3): 149-52, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21776875

RESUMO

UNLABELLED: The adolescent idiopathic scoliosis - AIS over 40 degrees measured by Cobb, are treated by surgery. Most frequently are used corrective spondylodesis by Harrington (with hooks), by Luqe (with wires), anterior spondylodesis (with transcorporal screws). In last two decades, the posterior corrective spondylodesis by transpedicular screws is popularized. Aim of this work is to present advantages and disadvantages of posterior corrective spondylodesis of scoliosis. METHODOLOGY: Twenty-three patients have been included in this study, average age of 15 y. (10-32), and mostly female gender. The dynamic and quality of postoperative flow after posterior corrective spondylodesis have been analyzed at the AIS patients on the Dept. of orthopedics and traumatology, Clinical centre University of Sarajevo during last three years. RESULTS: The length of postoperative hospitalization in the analyzed group was 7 days, compared with results achieved by other methods. Faster recovery, returning to life activities, final esthetic and functional result were superior, and there was no need for revision surgery. CONCLUSION: of this work is that posterior corrective spondylodesis by transpedicular screws at the AIS patients is method of choice, if all requirements of correct performing of that method are met.


Assuntos
Fusão Vertebral/métodos , Adolescente , Adulto , Criança , Feminino , Humanos , Fixadores Internos , Masculino , Radiografia , Escoliose/diagnóstico por imagem , Escoliose/cirurgia , Fusão Vertebral/instrumentação , Coluna Vertebral/diagnóstico por imagem , Adulto Jovem
16.
Coll Antropol ; 34(3): 931-5, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20977085

RESUMO

The implantation of a bipolar partial hip endoprosthesis is a treatment of choice for displaced medial femoral neck fracture. We present an experimental study which asses and compare biomechanical and clinical status through period before and after hip fracture and implantation of bipolar partial hip endoprosthesis. This study encompassed 75 patients who suffered from an acute medial femoral neck fracture and were treated with the implantation of a bipolar partial hip endoprosthesis. Their biomechanical status (stress distribution on the hip joint weight bearing area) and clinical status (Harris Hip Score) were estimated for the time prior to the injury and assessed at the follow-up examination that was, on average, carried out 40 months after the operation. Despite ageing, the observed Harris Hip Score at the follow-up examination was higher than that estimated prior to the injury (77.9 > 69.6; p = 0.006). Similarly, the hip stress distribution was reduced (2.7 MPa < 2.3 MPa; p = 0.001). While this reduction can be attributed to a loss of weight due to late ageing, the principal improvement came from the operative treatment and corresponding restoration of the biomechanical properties of the hip joint. The implantation of a bipolar partial hip endoprosthesis for patients with displaced medial femoral neck fractures improves the biomechanical and clinical features of the hip, what should have on mind during making decision about treatment.


Assuntos
Artroplastia de Quadril , Fraturas do Colo Femoral/fisiopatologia , Fraturas do Colo Femoral/cirurgia , Articulação do Quadril/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Fenômenos Biomecânicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
17.
Clin Transplant ; 23(6): 968-74, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-19712088

RESUMO

Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), is a rare complication in patients with end-stage renal disease as well as in patients after renal transplantation. It should be suspected in patients with typical painful violaceous skin lesions on the extremities or on the trunk. Active multidisciplinary management approach, with intensive local wound care, is vital in these patients. Controlling parathyroid hormone, hyperbaric oxygenation, sodium thiosulphate, bisphosphonates, cinacalcet and skin grafting could be effective. In our report, we describe a case of CUA in a 43-year-old patient two years after kidney transplantation. Despite intensive standard treatment, his wounds progressed; therefore, we decided to use iloprost, in combination with hyperbaric oxygenation. The clean wounds were then covered with cultivated autologous skin cells to enhance wound epithelialization. Seven months after finishing iloprost and hyperbaric oxygen treatment and the first application of skin substitute, the wounds healed completely and remained healed during the four-yr follow-up period. We conclude that in patients with severe CUA-induced wounds, the combined treatment with iloprost, hyperbaric oxygen and autologous cultured fibrin-based skin substitutes can be effective. A combination of different treatment modalities is vital in patients with CUA.


Assuntos
Calciofilaxia/terapia , Fibrina/farmacologia , Oxigenoterapia Hiperbárica/métodos , Iloprosta/uso terapêutico , Transplante de Rim/efeitos adversos , Pele Artificial , Pele/citologia , Adulto , Calciofilaxia/etiologia , Transplante de Células/métodos , Células Cultivadas , Humanos , Masculino , Índice de Gravidade de Doença , Vasodilatadores/uso terapêutico
18.
Med Arh ; 63(4): 234-7, 2009.
Artigo em Bosnio | MEDLINE | ID: mdl-20088184

RESUMO

A pathologic fracture is every fracture caused by minimal trauma of the bone weakened by some process (osteoporosis, tumor, etc.). Most common pathological spine fractures are compressive fractures of thoracolumbal vertebras in geriatric patients. Considering the fact that geriatric population often have numerous comorbidities, weakened bone quality, and that instrumented spondylodeses have increased surgical risk, minimally invasive procedures are treatment of the choice for described fractures. Principle of the minimally invasive treatment of compressive spine fractures is to inject bone cement percutaneously into the collapsed vertebral body through transpediculary placed cannulas, under the X-ray control. After this ambulatory procedure, patient has prompt lack of pain, full mobility; risks of surgery are lower then one promil. In this article we describe first Bosnian experiences after those surgeries (vertebroplasty, kyphoplasty, percutaneus biopsy of spine metastasis) performed at the Department for Orthopedics and Traumatology of Clinical Centre University of Sarajevo.


