RESUMO
The influence of newly synthesized compound--thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate (FS-169), which has a direct anticoagulant--on the indices of coagulation activity has been studied in rabbit blood plasma with the aid of an APG4-02-P coagulometer. It is established that FS-169 reliably extends the partial thromboplastin time by 122.2% (p < 0.001) and the prothrombin time by 49.1% (p = 0.001), increases the prothrombin index by 30.9% (p = 0.001), and decreases the prothrombin ratio and international normalized ratio by 40.0% (p = 0.001). At the same time FS-169 does not influence the thrombin time FS-169.
Assuntos
Acetatos/farmacologia , Anticoagulantes/farmacologia , Derivados de Benzeno/farmacologia , Coagulação Sanguínea/efeitos dos fármacos , Tempo de Protrombina , Compostos de Vinila/farmacologia , Animais , CoelhosRESUMO
We studied the effects of subcutaneous and intragastrical administration of synthesized compound thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate (FS 169) on blood clotting in vitro and in vivo in rabbits. Compound FS 169 significantly prolongs clotting time in vitro; its activity is comparable with that of heparin. When administered subcutaneously, the substance is rapidly absorbed and significantly reduces blood clotting by 102.9% from the initial clotting time within 30 min. After intragastric administration of the substance, maximum activity (133.0% of the baseline clotting time) was observed in 30 min after administration. The drug effect upon subcutaneous and intragastrical administration lasted for 2 h.
