[HLA antigens in juvenile rheumatoid arthritis]. / Antigeny sistemy HLA pri iuvenil'nom revmatoidnom artrite.

Antigens of I class HLA system (locus A and B) were investigated in 67 patients of Latvian nationality suffering from juvenile rheumatoid arthritis (JRA). Associations of HLA antigens with juvenile rheumatoid arthritis partially coincided with the ones revealed earlier. Typing established an increased incidence of antigen B27 (p less than 0.01) and gaplotype A2, B40 (p less than 0.01). Antigen B15 possessed a protective action with respect to JRA. Interlocus combinations demonstrated a closer association with the disease than a single antigen. The authors also revealed markers of various clinico-anatomical variants of JRA.

[The immune status of children with differing intensities of caries]. / Immunnyi status u detei s razlichnoi intensivnost'iu kariesa.

The present paper reports on the results of the studies of the quantity, functional activity of immunocytes and interrelation between their parameters in healthy children (12-14) with healthy periodontium which were ascribed either to caries-resistant or caries-prone group. In all the subjects venous blood and mixed saliva were investigated. Immune state was described through its parameters interrelations. This yields better detection of differences in immune states of both groups.

[The lymphocytotoxic test as a method of identifying subpopulations of T lymphocytes using monoclonal antibodies]. / Limfotsitotoksicheskii test kak metod identifikatsii subpopuliatsii T-limfotsitov monoklonal'nymi antitelami.

The authors analyse the findings of the lymphocytotoxicity test with monoclonal antibodies and the indirect immunofluorescence method used for the assays of T lymphocyte subpopulations. The mean values of the total count of T lymphocytes, T helpers, T suppressors, as well as the immunoregulation index obtained by both methods have proved practically the same. The lymphocytotoxicity data have been in good correlation with the findings of indirect immunofluorescence in tests with all the monoclonal OCT antisera.

[Chronic T-cell lymphoid leukemia with helper cell phenotype]. / T-kletochnyi khronicheskii limfoleikoz s khelpernym fenotipom kletok.

Tumour cells of a patient with T-cell chronic lymphocytic leukemia had surface (E+, OKT3+, OKT4+, OKT8-, SIg-, Ia-) and cytochemical (properties positive reaction to acid phosphatase, acid nonspecific esterase and negative reaction to terminal deoxynucleotidyl transferase) specific for T-helper lymphocytes. They had no activity of NK and K-cells, reacted weakly to mitogens (PHA, Con A, PWM) and allogenic cells. Con A and PWM stimulated synthesis of specific receptors (OKT3 and OKT4) on the surface of malignant cells, whereas PHA decreased the amount of above receptors.

[Isolation of purified populations of T- and B-lymphocytes under clinical conditions]. / Vydelenie ochishchennykh populiatsii T- i B-limfotsitov v klinicheskikh usloviiakh.

The authors present comparative characteristics of the methods of isolation of T- and B-lymphocytes in patients with chronic renal insufficiency. T-lymphocytes were obtained on columns with neilon cotton wool. B-cells were fractionated by repeated centrifugation in the gradient of phycol-urotrast density after staging E-rosette formation with the total lymphocyte pool. Methodical peculiarities of single-stage and two-stage B-lymphocyte fractionation were revealed.