RESUMO
The study established that shifts in oxidant-antioxidant system induced by chronic obstructive bronchitis are correctable by He-Ne laser irradiation. This conclusion was based on biochemical indices of the blood measured in experimental animals: lipid peroxidation, general antitryptic activity of the serum, activity of the enzymes superoxide dismutase, gamma-glutamyl transferase, pseudocholine esterase, alpha-oxybutyrate dehydrogenase, glucose 6-phosphate dehydrogenase.
Assuntos
Antioxidantes , Bronquite/radioterapia , Terapia a Laser , Animais , Fenômenos Bioquímicos , Bioquímica , Bronquite/sangue , Butirilcolinesterase/sangue , Glucosefosfato Desidrogenase/sangue , Hidroxibutirato Desidrogenase/sangue , Peroxidação de Lipídeos , Ratos , Superóxido Dismutase/sangue , gama-Glutamiltransferase/sangueRESUMO
The authors investigated the clinical and biochemical efficacy of millimeter-wave resonance therapy in patients with destructive pulmonary tuberculosis associated with different concomitant diseases. It was established that inclusion of millimeter-wave resonance therapy in the complex treatment of this patient category favoured the efficacy of tuberculosis treatment. The treatment produced also a favourable effect on concomitant diseases.
Assuntos
Micro-Ondas/uso terapêutico , Tuberculose Pulmonar/terapia , Terapia Combinada , Quimioterapia Combinada , Humanos , Indução de Remissão , Tuberculose Pulmonar/complicaçõesAssuntos
Bronquite/terapia , Diatermia , Micro-Ondas/uso terapêutico , Tuberculose Pulmonar/terapia , Adulto , Bronquite/complicações , Bronquite/metabolismo , Doença Crônica , Terapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Oxirredução , Tuberculose Pulmonar/complicações , Tuberculose Pulmonar/metabolismoRESUMO
The efficacy of a combined use of isoniazid together with polyzid prolonged tuberculostatic and tricarboxylic acid cycle metabolites was experimentally studied in guinea pigs. Mortality rates, pathomorphologic test data and the extent of tuberculous affection in the animals confirm a fairly high efficacy of prolonged polyzid in combination with succinate and malate as pathogenetic drugs.
Assuntos
Antituberculosos/administração & dosagem , Isoniazida/administração & dosagem , Maleatos/administração & dosagem , Succinatos/administração & dosagem , Tuberculose Pulmonar/tratamento farmacológico , Animais , Preparações de Ação Retardada , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada , Cobaias , Masculino , Compostos Orgânicos , Ácido SuccínicoAssuntos
Isoniazida/uso terapêutico , Animais , Preparações de Ação Retardada , Avaliação Pré-Clínica de Medicamentos , Cobaias , Isoniazida/farmacocinética , Isoniazida/toxicidade , Dose Letal Mediana , Fígado/patologia , Pulmão/patologia , Masculino , Distribuição Tecidual , Tuberculose/tratamento farmacológico , Tuberculose/mortalidade , Tuberculose/patologiaAssuntos
Isoniazida/farmacologia , Preparações de Ação Retardada , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Resistência Microbiana a Medicamentos , Humanos , Mycobacterium tuberculosis/efeitos dos fármacos , Mycobacterium tuberculosis/crescimento & desenvolvimento , Tuberculose Pulmonar/microbiologiaRESUMO
Effects of isoniazide and of new tuberculostatic drug of long-term action on functions of guinea pig liver mitochondria were studied in experimental tuberculosis. Significant changes in oxidative phosphorylation were found. The combination of sodium succinate with tuberculostatic drugs improved the bioenergetic functions of liver mitochondria under the conditions of antibacterial therapy of experimental tuberculosis.