Assuntos
Oxigenoterapia/história , Oxigênio/história , Oxigênio/uso terapêutico , Pneumologia/história , Transtornos Respiratórios/história , Transtornos Respiratórios/terapia , Europa (Continente) , História do Século XVII , História do Século XVIII , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Estados UnidosRESUMO
Gastro-oesophageal reflux disease (GERD) is one of the most common clinical conditions in the developed countries. Particular interest in pulmonary manifestations of this disease has arisen over the last few years. Although the high coincidence between reflux and chronic cough is unquestioned, the proof of a causal correlation is still lacking. In this paper we present the Marburger Lung-Sound-Monitoring as a new method for the detection of nocturnal respiratory symptoms such as cough, wheezing and throat clearing and their temporal correlation with reflux. This method will in future allow us to precisely record and to evaluate the extent and duration of reflux events and their correlation with respiratory symptoms.
Assuntos
Refluxo Gastroesofágico/complicações , Monitorização Ambulatorial/instrumentação , Polissonografia/instrumentação , Sons Respiratórios , Processamento de Sinais Assistido por Computador/instrumentação , Desenho de Equipamento , Determinação da Acidez Gástrica/instrumentação , Refluxo Gastroesofágico/fisiopatologia , Alemanha , Humanos , Sons Respiratórios/fisiopatologia , SoftwareRESUMO
Familial adenomatous polyposis is an autosomal dominant disease that primarily involves the colon, but may involve other organs such as the central nervous system, ampulla of Vater, liver, soft tissue and the remainder of the gastrointestinal tract. In this report we present the adenocarcinoma of the uterus and adenocarcinoma of the ovary as a new addition to the clinical spectrum of familial adenomatous polyposis. Due to the tendency for development of multiple primary carcinomas in patients with familial adenomatous polyposis, these patients need to be followed very closely for detection of new malignancies. If diagnosed early and treated accordingly, they could have a long-term postoperative survival.
Assuntos
Adenocarcinoma/genética , Polipose Adenomatosa do Colo/genética , Neoplasias do Endométrio/genética , Segunda Neoplasia Primária/genética , Neoplasias Ovarianas/genética , Adulto , Feminino , Genótipo , Humanos , FenótipoRESUMO
The syndrome of familial adenomatous polyposis has a wide spectrum of clinical manifestations including adenomatous polyps of the colon and small bowel, adenocarcinoma of ampulla of Vater, tumors of the central nervous system, bone lesions, and various soft tissue tumors. The one common denominator is colonic polyposis. It is not known whether this phenotypic heterogeneity is due to various genotypes, or if the entire clinical spectrum is due to one genetic defect. We are reporting the association of gynecologic malignancies with familial adenomatous polyposis as an additional variant of this disease. This report is on two sisters from a family with familial polyposis coli who developed adenomatous polyposis of the colon, central nervous system tumors, and cancers of the ovary and uterus. The gynecological malignancies add another variant to this clinical syndrome.
