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2.
Andes Pediatr ; 92(6): 854-861, 2021 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-35506796

RESUMO

INTRODUCTION: COVID-19 pandemic has meant adapting to a different reality, with long-term lockdowns that might cause an increase of burns in children at home. OBJECTIVE: To compare the epidemiological situation of patients admitted to the Corporación de Ayuda al Niño Quemado (COANIQUEM) due to out patient burn injuries management at the beginning of COVID-19 lockdown with the same period the year before. PATIENTS AND METHODS: Analytical and cross-sectional study. A population of 2,027 patients under the age of 20, who were admitted to COANIQUEM for the first time with burn inju ries, between April and July of 2019 and 2020 was analyzed. The number of patients admitted each month was registered as well as their demographic, social, and clinical characteristics. The monthly percentage variation was calculated by comparing patient data in both years. RESULTS: During 2020, there was a 48.7% decrease in overall outpatient admissions. There was a relative increase of 10.5% in burns in patients under 5 years old, 18.3% in scalds, 33.1% in the number of burns in 3 or more body locations, and 16.8% in burns occurring at home. These parameters were not influenced by geographic location, sex, or socioeconomic level. CONCLUSIONS: In the first period of the COVID-19 pandemic, with strict lockdown strategies, there was a decrease in the demand for burn care, affecting both outpatients with acute burns and those who were admitted for sequelae rehabilitation, as a result of the effective decrease in the burns incidence and the reduced access to health care.


Assuntos
Queimaduras , COVID-19 , Adolescente , Distribuição por Idade , Queimaduras/epidemiologia , Queimaduras/etiologia , Queimaduras/terapia , COVID-19/epidemiologia , COVID-19/prevenção & controle , Criança , Pré-Escolar , Chile/epidemiologia , Controle de Doenças Transmissíveis , Estudos Transversais , Atenção à Saúde , Humanos , Pacientes Ambulatoriais , Pandemias/prevenção & controle
3.
Fish Physiol Biochem ; 46(1): 23-37, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31401709

RESUMO

Determination of the main nutritional requirements at different developmental stages is a prerequisite in the formulation of feeds for newly cultured fish species. In the present study, the lipid and protein requirements of larvae of a native Mexican fish, the three-spot cichlid Cichlasoma trimaculatum, were assessed using a two-factor experimental design that considered four protein (35, 40, 45, and 50%) and two lipid levels (16 and 22%) on growth, survival, and digestive enzyme activities. The best growth and feed efficiency results were obtained when larvae were fed diets including 45% protein and 22% lipids. Comprehensive evaluation of the profile of digestive enzymes using multivariate analysis also demonstrated significant differences in nutritional condition generated by varying inclusion of nutrients. Thus, an increase in protein led to an increase in alkaline protease activity and a reduction in leucine aminopeptidase activity, and the reduction of dietary lipid content led to a significant increase in lipase and trypsin enzymatic activities. Based on our results, C. trimaculatum larvae have a high capacity to hydrolyze both nutrients (protein and lipids) for the high digestive enzyme activities and increase their growth, particularly with a diet containing 45% protein and 22% lipids.


Assuntos
Ciclídeos/fisiologia , Dieta , Gorduras na Dieta , Proteínas Alimentares , Animais , Ciclídeos/metabolismo , Lipase , Lipídeos , Proteínas , Tripsina
4.
Rev Chil Pediatr ; 89(4): 477-483, 2018 Aug.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-30571821

RESUMO

INTRODUCTION: Duchenne muscular dystrophy (DMD) leads to a progressive deterioration of the mus cle function and premature death. There are no longitudinal studies on the course of this pathology in Chile. OBJECTIVE: To determine survival between the years 1993-2013, divided into two periods (1993-2002 and 2003-2013), and the effect of social determinants in patients with DMD admitted in Teleton Institutes of Chile (TI). PATIENTS AND METHOD: Prospective follow-up study in a clinical series of 462 patients with DMD. The information was obtained by searching for patients with DMD in OLAP cube (Online Analytical Processing). From the clinical records of the TI of Santiago, the variables corresponding to the diagnostic method, stage of DMD described in terms of muscle de terioration and function according to Swinyard classification were recorded; existence and type of tests that conclude the diagnosis and, in the cases reported, the existence of family history. Kaplan Meier survival analysis was applied, where global survival was defined between birth and age of death. The determinant factors analyzed were estimated through the Cox-Snell's proportional risk model. RESULTS: Survival at 20 years of age from TI entry was 51.7% (CI95%: 45.1-57.8), 48.5% in the period 1993-2002 and 72.8% between 2003-2013. The percentage of survival at the same age according to socioeconomic status (SES) was 82% in high SES, 67% in middle SES, and 42% in low SES, with a statistically significant difference between high and middle SES in relation to extreme poverty. Ac cording to country areas, the survival was close to 75 % at 17 years of age. CONCLUSIONS: The survival information from patients with DMD from childhood to adult life is valuable for predicting the clinical course of the disease with the current medical care. There is evidence of improvement in the probability of survival at the age of 20 and marked inequity according to the socioeconomic variable.


