A protocol for the prospective study of urinary cadmium with risk of fracture, bone loss, and muscle loss.

Cadmium (Cd) is a heavy metal and natural element found in soil and crops with increasing concentrations linked to phosphate fertilizers and sewage sludge applied to crop lands. A large fraction of older US men and woman have documented Cd exposure. Cd exposure has proven health concerns such as risk of lung cancer from inhalation and impaired renal function; however, growing evidence suggests it also influences bone and muscle health. Given that low levels of Cd could affect bone and muscle, we have designed prospective studies using the two largest and most detailed US studies of bone health in older men and women: the Osteoporotic Fractures in Men Study and the Study of Osteoporotic Fractures. We are investigating the association of urinary cadmium (U-Cd), as a surrogate for long-term Cd exposure, with bone and muscle health. Building off suggestive evidence from mechanistic and cross-sectional studies, this will be the first well-powered prospective study of incident fracture outcomes, bone loss, and muscle loss in relation to U-Cd, an established biomarker of long-term Cd exposure. The following is a proposed protocol for the intended study; if successful, the proposed studies could be influential in directing future US policy to decrease Cd exposure in the US population similar to recent policies adopted by the European Union to limit Cd in fertilizers.

Urine antimony and risk of cardiovascular disease - A prospective case-cohort study in Danish Non-Smokers.

BACKGROUND: Limited evidence suggests that antimony induces vascular inflammation and oxidative stress and may play a role in cardiovascular disease (CVD) risk. However, few studies have examined whether environmental antimony from sources other than tobacco smoking is related with CVD risk. The general population may be exposed through air, drinking water, and food that contains antimony from natural and anthropogenic sources, such as mining, coal combustion, and manufacturing. OBJECTIVES: To examine the association of urine antimony with incident acute myocardial infarction (AMI), heart failure, and stroke among people who never smoked tobacco. METHODS: Between 1993 and 1997, the Danish Diet, Cancer and Health (DCH) cohort enrolled participants (ages 50-64 years), including n = 19,394 participants who reported never smoking at baseline. Among these never smokers, we identified incident cases of AMI (N = 809), heart failure (N = 958), and stroke (N = 534) using the Danish National Patient Registry. We also randomly selected a subcohort of 600 men and 600 women. We quantified urine antimony concentrations in samples provided at enrollment. We used modified Cox proportional hazards models to estimate adjusted hazard ratios (HR) for each incident CVD outcome in relation to urine antimony, statistically adjusted for creatinine. We used a separate prospective cohort, the San Luis Valley Diabetes Study (SLVDS), to replicate these results. RESULTS: In the DCH cohort, urine antimony concentrations were positively associated with rates of AMI and heart failure (HR = 1.52; 95%CI = 1.12, 2.08 and HR = 1.58; 95% CI = 1.15, 2.18, respectively, comparing participants in the highest (>0.09 µg/L) with the lowest quartile (<0.02 µg/L) of antimony). In the SLVDS cohort, urinary antimony was positively associated with AMI, but not heart failure. DISCUSSION: Among this sample of Danish people who never smoked, we found that low levels of urine antimony are associated with incident CVD. These results were partially confirmed in a smaller US cohort.

Priorities for Bolstering Public Health Resilience in the Context of Climate Change in Dominica and Puerto Rico.

Caribbean small island developing states are highly exposed to climate change impacts. Incorporating weather and climate information into public health decisions can promote resilience to climate change's adverse health effects, but regionally it is not common practice. We implemented a project to enhance dialogue between climate and public health specialists in Puerto Rico and Dominica. First, we conducted environmental scans of public health vulnerability in the context of weather and climate for both islands. Then, we convened stakeholders to discuss the scan results and identify priorities for climate and health. A shared priority was increasing climate and health knowledge; thus, we developed several educational initiatives. In this viewpoint, we discuss our process for conducting environmental scans, building capacity and partnerships, and translating knowledge-to-action around climate and health.

Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH) Cohort Study: influences of complex environmental exposures on maternal and child health in Suriname.

