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1.
J Vet Diagn Invest ; 36(3): 362-367, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38520057

RESUMO

Fish maintained in managed care may have longer lifespans as a result of advances in veterinary medicine and husbandry and reduced risk of predation. Neoplasia is of increasing interest in managed aquarium populations. However, few studies have systematically evaluated neoplasia in managed fish populations. Our objective in this retrospective study was to review and describe neoplasia diagnosed in fish at a large public display aquarium between 2005 and 2021. Any fish diagnosed with neoplasia on either antemortem or postmortem evaluation during the study period was included, and all medical records, biopsy, and autopsy reports were reviewed. Sixty-two fish met the inclusion criteria; 37 species were included in the study population, most of which were tropical freshwater fish (n = 34 fish). Thirty-two types of neoplasia were identified. Ten fish had benign neoplasms, and 53 fish had malignant neoplasms. The most common neoplasms were of epithelial and neuroectodermal origin. The most common site of tumor origin was the skin. Our data suggest that mesenchymal neoplasms may be more common in cold saltwater fish than in tropical freshwater and saltwater fish. Malignant neoplasms were most commonly diagnosed in the study population and should be a top differential when neoplasms are identified in fish managed under human care. Our study contributes to the overall knowledge of the health of aquarium fish and may aid clinicians in characterizing neoplasia that may be present in fish under human care.


Assuntos
Doenças dos Peixes , Peixes , Neoplasias , Animais , Estudos Retrospectivos , Neoplasias/veterinária , Neoplasias/epidemiologia , Neoplasias/patologia , Doenças dos Peixes/patologia , Doenças dos Peixes/epidemiologia
2.
Front Microbiol ; 14: 1302586, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38125577

RESUMO

The emergence of ophidiomycosis (or snake fungal disease) in snakes has prompted increased awareness of the potential effects of fungal infections on wild reptile populations. Yet, aside from Ophidiomyces ophidiicola, little is known about other mycoses affecting wild reptiles. The closely related genus Paranannizziopsis has been associated with dermatomycosis in snakes and tuataras in captive collections, and P. australasiensis was recently identified as the cause of skin infections in non-native wild panther chameleons (Furcifer pardalis) in Florida, USA. Here we describe five cases of Paranannizziopsis spp. associated with skin lesions in wild snakes in North America and one additional case from a captive snake from Connecticut, USA. In addition to demonstrating that wild Nearctic snakes can serve as a host for these fungi, we also provide evidence that the genus Paranannizziopsis is widespread in wild snakes, with cases being identified in Louisiana (USA), Minnesota (USA), Virginia (USA), and British Columbia (Canada). Phylogenetic analyses conducted on multiple loci of the fungal strains we isolated identified P. australasiensis in Louisiana and Virginia; the remaining strains from Minnesota and British Columbia did not cluster with any of the described species of Paranannizziopsis, although the strains from British Columbia appear to represent a single lineage. Finally, we designed a pan-Paranannizziopsis real-time PCR assay targeting the internal transcribed spacer region 2. This assay successfully detected DNA of all described species of Paranannizziopsis and the two potentially novel taxa isolated in this study and did not cross-react with closely related fungi or other fungi commonly found on the skin of snakes. The assay was 100% sensitive and specific when screening clinical (skin tissue or skin swab) samples, although full determination of the assay's performance will require additional follow up due to the small number of clinical samples (n = 14 from 11 snakes) available for testing in our study. Nonetheless, the PCR assay can provide an important tool in further investigating the prevalence, distribution, and host range of Paranannizziopsis spp. and facilitate more rapid diagnosis of Paranannizziopsis spp. infections that are otherwise difficult to differentiate from other dermatomycoses.

3.
J Fish Dis ; 45(5): 729-742, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35235682

RESUMO

Atlantic Salmon (Salmo salar) and Chinook Salmon (Oncorhynchus tshawytscha) develop a severe liver disease called net-pen liver disease (NPLD), which is characterized by hepatic lesions that include megalocytosis and loss of gross liver structure. Based on studies where salmonids have been exposed to microcystin (MC) via intraperitoneal injection, NPLD is believed to be caused by MC exposure, a hepatotoxin produced by cyanobacteria. Despite the link between MC and NPLD, it remains uncertain if environmentally relevant MC exposure is responsible for NPLD. To determine if we could produce histopathology consistent with NPLD, we compared the response of Atlantic and Chinook Salmon sub-lethal MC exposure. Salmon were orally gavaged with saline or MC containing algal paste and sampled over 2 weeks post-exposure. Liver lesions appeared by 6 h but were resolved 2-weeks post-exposure; histopathological changes observed in other tissues were not as widespread, nor was their severity as great as those in the liver. There was no evidence for NPLD due to the absence of hepatic megalocytosis. These results indicate that the development of NPLD is not due to acute MC exposure but may be associated with higher MC concentration occurring in food, long-term exposure through drinking of contaminated seawater and/or interactions with other marine toxins.