Assuntos
Distrofia Muscular de Duchenne/mortalidade , Adolescente , Adulto , Criança , Chile/epidemiologia , Feminino , Seguimentos , Humanos , Estimativa de Kaplan-Meier , Masculino , Prognóstico , Modelos de Riscos Proporcionais , Estudos Prospectivos , Adulto Jovem
5.
Rev. chil. pediatr ; 89(4): 477-483, ago. 2018. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-959549

RESUMO

INTRODUCCIÓN: La distrofia muscular de Duchenne (DMD) conduce a un deterioro progresivo de la función muscular y muerte prematura. Los estudios longitudinales sobre el curso de esta patología en Chile, son nulos. OBJETIVO: Determinar sobrevida entre los años 1993-2013, en 2 periodos (1993 2002 y 2003-2013); y efecto de determinantes sociales en pacientes con DMD ingresados a Institutos Teletón Chile (IT). PACIENTES Y MÉTODO: Estudio pronóstico de seguimiento en serie clínica de 462 pacientes portadores de DMD. La información requerida se obtuvo mediante búsqueda de pacientes con DMD en cubo OLAP (On-Line Analytical Processing). De las fichas clínicas del IT-Stgo, se registraron las variables correspondientes al método diagnóstico, etapa de DMD descrito en función al deterioro muscular y funcionamiento mediante Escala Swinyard; existencia y tipo de exámenes que concluyen el diagnóstico y en los casos que se informó, la existencia de antecedentes familiares. Se realizó análisis de sobrevida de Kaplan Meier, donde la sobrevida global se definió entre el nacimiento y edad de muerte. Los factores determinantes analizados fueron estimados a través del modelo de riesgos proporcionales de Cox-Snell. RESULTADOS: La sobrevida a los 20 años de edad desde el ingreso a los IT, fue de 51,7% (IC95%: 45,1-57,8%); en el período 1993-2002 de 48,5% y entre 2003-2013 de 72,8%. El porcentaje de sobrevida a la misma edad, según nivel socioeconómico alto fue de 82%, medio 67% y bajo 42%, diferencia estadísticamente significativa entre nivel alto y medio, respecto de extrema pobreza. Según zonas del país, la sobrevida fue cercana al 75% a los 17 años de edad. CONCLUSIONES: La información de sobrevida aportada en pacientes con DMD desde la infancia hasta la vida adulta, es valiosa para predecir el curso clínico de la enfermedad con la atención médica actual. Se evidencia mejoría en la probabilidad de sobrevida a los 20 años e inequidad pronunciada según variable socioeconómica.


INTRODUCTION: Duchenne muscular dystrophy (DMD) leads to a progressive deterioration of the mus cle function and premature death. There are no longitudinal studies on the course of this pathology in Chile. OBJECTIVE: To determine survival between the years 1993-2013, divided into two periods (1993-2002 and 2003-2013), and the effect of social determinants in patients with DMD admitted in Teleton Institutes of Chile (TI). PATIENTS AND METHOD: Prospective follow-up study in a clinical series of 462 patients with DMD. The information was obtained by searching for patients with DMD in OLAP cube (Online Analytical Processing). From the clinical records of the TI of Santiago, the variables corresponding to the diagnostic method, stage of DMD described in terms of muscle de terioration and function according to Swinyard classification were recorded; existence and type of tests that conclude the diagnosis and, in the cases reported, the existence of family history. Kaplan Meier survival analysis was applied, where global survival was defined between birth and age of death. The determinant factors analyzed were estimated through the Cox-Snell's proportional risk model. RESULTS: Survival at 20 years of age from TI entry was 51.7% (CI95%: 45.1-57.8), 48.5% in the period 1993-2002 and 72.8% between 2003-2013. The percentage of survival at the same age according to socioeconomic status (SES) was 82% in high SES, 67% in middle SES, and 42% in low SES, with a statistically significant difference between high and middle SES in relation to extreme poverty. Ac cording to country areas, the survival was close to 75 % at 17 years of age. CONCLUSIONS: The survival information from patients with DMD from childhood to adult life is valuable for predicting the clinical course of the disease with the current medical care. There is evidence of improvement in the probability of survival at the age of 20 and marked inequity according to the socioeconomic variable.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto , Adulto Jovem , Distrofia Muscular de Duchenne/mortalidade , Prognóstico , Modelos de Riscos Proporcionais , Chile/epidemiologia , Estudos Prospectivos , Seguimentos , Estimativa de Kaplan-Meier
6.
Rehabil. integral (Impr.) ; 12(2): 93-102, dic. 2017. tab
Artigo em Espanhol | LILACS | ID: biblio-882783