PURPOSE: The Caribbean Consortium for Research in Environmental and Occupational Health prospective environmental epidemiologic cohort study addresses the impact of chemical and non-chemical environmental exposures on mother/child dyads in Suriname. The study determines associations between levels of environmental elements and toxicants in pregnant women, and birth outcomes and neurodevelopment in their children. PARTICIPANTS: Pregnant women (N=1143) were enrolled from December 2016 to July 2019 from three regions of Suriname: Paramaribo (N=738), Nickerie (N=204) and the tropical rainforest interior (N=201). Infants (N=992) were enrolled at birth. Follow-up will take place until children are 48 months old. FINDINGS TO DATE: Biospecimens and questionnaire data on physiological and psychosocial health in pregnant women have been analysed. 39.1% had hair mercury (Hg) levels exceeding values considered safe by international standards. Median hair Hg concentrations in women from Paramaribo (N=522) were 0.64 µg/g hair (IQRs 0.36-1.09; range 0.00-7.12), from Nickerie (N=176) 0.73 µg/g (IQR 0.45-1.05; range 0.00-5.79) and the interior (N=178) 3.48 µg/g (IQR 1.92-7.39; range 0.38-18.20). 96.1% of women ate fish, respective consumption of the three most consumed carnivorous species, Hoplias aimara, Serrasalmus rhombeus and Cichla ocellaris, known to have high Hg levels, was 44.4%, 19.3% and 26.3%, respectively, and was greater among the interior subcohort. 89% frequently consumed the vegetable tannia, samples of which showed presence of worldwide banned pesticides. 24.9% of pregnant women had Edinburgh Depression Scale scores indicative of probable depression. FUTURE PLANS: Fish consumption advisories are in development, especially relevant to interior women for whom fish consumption is likely to be the primary source of Hg exposure. Effects of potentially beneficial neuroprotective factors in fish that may counter neurotoxic effects of Hg are being examined. A pesticide literacy assessment in pregnant women is in progress. Neurodevelopmental assessments and telomere length measurements of the children to evaluate long-term effects of prenatal exposures to toxicant mixtures are ongoing.

Association of groundwater constituents with topography and distance to unconventional gas wells in NE Pennsylvania.

Recently we reported an association of certain diseases with unconventional gas development (UGD). The purpose of this study is to examine UGD's possible impacts on groundwater quality in northeastern Pennsylvania. In this study, we compared our groundwater data (Columbia 58 samples) with those published data from Cabot (1701 samples) and Duke University (150 samples). For each dataset, proportions of samples with elevated levels of dissolved constituents were compared among four groups, identified as upland far (i.e. ≥1km to the nearest UGD gas well), upland near (<1km), valley far (≥1km), and valley near (<1km) groups. The Columbia data do not show statistically significant differences among the 4 groups, probably due to the limited number of samples. In Duke samples, Ca and CI levels are significantly higher in the valley near group than in the valley far group. In the Cabot dataset, methane, Na, and Mn levels are significantly higher in valley far samples than in upland far samples. In valley samples, Ca, Cl, SO4, and Fe are significantly higher in the near group (i.e. <1km) than in the far group. The association of these constituents in valley groundwater with distance is observed for the first time using a large industry dataset. The increase may be caused by enhanced mixing of shallow and deep groundwater in valley, possibly triggered by UGD process. If persistent, these changes indicate potential for further impact on groundwater quality. Therefore, there is an urgent need to conduct more studies to investigate effects of UGD on water quality and possible health outcomes.

The Deepwater Horizon Oil Spill Through the Lens of Human Health and the Ecosystem.

This review examines current research ascertaining the impact of the Deepwater Horizon oil spill on human health and ecosystems. Driven by the need to strategically focus research funding, the authors also assess the implications of those findings and promote a transdisciplinary research agenda addressing critical gaps.Epidemiologic studies conducted in workers and vulnerable communities in the spill's aftermath showed that non-chemical stressors affect resilience. Ecosystem-wise salt marsh species showed variability in structural and functional changes, attributed to species-specific tolerance, oil exposure, and belowground plant organs damage.Lacking baseline exposure assessment data hampers assessing the impact of chemical stressors. Research priorities include leveraging existing women/child dyads and worker cohorts to advance exposure characterization and counter early adverse effects in most vulnerable populations. Key policy gaps include mandated just-in-time emergency resources to ascertain immediate post-event exposures and contemporary legislation addressing human and ecosystem health in an integrated rather than silo fashion.

HIV/AIDS among the elderly: stigmas in healthcare work and training / HIV/aids em idosos: estigmas, trabalho e formação em saúde

Abstract The number of HIV/AIDs diagnoses among the elderly is currently increasing both in Brazil and on a global level. The present article describes the results of a qualitative study which aimed to assess the role of health professionals on elderly patients diagnosed with HIV/AIDS receiving treatment via the public health service. Nine professionals who made up a specialized HIV/AIDS service in a medium-sized city in the state of Minas Gerais were interviewed. Their statements were subjected to content analysis, and the results suggested that according to the perceptions of the health professionals, the main impacts of the diagnosis of HIV/AIDS are linked to isolation, loneliness, prejudice, fear of revealing the diagnosis and the decrease or interruption of sexual practices. The professionals reported being overburdened both psychologically and in terms of workload, having difficulty addressing aspects of sexuality and sexual practices with the elderly, and admitted to possessing certain stereotypes and prejudices related to HIV/AIDS and the sexuality of the elderly. Through results analysis, it was concluded that the stigma and prejudice related to HIV and the sexuality of the elderly are intimately present in the work processes of the professionals interviewed, impacting on the treatment of such individuals and interfering with their health and illness processes. The discussion of these aspects should be included in health training strategies. AU

