Complex analysis of multiple single nucleotide polymorphisms as putative risk factors of tooth agenesis in the Hungarian population.

OBJECTIVES: The role was studied of multiple single nucleotide polymorphisms in tooth agenesis in the Hungarian population using a complex approach. METHODS: Eight SNPs, PAX9 -912 C/T, PAX9 -1031 A/G, MSX1 3755 A/G, FGFR1 T/C rs881301, IRF6 T/C rs764093, AXIN2-8150 A/G, AXIN2-8434 A/G and AXIN2-30224 C/T, were studied in 192 hypodontia and 17 oligodontia cases and in 260 healthy volunteers. Case-control analysis was performed to test both allelic and genotypic associations as well as associations at the level of haplotypes. Multivariate exploratory Bayesian network-based multi-level analysis of relevance (BN-BMLA) as well as logistic regression analysis were performed. RESULTS: Conventional statistics showed that PAX9 SNP -912 C/T and the MSX1 SNP changed the incidence of hypodontia, although after Bonferroni correction for multiple hypothesis testing, the effects were only borderline tendencies. Using a statistical analysis better suited for handling multiple hypotheses, the BN-BMLA, PAX9 SNPs clearly showed a synergistic effect. This was confirmed by other multivariate analyses and it remained significant after corrections for multiple hypothesis testing (p < 0.0025). The PAX9-1031-A-PAX9-912-T haplotype was the most relevant combination causing hypodontia. Interaction was weaker between PAX9 and MSX1, while other SNPs had no joint effect on hypodontia. CONCLUSION: This complex analysis shows the important role of PAX9 and MSX1 SNPs and of their interactions in tooth agenesis, while IRF6, FGFR1 and AXIN2 SNPs had no detectable role in the Hungarian population. These results also reveal that risk factors in hypodontia need to be identified in various populations, since there is considerable variability among them.

[Oral health assessment of Hungarian adult population based on epidemiologic examination]. / A hazai felnott lakosság parodontális allapota epidemiológiai felmérés alapján.

A representative national survey by the dentists of the Department of Prosthodontics, Semmelweis University was performed to assess oral health conditions of Hungarian adult population before joining the European Union. The aim of this study was to evaluate periodontal conditions of the population from data collected in the survey and to investigate the associations between gender, age and demographic regions and the prevalence of periodontal problems. The 2 years long nationwide investigation followed the WHO criteria (World Health Organization, 1997) and assessed 4606 person throughout all regions of the country. Periodontal conditions and treatment needs of 4153 person were assessed in intraoral examinations by Community Periodontal Index (CPI) method. Age, gender, demographic regions were recorded on questionnaires. According to our findings CPI 2 was the most frequent finding in all age groups which primarily reflected poor oral hygiene. When we consider gender differences, CPI 3 and CPI 4 were more frequent among males while women had CPI 0 and CPI 2 with higher frequency. Our findings reflect regional differences of periodontal health conditions as 16% of the population of the capitol and its surroundings had healthy periodontal condition however we could find CPI 0 only in 5-8% of Middle and South-Danubium population. Findings of our epidemiologic survey call attention on poor oral hygene of the population. There is a need in Hungary for better oral health education of the population, more preventive programs and action plans to promote regular dental office attendance.

[Risk assessment of periodontal disease in Hungary]. / A hazai felnott lakosság fogágyállapotának és a parodontális státuszt befolyásoló rizikótényezok öszefüggéseinek vizsgálata.

In this study, risk determinants were assessed for periodontal disease in the oral health survey of a representative Hungarian adult population sample. 4153 individuals participated in the study after formal consent. Participants were questionned on level of education, dental office attendance, smoking habits, oral hygiene habits and general health conditions. Quality of fixed partial dentures (FPD) were evaluated. Periodontal health status was assessed with the CPI method according to WHO criteria. When the prevalence of CPI scores was assessed by educational level, significant differences were found between groups. With increasing levels of education, a significantly higher percentage of subjects visited the dental office regularly. Higher prevalence of CPI 0 was found among those with higher level of education but there was also high prevalence of CPI 2, representing bad oral hygiene in the highly educated group. Findings of our study showed high percentage (66%) of the population attending the dental office only in case of emergency. The investigation revealed destructive effect of unsatisfactory construction of FPD on the periodontium. Healthy periodontium (CPI 0) was found among 16% of those wearing no FPD and 9% among FPD-wearers. The prevalence of deep periodontal pockets (CPI 4) was 1,6 times higher among smokers as non-smokers. Oral health statistics play an important role in planning for improvement of dental health care. Hungary needs effective prevention programs and emphasize on regular dental office attendance of individuals to improve the nation's oral health status.

[Treatment options of missing teeth resulting from hypodontia. Literature overview I]. / A hypodontia következtében létrejött foghiány ellátásának lehetôségei. Irodalmi áttekintés I.

Nowadays there is an increased need to identify genetic polimorphisms, the underlying genetic factors of hypodontia. This article aims to describe the genetic components of hypodontia, the most frequent congenital tooth development disorder, as well as its interdisciplinary treatment. Congenitally missing teeth may cause serious emotional and physical problems particularly during adolescence. To prevent this, the early diagnosis and the development of definitive treatment plan are vital. In this work the interdisciplinary management involving a dental team plays a crucial role. The most important first step in hypodontia management is to decide whether to apply space closure or space opening when making room for fixed restorations and implants.

[Treatment options of missing teeth resulting from hypodontia. Literature overview II]. / A hypodontia következtében létrejött foghiány ellátásának lehetoségei. Lrodalmi attekintés II.

Congenital hypodontia may cause serious emotional and physical problems which can become particularly grave during adolescence. This article highlights the importance of early diagnosis and the prevention of the progress of the state, and discusses a variety of definitive treatment plans. The aim of restorative dentistry is to restore function, improve appearance and prevent complications caused by hypodontia. When developing a treatment plan, first the severity of hypodontia, the number of missing teeth, and some other factors have to be considered. This can be followed by the treatment, which involves an interdisciplinary dental team.