RESUMO

The Sensory Motor Performance Quality Scale of babies from 2 to 15 months of age, detected with delayed motor development, or at risk or with cerebral palsy, is presented and its application exemplified through a case corresponding to the sixth month the subscale.


Se presenta la Escala de la Calidad del Desempeño Sensoriomotor de bebés de 2 a 15 meses de edad, detectados con retraso del desarrollo psicomotor, o diagnosticados en riesgo o con parálisis cerebral. Se ejemplifica su aplicación a través de un caso correspondiente a la subescala del sexto mes.


Assuntos
Humanos , Lactente , Desenvolvimento Infantil , Deficiências do Desenvolvimento , Destreza Motora , Testes Neuropsicológicos , Desempenho Psicomotor , Paralisia Cerebral
7.
Rev. chil. pediatr ; 88(6): 730-735, dic. 2017. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-900044

RESUMO

INTRODUCCIÓN: La quemadura en niños por rotura de bolsa de agua caliente, presentó un incremento brusco y significativo alrededor del año 2000 en Chile. Ante ello, la Corporación de Ayuda al Niño Quemado (COANIQUEM) difundió conceptos de prevención en su uso y alerta a autoridades. Posteriormente el Instituto de Normalización Nacional introdujo normativas de certificación de calidad de los productos comercializados en el país. OBJETIVO: Determinar el impacto de medidas preventivas y de certificación de calidad de las bolsas de agua caliente en las quemaduras por rotura del producto en niños. PACIENTES Y MÉTODO: Revisión de ingresos de 795 pacientes menores de 15 años, con quemaduras por rotura de bolsa de agua caliente, entre 2000-2014, en COANIQUEM-Santiago. Se determinó evolución de las frecuencias de quemaduras por el agente etiológico y se comparó el perfil epidemiológico en los períodos quinquenales inicial y final. RESULTADOS: Entre 2000-2004, se registró un incremento de 272,7% en los ingresos y un descenso de 81,3% entre 2005-2014. Las características demográficas, mes de ocurrencia de las quemaduras y necesidad de algún tipo de cirugía, fueron similares en los períodos comparados. El número de localizaciones disminuyó concentrándose en una quemadura (77,8%). En el segundo período incluyó además de extremidad inferior, abdomen y pelvis como ubicaciones frecuentes. CONCLUSIONES: Se verifica un importante descenso de las quemaduras por bolsa de agua caliente en niños, y un cambio significativo en sus características epidemiológicas, coincidiendo con medidas de prevención y normativa de certificación de calidad de los implementos.


INTRODUCTION: Children scalded by the tearing of hot-water bottles presented a sudden and significa tive increase around 2000 in Chile. For this reason the Aid to Burned Children Corporation (COA-NIQUEM) publicized prevention concepts concerning the careful use of this device and raised a voice of alarm to authorities. Later, the National Normalization Institute introduced quality certification standards for hot water bottles sold in the country. OBJECTIVES: Determine the impact of preventive measures and quality certification for hot water bottles in burns caused by tearing of the device on children. PATIENTS AND METHOD: Review of 795 patients under 15 admitted with injuries caused by hot-water bottle rupture between 2000 and 2014 at COANIQUEM Santiago. The frecuency of burns by the ethiological agent is determined and the epidemiological profile are compared in the initial and final quinquenial period. RESULTS: Between 2000-2004, an increase of 272.7% was recorded and then a decrease of 81.3 % was found between 2005-2014. Demographic characteristics, month of occurrence and need of some kind of surgery were similar in both periods. The number of locations and injuries diminished, and are concentrated in one burn (77.8%). In the first period the main anatomical region affected was lower limbs and in the second period abdominal and pelvis are also frequent. CONCLUSIONS: An important decrease of burns by hot-water bottle rupture with significant changes in their epidemiological characteristic is verified. This coincides with preventive measures and manufacturing standards regulations and quality control.


