RESUMO
Fifty-seven patients with obliterating diseases of the lower limb arteries were examined. The concentration of lactate in the venous blood and the venous-arterial difference in the blood lactate level in the affected limb were found to be increased. A relationship between the marked character of these shifts and the severity of the ischemic syndrome was noted. The authors discuss the possibility of using the values of the lactate content in the regional blood as criteria for evaluating the efficacy of treatment and the prognosis of obliterating diseases of the lower limb arteries.
Assuntos
Arteriosclerose Obliterante/sangue , Angiopatias Diabéticas/sangue , Endarterite/sangue , Lactatos/sangue , Perna (Membro)/irrigação sanguínea , Adulto , Artéria Femoral , Veia Femoral , Humanos , MasculinoRESUMO
Eighty seven patients with Stages II-III vascular occlusions in the lower extremities were examined. The clinical and biochemical parameters of the course of the disease were found to improve in the patients who received in earlier periods dalargin supplemented to the combined therapy than in those from a matched group. There was a decrease in femoral venous blood lactate concentrations in the diseased extremity, blood cholesterol and parathyroid hormone levels. The mechanisms responsible for effects of dalargin on metabolic parameters and clinical indices of the patients' condition were also discussed. Whether it is possible to use dalargin in the combined therapy for extremity vascular occlusive diseases is considered.
Assuntos
Arteriosclerose Obliterante/tratamento farmacológico , Colesterol/sangue , Leucina Encefalina-2-Alanina/análogos & derivados , Lactatos/sangue , Perna (Membro)/irrigação sanguínea , Hormônio Paratireóideo/sangue , Adulto , Anticolesterolemiantes , Arteriosclerose Obliterante/sangue , Leucina Encefalina-2-Alanina/uso terapêutico , Humanos , Lactatos/antagonistas & inibidores , Masculino , Pessoa de Meia-Idade , Hormônio Paratireóideo/antagonistas & inibidoresRESUMO
The experiments have been performed on 70 male rats weighing 200-250 gr., 53 patients with obliterating atherosclerosis of lower extremities have been examined. Leu-enkephalin analogues (dalargin and DEFN) administration in a dose of 0.1 mg/kg has been determined to decrease cholesterol levels in the blood in acute and chronic experimental hypercholesterolemia. The use of pharmacological preparation -- enkephalin analogue of dalargin in complex treatment of the obliterating atherosclerosis of lower extremities leads to cholesterol concentration decrease, parathormone concentration decrease in the blood of patients and hyperlactatemia decrease in venous blood of the damaged extremity. Leu-enkephalin analogues, action mechanisms and the possibility of their use for atherosclerosis treatment is discussed.
Assuntos
Arteriosclerose Obliterante/tratamento farmacológico , Leucina Encefalina-2-Alanina/análogos & derivados , Encefalina Leucina/análogos & derivados , Adulto , Animais , Arteriosclerose Obliterante/sangue , Colesterol/sangue , Encefalina Leucina/uso terapêutico , Humanos , Lactatos/sangue , Lipoproteínas HDL/sangue , Lipoproteínas LDL/sangue , Lipoproteínas VLDL/sangue , Masculino , Pessoa de Meia-Idade , Hormônio Paratireóideo/sangue , Ratos , Ratos Endogâmicos , Simpatolíticos/uso terapêuticoAssuntos
Leucina Encefalina-2-Alanina/análogos & derivados , Encefalina Leucina/análogos & derivados , Extremidades/irrigação sanguínea , Isquemia/tratamento farmacológico , Simpatolíticos/uso terapêutico , Adulto , Doença das Coronárias/tratamento farmacológico , Encefalina Leucina/uso terapêutico , Humanos , Masculino , Microcirculação , Pessoa de Meia-IdadeRESUMO
On the basis of studying the dynamics of losses in the reserve fat and active body mass during a catabolic phase of the burn disease, in 124 sufferers with the burns of 5 to 80% of the body surface, a classification of the severity degree of lipido-protein deficiency, which distinguishes a compensated, subcompensated and decompensated grade and subdivides the latter into the reversible and irreversible forms, is suggested. The classification permits to assess more objectively the severity of the state and prognosis in burned patients, and as well to define purposefully the methods for correction of the revealed disorders.
Assuntos
Peso Corporal , Queimaduras/fisiopatologia , Lipídeos/deficiência , Deficiência de Proteína/metabolismo , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Parathyroid gland function and the possibility of its correction were studied in 43 patients with obliterative vascular disease of the lower limbs, and in 24 healthy, mostly male, controls. Parathormone (PTH) concentrations in blood plasma samples were determined by radioimmunoassay. Patients with obliterative vascular diseases of the lower limbs were found to have increased activity of parathyroid gland. The role played by hyperparathyroidism in the pathogenesis of obliterative vascular diseases of the lower limbs as well as the possibility of its correction by betablocker and encephalin analogue administration is discussed.