[Rosette-formation phenomenon in autocultures of human venous blood leukocytes]. / Fenomen rozetkoobrazovaniia v autokul'ture leikotsitov venoznoi krovi cheloveka

A method of human venous blood leukocyte culture permits to model immunological processes of an intact organism. Aggregation with lymphoid elements of the central target cell serves as a morphological expression of complicated cell interrelations under conditions of their extracorporeal cultivation. It may be that such interaction of mononuclears in the culture was caused by a special humoral factor generated by lymphocytes. The occurrence of the "rosette" phenomenon in the autoculture permits to suppose that there is a possibility of obtaining an antigenic information by lymphoid elements in the intact organism. The existence of a correlation between the processes of formation of intercellular associations in vitro and the severity of the disease in persons with allergy confirms this supposition.