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Queimaduras/prevenção & controle , Queimaduras/epidemiologia , Qualidade de Produtos para o Consumidor/legislação & jurisprudência , Qualidade de Produtos para o Consumidor/normas , Falha de Equipamento , Controle de Qualidade , Queimaduras/etiologia , Água , Chile/epidemiologia , Estudos Retrospectivos
8.
Rev Gastroenterol Mex ; 82(4): 287-295, 2017.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-28389051

RESUMO

INTRODUCTION: Bilioenteric fistulas are the abnormal communication between the bile duct system and the gastrointestinal tract that occurs spontaneously and is a rare complication of an untreated gallstone in the majority of cases. These fistulas can cause diverse clinical consequences and in some cases be life-threatening to the patient. AIM: To identify the incidence of bilioenteric fistula in patients with gallstones, its clinical presentation, diagnosis through imaging study, surgical management, postoperative complications, and follow-up. MATERIALS AND METHODS: A retrospective study was conducted to search for bilioenteric fistula in patients that underwent cholecystectomy at our hospital center due to cholelithiasis, cholecystitis, or cholangitis, within a 3-year time frame. RESULTS: Four patients, 2 men and 2 women, were identified with cholecystoduodenal fistula. Their mean age was 81.5 years. Two of the patients presented with acute cholangitis and 2 presented with bowel obstruction due to gallstone ileus. All the patients underwent surgical treatment and the diagnostic and therapeutic management of each of them was analyzed. CONCLUSIONS: The incidence of cholecystoduodenal fistula was similar to that reported in the medical literature. It is a rare complication of gallstones and its diagnosis is difficult due to its nonspecific symptomatology. It should be contemplated in elderly patients that have a contracted gallbladder with numerous adhesions.


Assuntos
Fístula Biliar/cirurgia , Colecistectomia , Colelitíase/complicações , Fístula Intestinal/cirurgia , Idoso , Idoso de 80 Anos ou mais , Fístula Biliar/diagnóstico , Fístula Biliar/epidemiologia , Fístula Biliar/etiologia , Feminino , Seguimentos , Humanos , Incidência , Fístula Intestinal/diagnóstico , Fístula Intestinal/epidemiologia , Fístula Intestinal/etiologia , Masculino , Estudos Retrospectivos , Resultado do Tratamento
9.
Rev Chil Pediatr ; 88(6): 730-735, 2017 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-29546921

RESUMO

INTRODUCTION: Children scalded by the tearing of hot-water bottles presented a sudden and significa tive increase around 2000 in Chile. For this reason the Aid to Burned Children Corporation (COA-NIQUEM) publicized prevention concepts concerning the careful use of this device and raised a voice of alarm to authorities. Later, the National Normalization Institute introduced quality certification standards for hot water bottles sold in the country. OBJECTIVES: Determine the impact of preventive measures and quality certification for hot water bottles in burns caused by tearing of the device on children. PATIENTS AND METHOD: Review of 795 patients under 15 admitted with injuries caused by hot-water bottle rupture between 2000 and 2014 at COANIQUEM Santiago. The frecuency of burns by the ethiological agent is determined and the epidemiological profile are compared in the initial and final quinquenial period. RESULTS: Between 2000-2004, an increase of 272.7% was recorded and then a decrease of 81.3 % was found between 2005-2014. Demographic characteristics, month of occurrence and need of some kind of surgery were similar in both periods. The number of locations and injuries diminished, and are concentrated in one burn (77.8%). In the first period the main anatomical region affected was lower limbs and in the second period abdominal and pelvis are also frequent. CONCLUSIONS: An important decrease of burns by hot-water bottle rupture with significant changes in their epidemiological characteristic is verified. This coincides with preventive measures and manufacturing standards regulations and quality control.


Assuntos
Queimaduras/epidemiologia , Queimaduras/prevenção & controle , Qualidade de Produtos para o Consumidor , Falha de Equipamento , Adolescente , Queimaduras/etiologia , Criança , Pré-Escolar , Chile/epidemiologia , Qualidade de Produtos para o Consumidor/legislação & jurisprudência , Qualidade de Produtos para o Consumidor/normas , Feminino , Humanos , Lactente , Masculino , Controle de Qualidade , Estudos Retrospectivos , Água
10.
Rev. mex. ing. bioméd ; 37(3): 221-233, Sep.-Dec. 2016. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-961325

RESUMO

Resumen En este trabajo se presenta un algoritmo para estimar el ángulo de rodilla a partir del ángulo de cadera y parámetros de marcha, el cual sólo utiliza un sensor en el muslo para la estimación. Para el desarrollo del algoritmo fue indispensable realizar un análisis de marcha para establecer parámetros de diseño. Se utilizó la correlación natural entre cadera y rodilla para separar los movimientos de flexión-extensión de marcha en dos etapas:1) movimientos donde el pie no está en contacto total con el piso; 2) movimientos de contacto total del pie con el piso. La estimación es para movimientos de marcha, se realiza en tiempo real y la variación de velocidad en la marcha no afecta la estimación del ángulo. Se utilizaron regresores lineales para aproximar el ángulo estimado de rodilla al ángulo real. En todos los casos de estudio de marcha, los resultados mostraron una aproximación aceptable del ángulo de la rodilla; el error promedio de estimación fue de 8.25◦. El principal logro de este trabajo fue desarrollar un algoritmo para dar una posible solución al problema de coordinación entre el cuerpo humano y prótesis transfemorales inteligentes, aun ante cambios de velocidad en la marcha.


