[Morphology of the growth of heterotransplants of human ovarian cancer in diffusion chambers]. / Morfologiia rosta geterotransplantatov raka iaichnika cheloveka v diffuzionnykh kamerakh.

The diffusion chamber study of the morphology of the growth of ovarian cancer heterotransplants from 15 patients resulted in identification of two types of the growth. In 8 cases the growth of the epithelial cells was seen. The cells covered the entire filter surface, forming the typical pattern. In 6 cases the fibroblast-like cells were seen among the areas of the epithelial cells that showed marked polymorphism. The similar patterns were recorded in culture of human ovarian cancer in vitro.

[Effect of hypophysectomy, hypophyseal explants and ACTH on the growth of human melanomas in diffusion chambers]. / Vliianie gipofizéktomii, éksplantatov gipofiza i AKTG na rost melanom cheloveka v diffuzionnykh kamerakh.

Under study was the hypophysis influence on the growth of human melanoma explants, cultivated in the abdominal cavity of mice and rats. The heterotransplants growth was compared in intact and hypophysectomized animals exposed to ACTH, and also the effect of the murine hypophysis explanted into the adjacent chamber compartments on the melanoma explants growth was investigated. The growth was assessed by a square area of the explants growth zones. ACTH and the hypophysis explanted were found to render a stimulating effect on the growth of tumor heterotransplants. Hypophysectomy in rats would suppress the growth of all melanoma explants under investigation. When injecting ACTH into hypophysectomized animals the growth of melanoma heterotransplants in the chambers does not differ from that in control series.

[The sensitivity of human melanoma heterotransplants to chemotherapeutic action]. / Chuvstvitel'nost' geterotransplantatov melanom cheloveka k khimioterapevticheskomu vozdeistviiu

There were revealed considerable individual differences in the sensitivity of human melanomas cultivated in diffusion chambers in the abdominal cavity of mice and the explants into the cheek pouches of Cricetus auratus W. to the combined action of three drugs: vincristin (or vinblastin), nitrosomethylurea, and dactinomycin. In comparing the results obtained in these two variants of investigations they proved to coincide in 3 of 5 cases. In 2 cases a negative result obtained in experimentas with Cricetus auratus W. corresponded to the positive result in experiments with diffuse chambers.