RESUMO
Introdução: a pré-eclâmpsia (PE) é um distúrbio grave, com fisiopatologia ainda não bem compreendida, de elevada incidência e pode causar sérias consequências para a gestante e para o feto. Objetivo: descrever e analisar as características clínicas e sociodemográficas das gestantes com PE atendidas na maternidade de um hospital referência na região centro-oeste de Minas Gerais, bem como a epidemiologia da doença, os desfechos clínicos neonatais e das gestantes e as condutas terapêuticasrealizadas. Métodos: foi realizado estudo retrospectivo descritivo a partir da análise de prontuários médicos. Resultados: foi obtida incidência de PE de 1,44% na instituição. Entre as gestantes atendidas, 97,9% apresentaram níveis pressóricos compatíveis com PE. Não foram evidenciadas alterações laboratoriais significativas. Somente 8%das gestantes sofreram hemorragia pós-parto, 2% sofreram internação em centro de terapia intensiva e não houve algum óbito materno. Os desfechos neonatais foram mais desfavoráveis, com 25,3% de internação em centro de terapia intensiva e 7% de óbito do recém-nascido. Apenas 18% das parturientes tiveram uso de medicação para prevenireclâmpsia. Conclusão: o estudo permitiu evidenciar a necessidade de implementação de protocolo de atendimento e manejo para PE, a fim de promover melhorias e consolidar a assistência às pacientes usuárias do serviço em questão.
Introduction: preeclampsia (PE) is a serious disorder with little-understood pathophysiology,of high incidence and that can cause serious consequences for the pregnant woman and fetus. Objective: to describe and analyze the clinical and socio-demographic characteristics of pregnant women with PE assisted in the maternity ward of a referral hospital in central-western Minas Gerais as well as the disease epidemiology, neonatal and mother clinical outcomes, and therapeutic proceduresperformed. Methods: this was a retrospective descriptive study based on the analysis of medical records. Results: a PE incidence of 1.44% was observed in the institution. Among the pregnant women, 97.9% had blood pressure levels compatible with PE. Significant laboratory abnormalities were not observed. Only 8% of pregnant women suffered postpartum hemorrhage, 2% have been hospitalized in the intensive careunit, and there was no maternal death. The neonatal outcomes were less favorable with 25.3% hospitalizations in the intensive care unit and 7% newborn deaths. Only 18% of mothers used medication to prevent eclampsia. Conclusion: the study highlighted the need to implement a PE protocol and management in order to promote improvements and consolidate assistance to patients assisted in this service.
RESUMO
Cervical uterine cancer is the second most frequent form of cancer in the female population and the fourth cause of cancer deaths among Brazilian women. In Divinópolis county, Minas Gerais state, cervical cancer accounted for 6.6% of deaths in 2007. The purpose of this study was to conduct an epidemiological and molecular investigation of samples of pre-neoplastic and neoplastic cervical uterine lesions from patients assisted at public healthcare services in the county. The study was based on clinical-epidemiological descriptions retrieved from cytological examination request forms from 2006 to 2010. For molecular analysis, samples from 95 patients were collected and DNA was extracted using the Chelex 100 method. PCR was performed for detection and typing of HPV 6/11, 16, 18, 31, and 33. Of the 52 168 patients who underwent cytological examination, 625 had pre-neoplastic or neoplastic lesions during the study period. Age distribution was consistent with the literature, with a predominance of patients aged 20-49 years. The microorganism found most frequently was Lactobacillus sp. (65%). Prominent among cellular alterations were cervical intraepithelial neoplasia I (39.7%) and atypical squamous cells of undetermined significance (32%). Molecular analysis revealed 72.6% of positive samples for HPV. HPV 16 (26.3%) was the most frequent type, followed by types 6/11 (7.4%), 18 (5.3%), 33 (2.1%), and 31 (1%). The results provided improved understanding of the association between HPV and cancer in Divinópolis, in addition to providing data that can contribute to the design of measures to prevent and control HPV infection in the county investigated.