Abstract This paper presents an algorithm to estimate the knee angle from hip angle and gait parameters. This algorithm uses a single sensor on the thigh to achieve the estimation. Hip-knee natural correlations were employed in order to analyze the gait flexion-extension movements in two stages: 1) when the foot is not in full contact with the floor (swing phase and heel contact); 2) when the whole sole makes contact with the ground (stance phase). The estimation is developed in real-time for gait movements and speed fluctuations do not distort the angle estimated. In addition, the simple linear regression were used to approximate the estimated angle to actual knee angle. The experimental results obtained from the gait studies, showed an acceptable knee angle approximation; the mean error estimation was 8.25◦. The major goal of this work was the development of an algorithm that can solve the problem of human body-intelligent transfemoral prosthesis coordination, even if there are gait speed fluctuations.

11.
Rehabil. integral (Impr.) ; 11(2): 90-98, dic. 2016. ilus, tab
Artigo em Espanhol | LILACS | ID: biblio-869333

RESUMO

Cerebral palsy (CP) and other diseases cause different levels of dysfunction in the ability to grasp or grip with the hands. Modified and validated Bilan 400 points scale (PBM-400) helps to assess these functions. Objective: To determine the characteristics of hand function in children and young people with neuromotor disabilities according to gender, age, diagnosis and level using functional PBM-400. Patients and Methods: Descriptive and cross-sectional study on 138, 7 to 17 year-old patients with CP (diplegia, hemiparesis), obstetric brachial palsy (OBP) and others; with mild or moderate functional impairment, receiving treatment at Instituto Teletón in Santiago, Chile. Nine trained occupational therapists apply PBM-400 in standardized conditions, assessing hand mobility, grasp and/or movement, functional activities and grip strength with dynamometer, vigorimeter and pinch gauge. Result: 62.5 percent of diplegia patients and 100 percent of the patients with polyneuropathy, showed right laterality. According to functional impairment, right laterality prevails. Grip strength showed the lowest performance in all diagnoses, whereas in cases with prevalence of right-hand laterality it was functional activities. Significant differences in hand functionality were recorded depending on diagnosis and functional impairment, regardless of laterality. Age and gender do not affected hand functionality in the overall of children with various diagnoses. Conclusions: The modified Bilan 400 points scale helps to distinguish hand function depending on laterality, diagnose and functional impairment, becoming a generic scale for therapeutic decision making.


Introducción: La parálisis cerebral (PC) y otras patologías, implican diversos grados de disfunción en la ejecución de alcances y prensiones de las manos. La pauta Bilan 400 points modificada y validada (PBM-400), permite evaluar esas funciones. Objetivo: Determinar las características de la función manual en niños y jóvenes con discapacidad neuromotora según sexo, edad, diagnóstico y compromiso funcional, mediante PBM-400. Pacientes y Método: Estudio descriptivo, transversal en 138 pacientes de 7 a 17 años de edad, con PC (diplejía, hemiparesia) parálisis braquial obstétrica (PBO) y otros; con compromiso funcional leve o moderado, atendidos en el Instituto Teletón Santiago-Chile. Nueve terapeutas ocupacionales entrenados, aplican PBM-400 en condiciones estandarizadas, evaluando movilidad manual, prensión y/o desplazamiento, actividades funcionales y fuerza prensora con dinamómetro, vigorímetro y pinzómetro. Resultados: El 62,5 por ciento de los pacientes con diplejía y el 100 por ciento de los pacientes con polineuropatías, registran lateralidad derecha. Según compromiso funcional, predomina lateralidad derecha. La dimensión de menor rendimiento fue fuerza prensora para todos los diagnósticos y en los casos con predominio de lateralidad manual derecha, fue la dimensión de actividades funcionales. Se registraron diferencias significativas de funcionalidad de mano según diagnóstico y compromiso funcional, independiente de lateralidad. La edad y sexo no influyen en funcionalidad manual en el conjunto de niños con diversos diagnósticos. Conclusiones: La pauta Bilan 400 puntos modificada, logra discriminar significativamente la funcionalidad manual según lateralidad, diagnóstico y compromiso funcional, constituyéndose en una escala genérica para la toma de decisiones terapéuticas.


