[Decrease in the degree of lipoid infiltration of rabbit tissues during feeding with cholesterol freed from autoxidation products]. / Snizhenie stepeni lipoidnoi infil'tratsi tkanei krolikov pri skarmlivanii kholesterina, osvobozhdennogo ot produktov ego okisleniia.

Lipid accumulation in the rabbit liver and myocardium has been investigated by histochemical and biochemical methods. The rabbits received cholesterol that contained 5% of autooxidation products or purified cholesterol. Lipid accumulation took place in the liver and intramural myocardial vessels during feeding of rabbits with autooxidated cholesterol. Feeding with pure cholesterol free from autooxidation products caused but slight changes or no changes at all.

[Effect of cholesterol oxidation products, polyunsaturated fatty acids and the synthetic antioxidant ionol on experimental hypercholesterolemia in rabbits]. / Vliianie produktov okisleniia kholesterina, polinenasyschennykh zhirnykh kislot i sinteticheskogo antioksidanta ionola na éksperimental'nuiu giperkholesterinemiiu u krolikov.

Oral administration to rabbits of purified commercial cholesterol entailed a substantial delay in the development of hypercholesterolemia as compared with estimates obtained in a group of animals given analogous doses of crude cholesterol. Administration of polyunsaturated fatty acids from hydrobiont lipids led to a dramatic suppression of hypercholesterolemia at the late stages of experiment (2.5 months). After administering ethyl esters of polyunsaturated fatty acids combined with the synthetic antioxidant ionol the level of blood plasma cholesterol did not differ significantly from that in intact animals. It is suggested that minor oxidation products contained by commercial cholesterol produce a hypercholesterolemic effect.