Assuntos
Fraturas por Compressão/cirurgia , Fraturas Espontâneas/cirurgia , Fraturas da Coluna Vertebral/cirurgia , Vertebroplastia , Idoso , Feminino , Humanos , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Minimamente Invasivos
19.
Coll Antropol ; 32(3): 875-9, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18982764

RESUMO

Aim of this study was to estimate how knee osteoarthritis (OA) affects the shape of femoral condyles by comparing the radiuses of condylar curves between healthy and OA knees. Seventeen female and five male patients with established diagnosis of knee OA were included in the study. Radiuses of medial and lateral condylar curves were calculated from the side view knee X-ray by original mathematical equation and compared to referent values of healthy knees, after adjusting to body height. The average radiuses of condylar curves were between 52.6 +/- 6.2 and 17.6 +/- 3.5 mm medially, and between 43.3 +/- 8.4 and 15.4 +/- 3.7 mm laterally for 0 degrees and 90 degrees femoral flexion contact points, respectively The OA knees had longer curve radiuses medially and laterally at 0 degrees, 10 degrees, and 20 degrees femoral flexion contact points in comparison to the healthy sample (P < 0.001; t-test). Our results suggest that the shape of the femoral condyles in OA knees is changed. It should be aware not only in researching of OA etiology, but also in designing of knee endoprostheses, in a manner to achieve better individual sizing.


Assuntos
Fêmur/patologia , Osteoartrite do Joelho/patologia , Idoso , Feminino , Fêmur/diagnóstico por imagem , Humanos , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/patologia , Articulação do Joelho/fisiopatologia , Masculino , Pessoa de Meia-Idade , Osteoartrite do Joelho/diagnóstico por imagem , Radiografia , Amplitude de Movimento Articular
20.
Acta Med Croatica ; 62(3): 257-62, 2008 Jul.
Artigo em Servo-Croata (Latino) | MEDLINE | ID: mdl-18843844

RESUMO

AIM: The percentage of elderly people increases in societies today and so does the number of specific conditions, illnesses and injuries, with hip fracture as the most important one. The aim of the study was to point to hip fracture as a medical and social problem by objectively quantifying functional abilities of geriatric patients after hip fracture. PATIENTS AND METHODS: The study included 414 (63 male and 351 female) with femoral neck fracture and hip endoprosthesis implanted at University Department of Traumatology in Ljubljana during the 1988-2004 period. Data on sex distribution, concomitant diseases, complications, estimation of functionality before injury, and dynamic and final level of functional recovery were collected. RESULTS: The patient mean age was 77 +/- 7.3 (range 28-96) years. Excellent mobility before injury, according to personal report, was recorded in 322 (77.78%), good mobility in 78 (18.84%) and poor mobility in only 14 (3.38%) patients. The mean dynamics of functional recovery was as follows: independent sitting at 2 days, standing at 3.6 days, and walking at 7 days of the surgery. At the end of rehabilitation, an average patient felt periodic pain that did not affect his/her activities, could walk without problems at least one kilometer, limped to a certain degree, used a cane, could climb stairs holding a handrail, sat in the chair for a long time, put on shoes and socks with minor difficulties, used public transportation and had no significant deformity of the hip. With that level of functionality, our patients were independent in daily activities, able to stay socially integrated, and other people's help was reduced to the minimum. DISCUSSION: The patient's functionality before injury, the duration and quality of rehabilitation after surgery, and the patient's motivation and cooperation during rehabilitation are the key factors of patient recovery to the pre-injury state. In spite of numerous concomitant diseases, reduced psychophysical abilities of the elderly and medical difficulties in the management of these injuries, such treatment of hip fractures is necessary and human for patients and time-consuming for medical staff, yet being the most profitable option for the society. Hip fracture and consequential disablement cause a double problem. On the one hand, it entails dependence on other person, family or social institution, or society in general, and on the other hand there is mental frustration, especially if he/she is psychically instable. Quite frequently, disabled persons have psychical traumas that have unfavorable impact on their families. It is additionally complicated in societies that tend to stigmatization of disabled persons. Therefore, it is very important how the society will behave toward disabled elderly who are generally more vulnerable.


Assuntos
Fraturas do Quadril/cirurgia , Atividades Cotidianas , Adulto , Idoso , Idoso de 80 Anos ou mais , Artroplastia de Quadril , Feminino , Fraturas do Colo Femoral/cirurgia , Prótese de Quadril , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
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