Assuntos
Humanos , Masculino , Adolescente , Feminino , Criança , Avaliação da Deficiência , Força da Mão/fisiologia , Paralisia Cerebral/fisiopatologia , Estudos Transversais
12.
Rehabil. integral (Impr.) ; 10(2): 83-90, dic.2015. tab
Artigo em Espanhol | LILACS | ID: lil-784611

RESUMO

Duchenne muscular dystrophy (DMD) in their natural evolution leads to loss of ambulation between 7 and 13 years of age and death in adolescence close to 20 years. The estimated global incidence is of 1/3,500 male births; data in Chile is unknown. Objective: To estimate the incidence, prevalence of DMD and to describe clinical and sociodemographic characteristics of patients admitted to Teletón-Chile between 1993 and 2013. Patients and Method: A descriptive, retrospective, longitudinal study with review of medical records and database at Teletón. 462 DMD patients were admitted during the study period. Results: The incidence and prevalence in Teletón was of 1/6,558 male live births and the prevalence of 11.51 [CI 10.46 to 12.56] 105 men < 30 years. The average age of first consultation was 6.7 +/- 3.4 years, with mild or moderate functional level (65.6 percent). At the end of the study 67 percent were wheelchair users, with medical prescription at 10.8 +/- 3.3 years. 52.2 percent of patients were classified as extreme poverty, attended at Teletón centers of the central region (55.2 percent), and current average age of 14.7 +/- 5.7 years. 35.9 percent of DMD patients were dead at an average age of 18.1 +/- 3.5 years. Conclusion: The incidence and prevalence rates of DMD live births for males < 30 years admitted to Teletón, have declined between 1993-2011; as well as the average age of first consultation. The loss of ambulation and the average age of death are comparable with the current literature...


La distrofia muscular de Duchenne (DMD) en su evolución natural, produce pérdida de deambulación entre los 7 y 13 años de edad y la muerte en la adolescencia cercana a los 20 años. La incidencia mundial se estima de 1/3.500 nacimientos masculinos; en Chile se desconoce su magnitud. Objetivo: Estimar tasas de incidencia, prevalencia de DMD y describir características clínicas y sociodemográficas de pacientes ingresados a Institutos Teletón-Chile (IT) entre 1993 y 2013. Pacientes y Método: Estudio descriptivo, retrospectivo, longitudinal, con revisión de fichas clínicas y base de datos de IT. Se identificaron 462 pacientes con DMD, ingresados en el período estudiado. Resultados: La tasa de incidencia en IT fue de 1/6.558 nacidos vivos masculinos y prevalencia de 11,51 [IC: 10,46-12,56] por 105 varones < 30 años. Edad media de primera consulta: 6,7 +/- 3,4 años, con compromiso funcional leve o moderado (65,6 por ciento); al término del estudio el 67 por ciento eran usuarios de silla de ruedas, con prescripción médica a los 10,8 +/- 3,3 años. 52,2 por ciento de los pacientes de extrema pobreza, atendidos en IT zona central del país (55,2 por ciento), edad promedio actual de 14,7 +/- 5,7 años. El 35,9 por ciento estaban fallecidos, a la edad promedio de 18,1 +/- 3,5 años. Conclusión: Las tasas de incidencia y prevalencia de DMD para los nacidos vivos varones < 30 años ingresados a los IT, han disminuido entre 1993-2011; también la edad promedio de primera consulta. La pérdida de la marcha y la edad media de la defunción, son comparables con la literatura...


Assuntos
Humanos , Masculino , Adolescente , Adulto , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adulto Jovem , Distrofia Muscular de Duchenne/epidemiologia , Chile/epidemiologia , Distrofias Musculares/epidemiologia , Epidemiologia Descritiva , Incidência , Prevalência , Estudos Retrospectivos , Fatores Socioeconômicos
14.
Rev Chil Pediatr ; 86(4): 251-6, 2015.
Artigo em Espanhol | MEDLINE | ID: mdl-26298301

