[The role of colposcopy in evaluation of the cervix for unexpectedly positive pap smears]. / Znaczenie kolposkopii w ocenie szyjki macicy z niepodejrzanymi rozmazami cytologicznymi.

The cervical cancer is still one of the most common malignancies of female low genital tract (LGT). Pap smears is a widely used screening procedure. Colposcopy with punch biopsy verifies positive Pap smears. Clinical material were 133 women aged 34-75 yrs diagnosed and operated in the Chair and Department of Gynecology and Oncology CM Jagellonian University. In all cases cytology and colposcopy were performed. Their results were compared to each other and to histology results. The concordance of cytologic and histology results reached 92.5% while of colposcopic and histology--98%. Colposcopy is an useful method of Pap smears verification because it limits to minimum false negative results percentage.

[Chemotherapy and immunomodulating treatment of patients with multiple myeloma]. / Chemioterapia i leczenie immunomodulacyjne u chorych na szpiczaka plazmocytowego.

Prospective studies were carried out on the effectiveness of various treatment methods in 208 patients with plasmocytic myeloma. In 102 patients induction therapy was based exclusively on melphalan, in 106 cases polychemotherapy was used including vincristine, melphalan, carmustine, cyclophosphamide and prednisone. The differences in the per cent of patients with good response to treatment and in the survival time after treatment beginning were statistically not significant between these groups which suggests that polychemotherapy begun from the diagnosis of the disease is justified in patients with large mass of the neoplasm and poor prognostic factors. In 45 patients chemotherapy was supported by administration of immunomodulatory agents, including calf thymus extract in 25 cases, levamisole in 18 and interferon in 2. It was observed that maintenance of remission with chemotherapy and with immunomodulatory agents calf thymus extract or levamisole prolonged the survival of the patients. In cases of leucopenia the use of calf thymus extract facilitated chemotherapy by stimulation of myelopoiesis.

[Clinical and laboratory analysis of the cases of multiple myeloma with over 5-year survival time from the beginning of the antineoplastic treatment]. / Analiza kliniczna i laboratoryjna przypadków szpiczaka plazmocytowego z czasem przezycia powyzej 5 lat od rozpoczecia leczenia przeciwnowotworowego.

Out of 436 studied patients with plasmocytic myeloma 67 (15.0%) survived over 5 years from the beginning of antineoplastic treatment, and 18 survived over 10 years from the first symptom of the proliferative process. The patients with long survival were younger at the time of diagnosis than the whole studied group and had normal creatinine and calcium levels in the serum. Nearly half these patients had I or II stage of clinical progression and IgG monoclonal protein. Treatment with melphalan only was given to 17 patients, 33 were treated with melphalan, followed by vincristine, cyclophosphamide, BCNU, prednisone and doxorubicin. Polychemotherapy was given from the time of the diagnosis to 13 patients, and 4 received radiotherapy or 60Co irradiation besides chemotherapy. In 81% of the analysed cases a good response was obtained. Thirteen patients are alive. In 5 cases myeloid leukaemia, in 1 case bronchogenic carcinoma and in 1 case liver carcinoma were the causes of death.