Resumo Atualmente, no cenário mundial e no Brasil, registra-se um aumento do número de diagnósticos de HIV/aids em idosos. Este artigo apresenta resultados de uma pesquisa qualitativa que buscou analisar a atuação de profissionais de saúde em idosos com diagnóstico de HIV/aids em um serviço público de saúde. Foram entrevistados os nove profissionais que compõem um serviço público de assistência especializada em HIV/aids de um município de porte médio de Minas Gerais. As falas foram submetidas à análise de conteúdo e a análise dos resultados permite afirmar que, na percepção dos profissionais de saúde, os principais impactos do diagnóstico de HIV/aids estão vinculados ao isolamento, solidão, preconceito, medo da revelação do diagnóstico e desaceleração ou interrupção das práticas sexuais. Os profissionais relatam sobrecarga de trabalho e sobrecarga psíquica, dificuldades em abordar aspectos da sexualidade e práticas sexuais com idosos e admitem compartilhar alguns estereótipos e preconceitos vinculados ao HIV/aids e à sexualidade da pessoa idosa. Pela análise dos resultados, pode-se concluir que os estigmas e preconceitos vinculados ao HIV e à sexualidade da pessoa idosa estão intimamente presentes no processo de trabalho dos profissionais entrevistados, impactam o tratamento e interferem nos processos de saúde e adoecimento. A discussão sobre esses aspectos deve compor as ações de formação em saúde. AU

Psychosocial impact of HIV/aids diagnosis on elderly persons receiving care from a public healthcare service / Impacto psicossocial do diagnóstico de HIV/aids em idosos atendidos em um serviço público de saúde

The current increase in the number of elderly people infected with the human immunodeficiency virus (HIV) represents a major challenge to healthcare professionals, public policies and the general population, in terms of the need to discuss the role of sexuality and sexual practices in the aging process and the impact of these issues on health promotion for the elderly. The aim of the present study was to identify the psychosocial impact of HIV/Aids diagnosis on elderly persons receiving care in a public healthcare service, based on the perception of the individuals themselves. A qualitative research study of an exploratory nature was performed, based on individual semi-structured interviews with HIV-positive elderly patients, living in the mid-west macro-region of Minas Gerais. Analysis of the results suggested that, according to the 14 patients interviewed, HIV diagnosis involves changes in the way they relate to people; in self-care; in sexual practices; in the performance of daily activities and in the possibility of continuing to participate in social groups. The patients reported embarrassment, fear of rejection and discrimination, and experiences of isolation and facing prejudice. Based on the results, it can be concluded that most of the problems faced by older people are linked to socially constructed stigmas and stereotypes associated with the disease and the efforts made by such individuals to keep the diagnosis a secret.

O atual avanço do número de pessoas idosas infectadas pelo vírus da imunodeficiência humana (HIV) representa um desafio aos profissionais de saúde, às políticas públicas e à população em geral no que concerne à necessidade de discutir sexualidade, práticas sexuais no processo de envelhecimento e o impacto dessas questões na promoção de saúde da pessoa idosa. Esta pesquisa teve como objetivo identificar os impactos psicossociais do diagnóstico de HIV/aids em pessoas idosas em atendimento em um serviço público de saúde, a partir da percepção dos sujeitos entrevistados. O estudo caracterizou-se como uma pesquisa qualitativa de caráter exploratório. Foram realizadas entrevistas individuais semiestruturadas com pacientes idosos soropositivos para HIV, residentes na macrorregião Centro-Oeste de Minas Gerais. A análise dos resultados permite afirmar que, de acordo com os 14 pacientes entrevistados, o diagnóstico de HIV/aids implica uma reorganização na maneira como se relacionam com pessoas; no autocuidado; nas práticas sexuais; na realização de atividades cotidianas e nas possibilidades de manterem sua participação em grupos sociais. Relatam constrangimento, medo da rejeição e discriminação, experiências de isolamento e preconceitos enfrentados. Com base na análise dos resultados, pode-se concluir que a maioria dos problemas enfrentados pelos idosos está vinculada aos estigmas e estereótipos socialmente construídos em relação à doença e aos esforços empreendidos pelos mesmos para manter o diagnóstico em segredo.