RESUMO

INTRODUCTION: Self-concept is the set of ideas and attitudes that a person has about him/herself. OBJECTIVE: To evaluate whether there are differences in the level of self-concept in children 8-12 years old with and without burns sequelae. To identify predictive variables of self-concept in children with sequelae. PATIENTS AND METHOD: A comparative cross-sectional study of self-concept in 109 children with burns sequelae, from 8 to 12 years old, with 109 children without burns sequelae, and of the same age and socioeconomic status. The Piers-Harris self-concept scale is used, which provides a general measurement of self-concept and behavioural, intellectual and school status, appearance, and physical attributes, anxiety, popularity, happiness and satisfaction dimensions. RESULTS: There were no significant differences in the level of general self-concept or their dimensions (P>.05). In the group with burns sequelae, the protective factor was the variable number of sequels was associated with the dimensions of anxiety, popularity, happiness-satisfaction and general self-concept. The location variable emerged as a risk factor for the behavioural dimension. DISCUSSION: The absence of differences in self-concept between children with burns sequelae and children without them is similar to that reported in the literature. The finding in the risk and protective factors encourages to further research, and perhaps incorporating pre-morbidity and family background.


Assuntos
Queimaduras/psicologia , Autoimagem , Estudos de Casos e Controles , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Fatores de Proteção , Fatores de Risco
15.
Rev. chil. pediatr ; 86(4): 251-256, ago. 2015. tab
Artigo em Espanhol | LILACS | ID: lil-764081

RESUMO

Introducción: Autoconcepto es el conjunto de ideas y actitudes que se tiene acerca de sí mismo. Nuestro objetivo fue evaluar si existen diferencias en el nivel de autoconcepto de niños de 8-12 años con y sin secuelas de quemaduras, e identificar variables predictoras del autoconcepto en los niños con secuelas. Pacientes y método: Estudio comparativo, transversal de 109 niños con secuelas de quemaduras de 8 a 12 años de edad, con 109 niños sin secuelas de quemaduras, del mismo grupo de edad y nivel socioeconómico. Se utilizó la escala de autoconcepto de Piers-Harris, que entrega medida de autoconcepto general y dimensiones: conductual, estatus intelectual y escolar, apariencia y atributos físicos, ansiedad, popularidad, felicidad y satisfacción. Resultados: No hubo diferencias significativas en el nivel de autoconcepto general ni en sus dimensiones al comparar ambos grupos (p > 0,05). Dentro del grupo con secuelas de quemaduras la variable número de secuelas resultó ser un factor protector para las dimensiones ansiedad, popularidad, felicidad-satisfacción y autoconcepto general. La variable localización surgió como factor de riesgo para la dimensión conductual. Discusión: La ausencia de diferencias en autoconcepto entre niños con secuelas de quemaduras y sin ellas es similar a lo reportado por la literatura. El hallazgo en factores de riesgo y protectores motiva a continuar investigando, incorporando antecedentes premórbidos y familiares.


Introduction: Self-concept is the set of ideas and attitudes that a person has about him/herself. Objective: To evaluate whether there are differences in the level of self-concept in children 8-12 years old with and without burns sequelae. To identify predictive variables of self-concept in children with sequelae. Patients and method: A comparative cross-sectional study of self-concept in 109 children with burns sequelae, from 8 to 12 years old, with 109 children without burns sequelae, and of the same age and socioeconomic status. The Piers-Harris self-concept scale is used, which provides a general measurement of self-concept and behavioural, intellectual and school status, appearance, and physical attributes, anxiety, popularity, happiness and satisfaction dimensions. Results: There were no significant differences in the level of general self-concept or their dimensions (P > .05). In the group with burns sequelae, the protective factor was the variable number of sequels was associated with the dimensions of anxiety, popularity, happiness-satisfaction and general self-concept. The location variable emerged as a risk factor for the behavioural dimension. Discussion: The absence of differences in self-concept between children with burns sequelae and children without them is similar to that reported in the literature. The finding in the risk and protective factors encourages to further research, and perhaps incorporating pre-morbidity and family background.


Assuntos
Humanos , DNA , Compostos de Amônio Quaternário/química , Serina/química , Tensoativos/química , Amidas/química , Aminas/química , Linhagem Celular Tumoral , Química Farmacêutica/métodos , Ésteres/química , Técnicas de Transferência de Genes , Terapia Genética/métodos , Células HeLa , Lipídeos/química , Transfecção/métodos
16.
Rehabil. integral (Impr.) ; 10(1): 8-16, jul. 2015. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-774861

