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2.
Health Care Financ Rev ; 14(4): 169-80, 1993.
Artigo em Inglês | MEDLINE | ID: mdl-10133108

RESUMO

This article demonstrates a method for evaluating the predictive validity of nursing home pre-admission screens (PAS) by using measures of predictive validity adapted from the field of epidemiology. Our approach estimates how well as PAS performs in identifying the "who but for" population of the Medicaid home and community-based services waiver programs for the frail elderly. The methodology's usefulness in screen revision is also illustrated.


Assuntos
Definição da Elegibilidade/estatística & dados numéricos , Avaliação Geriátrica , Instituição de Longa Permanência para Idosos/estatística & dados numéricos , Medicaid/estatística & dados numéricos , Casas de Saúde/estatística & dados numéricos , Atividades Cotidianas , Idoso , Connecticut , Definição da Elegibilidade/normas , Métodos Epidemiológicos , Feminino , Previsões , Idoso Fragilizado , Instituição de Longa Permanência para Idosos/economia , Humanos , Masculino , Casas de Saúde/economia , Reprodutibilidade dos Testes , Estados Unidos
4.
Horm Metab Res ; 10(4): 344-7, 1978 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-567167

RESUMO

Repeated administration of pregenolone-16alpha-carbonitrile (PCN) induced hepatic microsomal RNA-synthesis in female rats. The RNA that appeared with 14C-orotate in the microsomes after a 12-h pulse had maximal specific activity. Deoxycholate-soluble RNA demonstrated a higher specific activity than did its ribosomal counterpart, and both were significantly more radioactive than in the respective controls. Examination of the rate of 14C-leucine incorporation into microsome-bound polypeptides showed that the enhanced RNA-synthesis after PCN treatment resulted in an augmentation of protein-synthesis. Administration of this cyanosteroid was also associated with a significant decrease in glucose-6-phosphatase activity and an increase in the cholesterol content of rat hepatocellular microsomes, which correlate well with the degranulation of rough endoplasmic reticulum and the synchronous proliferation of smooth endoplasmic reticulum.


Assuntos
Microssomos Hepáticos/metabolismo , Carbonitrila de Pregnenolona/farmacologia , Biossíntese de Proteínas , RNA/metabolismo , Animais , Feminino , Ratos
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