Assuntos
Doenças dos Peixes , Salmo salar , Animais , Doenças dos Peixes/induzido quimicamente , Doenças dos Peixes/patologia , Microcistinas
4.
Sci Rep ; 10(1): 4731, 2020 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-32152376

RESUMO

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

5.
Dis Aquat Organ ; 132(3): 221-227, 2019 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-31188138

RESUMO

An adult male snapping turtle with marked palpebral edema and multifocal skin ulceration was found alive in a marsh in southern Ontario in summer 2017. The turtle was transported to a rehabilitation facility and died 4 d after arrival. The carcass was submitted to the Canadian Wildlife Health Cooperative for post-mortem examination. Gross lesions included ulcerative conjunctivitis, necrotizing stomatitis, and splenomegaly. Microscopically, this corresponded to multisystemic fibrinonecrotizing vasculitis and severe fibrinous splenic necrosis. Liver tissue tested positive for frog virus 3-like ranavirus and negative for herpesvirus via polymerase chain reaction. The gross and microscopic lesions were consistent with previous reports of ranavirus infection in turtles and were severe enough to have been the cause of death in this case. This is the first report of morbidity and mortality in a common snapping turtle with a ranavirus infection, and the first reported case of ranavirus infection in a reptile in Canada. Ranaviruses are considered to be an emerging infectious disease in chelonians as they are increasing in distribution, prevalence, and host range.


Assuntos
Ranavirus , Animais , Animais Selvagens , Canadá , Masculino , Répteis
6.
Sci Rep ; 9(1): 3297, 2019 03 13.
Artigo em Inglês | MEDLINE | ID: mdl-30867461

RESUMO

Piscine orthoreovirus (PRV) is ubiquitous in farmed Atlantic salmon and sometimes associated with disease - most notably, Heart and Skeletal Muscle Inflammation (HSMI). However, PRV is also widespread in non-diseased fish, particularly in Pacific Canada, where few cases of severe heart inflammation have been documented. To better understand the mechanisms behind PRV-associated disease, this study investigated the infection dynamics of PRV from Pacific Canada and the potential for experimental passage of putatively associated heart inflammation in Pacific-adapted Mowi-McConnell Atlantic salmon. Regardless of the PRV source (fish with or without HSMI-like heart inflammation), infections led to high-load viremia that induced only minor focal heart inflammation without significant transcriptional induction of inflammatory cytokines. Repeated screening of PRV dsRNA/ssRNA along with histopathology and gene expression analysis of host blood and heart tissues identified three distinct phases of infection: (1) early systemic dissemination and replication without host recognition; (2) peak replication, erythrocyte inclusion body formation and load-dependent host recognition; (3) long-term, high-load viral persistence with limited replication or host recognition sometimes accompanied by minor heart inflammation. These findings contrast previous challenge trials with PRV from Norway that induced severe heart inflammation and indicate that strain and/or host specific factors are necessary to initiate PRV-associated disease.


Assuntos
Doenças dos Peixes/virologia , Orthoreovirus/patogenicidade , Infecções por Reoviridae/virologia , Salmo salar/virologia , Virulência/fisiologia , Animais , Aquicultura , Canadá , Eritrócitos/virologia , Coração/virologia , Inflamação/virologia , Músculo Esquelético/virologia , Noruega , Carga Viral/métodos
7.
PLoS One ; 11(1): e0146229, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26730591

RESUMO

Heart and skeletal muscle inflammation (HSMI) is a significant and often fatal disease of cultured Atlantic salmon in Norway. The consistent presence of Piscine orthoreovirus (PRV) in HSMI diseased fish along with the correlation of viral load and antigen with development of lesions has supported the supposition that PRV is the etiologic agent of this condition; yet the absence of an in vitro culture system to demonstrate disease causation and the widespread prevalence of this virus in the absence of disease continues to obfuscate the etiological role of PRV with regard to HSMI. In this study, we explore the infectivity and disease causing potential of PRV from western North America-a region now considered endemic for PRV but without manifestation of HSMI-in challenge experiments modeled upon previous reports associating PRV with HSMI. We identified that western North American PRV is highly infective by intraperitoneal injection in Atlantic salmon as well as through cohabitation of both Atlantic and Sockeye salmon. High prevalence of viral RNA in peripheral blood of infected fish persisted for as long as 59 weeks post-challenge. Nevertheless, no microscopic lesions, disease, or mortality could be attributed to the presence of PRV, and only a minor transcriptional induction of the antiviral Mx gene occurred in blood and kidney samples during log-linear replication of viral RNA. Comparative analysis of the S1 segment of PRV identified high similarity between this North American sequence and previous sequences associated with HSMI, suggesting that factors such as viral co-infection, alternate PRV strains, host condition, or specific environmental circumstances may be required to cause this disease.


