RESUMO
A method for spectroscopic determination of ceftriaxone in saliva of healthy subjects and patients with upper respiratory tract infections was developed. The concentration range is 1-50 mcg/ml. The method is express and simple, and can be used to determine ceftriaxone in clinical tests and pharmacokinetic studies. Possible determination of ceftriaxone in aqueous solutions was demonstrated which is useful in analysis of drugs.
Assuntos
Ceftriaxona/análise , Saliva/química , Ceftriaxona/farmacocinética , Humanos , Infecções Respiratórias/tratamento farmacológico , Espectrofotometria UltravioletaRESUMO
The analysis of the literature data for the last 10 years showed that microbiological, spectroscopic, chromatographic and electrochemical methods were most often used in quantitative determination of antibiotics in biological samples and drugs. Beta-lactams, aminoglycosides, tetracyclines, fluoroquinolones and other antibiotics were widely investigated. The characteristics of different methods of the antibiotic determination were discussed.