Assuntos
Doenças dos Peixes/virologia , Orthoreovirus/fisiologia , Infecções por Reoviridae/virologia , Salmo salar/virologia , Sequência de Aminoácidos , Animais , Cardiomiopatias/virologia , Doenças Endêmicas , Doenças dos Peixes/epidemiologia , Doenças dos Peixes/transmissão , Interações Hospedeiro-Patógeno , Dados de Sequência Molecular , Músculo Esquelético/patologia , Músculo Esquelético/virologia , Miosite/virologia , América do Norte/epidemiologia , Orthoreovirus/classificação , Orthoreovirus/genética , Filogenia , Prevalência , RNA Viral/sangue , RNA Viral/genética , RNA Viral/metabolismo , Infecções por Reoviridae/epidemiologia , Infecções por Reoviridae/transmissão , Salmo salar/sangue , Homologia de Sequência de Aminoácidos , Fatores de Tempo
8.
Can Vet J ; 55(5): 475-9, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24790235

RESUMO

A 7-year-old, intact male, pet dwarf rabbit (Oryctolagus cuniculus) was presented for a ventral abdominal subcutaneous mass. Histolopathology of the resected mass was suggestive of a mammary adenocarcinoma. Six months later, the rabbit died from severe dyspnea. Necropsy showed recurrence of the original mass with hepatic and pulmonary metastasis of the anaplastic adenocarcinoma, suspected to be of mammary origin.


Adénocarcinome anaplasique métastatique, suspecté d'origine mammaire, chez un lapin mâle intact(Oryctolagus cuniculus) . Un lapin nain de compagnie mâle intact âgé de 7 ans (Oryctolagus cuniculus) a été présenté pour une masse sous-cutanée abdominale ventrale. L'histopathologie de la masse reséquée était en faveur d'un adénocarcinome mammaire. Six mois plus tard, le lapin est mort de dyspnée grave. La nécropsie a montré la récurrence de la masse originale avec des métastases hépatiques et pulmonaires de l'adénocarcinome anaplasique, suspecté d'origine mammaire.(Traduit par Isabelle Vallières).


Assuntos
Adenocarcinoma/veterinária , Neoplasias Hepáticas/veterinária , Neoplasias Pulmonares/veterinária , Glândulas Mamárias Animais/patologia , Neoplasias Mamárias Animais/diagnóstico , Coelhos , Adenocarcinoma/classificação , Animais , Feminino , Neoplasias Hepáticas/secundário , Neoplasias Pulmonares/secundário , Masculino , Neoplasias Mamárias Animais/patologia
9.
Can Vet J ; 54(1): 55-60, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23814302

RESUMO

A 7-month-old Australian kelpie dog and a 14-month-old Labrador retriever dog were diagnosed with an uncommon form of cerebellar abiotrophy called cerebellar granuloprival degeneration. This was characterized by a loss of the granular neurons with relative sparing of the Purkinje neurons.


Dégénérescence cérébelleuse granuloprive chez un chien Kelpie australien et un chien Labrador retriever. Un chien Kelpie australien âgé de 7 mois et un chien Labrador retriever âgé de 14 mois ont été diagnostiqués avec une forme rare d'abiotrophie cérébelleuse appelée dégénérescence cérébelleuse granuloprive. Elle a été caractérisée par la perte de neurones granulaires en épargnant en grande partie les neurones de Purkinje.(Traduit par Isabelle Vallières).


Assuntos
Doenças do Cão/diagnóstico , Degenerações Espinocerebelares/veterinária , Animais , Cruzamento , Doenças do Cão/patologia , Cães , Evolução Fatal , Feminino , Imuno-Histoquímica/veterinária , Exame Neurológico/veterinária , Células de Purkinje/patologia , Degenerações Espinocerebelares/diagnóstico , Degenerações Espinocerebelares/patologia , Tremor/etiologia , Tremor/veterinária
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