RESUMO

Introducción: El dolor fantasma es una condición frecuente en pacientes amputados lo que genera discapacidad importante. En población adulta se estima una prevalencia entre 49-82 por ciento. Existe escasa evidencia de la incidencia y prevalencia en población de niños y adolescentes. Objetivos: Estimar la incidencia y la prevalencia del dolor fantasma en la población de amputados adquiridos del Instituto Teletón (IT) de Santiago de 10 años y más; caracterizar a esta población y asociar distintos factores clínicos y demográficos con la presencia de este dolor. Pacientes y Métodos: Estudio descriptivo de incidencia y prevalencia basado en la revisión de fichas clínicas para la obtención de datos demográficos, clínicos y evaluación de registro de dolor fantasma. Se aplicó encuesta telefónica a pacientes de 10 años o más, con diagnóstico de una o más amputación/es adquirida/s, que se atiendan o hayan sido atendido en IT Santiago hasta el año 2013. Resultados: La incidencia de dolor fantasma en la población estudiada es de 11 por 100 personas/año y prevalencia de 62 por ciento. Se encontraron asociaciones estadísticamente significativas, entre la presencia de dolor fantasma y el tiempo transcurrido desde la amputación (a mayor tiempo transcurrido, menor dolor) y edad de la amputación (a mayor edad en que se realizó la amputación mayor dolor). Conclusión: El dolor fantasma es un fenómeno frecuente en pacientes amputados adquiridos de 10 años y más atendidos en el IT de Santiago con una prevalencia del 62 por ciento.


Introduction: Phantom pain is a common condition in amputated patients generating significant disability. Prevalence among adult population is estimated at 49-82 percent. There is little evidence of the incidence and prevalence in child and adolescent population. Objectives: To estimate the incidence and prevalence of phantom pain in amputees aged 10 years and older of the Telethon Institute of Santiago; characterize this population and associate different clinical and demographic factors with the presence of phantom pain. Patients and Methods: Study incidence and prevalence based on a review of medical records to obtain demographic and clinical data. In addition a telephone survey was made to patients 10 years or older diagnosed with one or more acquired amputations who are treated or have been treated at Telethon Institute of Santiago until 2013. Results: The incidence of phantom pain in the study population is 11 per 100 persons/year and prevalence is 62 percent. Statistically significant associations were found between the presence of phantom pain variables and time since amputation (the longer the time elapsed, less pain) and age of amputation (the older the age at which major amputation was performed more pain). Conclusion: Phantom pain is a common phenomenon in patients with acquired amputation aged 10 years and older treated at the Telethon Institute of Santiago prevalence being 62 percent.


Assuntos
Humanos , Masculino , Adolescente , Adulto , Feminino , Criança , Adulto Jovem , Amputação Traumática , Membro Fantasma/epidemiologia , Chile , Prevalência , Estudos Retrospectivos
17.
Fish Physiol Biochem ; 41(1): 267-79, 2015 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-25547606

RESUMO

A study was performed in order to understand the development of digestive enzymes during initial ontogeny of Cichlasoma trimaculatum, for which the activity of acidic and alkaline proteases, lipases, amylases and phosphatases was determined by means of biochemical and electrophoretic analysis. Our results showed that the activity of alkaline proteases, trypsin and chymotrypsin is present from day 6 after hatching (dah) during exogenous feeding with Artemia nauplii. The activities of carboxypeptidase A and leucine aminopeptidase are present from the first days, increasing at 6 dah and reaching their maximum activity at 9 dah while acid protease activity started at 9 dah. Furthermore, the lipase activity is detected on 6 dah and keeps increasing and decreasing on 17 dah. Amylase activity is detected on 3 dah, presenting fluctuations until 45 dah, where it reaches its maximum activity. Acid and alkaline phosphatases are detected from 3 dah and reach a maximum activity between 13 and 19 dah. The SDS-PAGE electrophoresis revealed six types of bands in the alkaline proteases, with molecular weight between 113.4 and 20.4 kDa. First three bands appear on 6 dah, but it is until 11 dah when all isoforms appear. Based on these results, it is considered that this species completes its digestive enzymatic machinery from day 9 after hatching, therefore is recommended to perform the transition from live feed to inert feed at 15 dah.


Assuntos
Aquicultura/métodos , Ciclídeos/crescimento & desenvolvimento , Sistema Digestório/enzimologia , Regulação da Expressão Gênica no Desenvolvimento/fisiologia , Regulação Enzimológica da Expressão Gênica/fisiologia , Fatores Etários , Amilases/metabolismo , Animais , Carboxipeptidases A/metabolismo , Quimotripsina/metabolismo , Ciclídeos/metabolismo , Sistema Digestório/crescimento & desenvolvimento , Eletroforese em Gel de Poliacrilamida , Leucil Aminopeptidase/metabolismo , Lipase/metabolismo , Peptídeo Hidrolases/metabolismo , Tripsina/metabolismo
18.
Rev. chil. pediatr ; 85(6): 674-681, dic. 2014. tab
Artigo em Espanhol | LILACS | ID: lil-734808

RESUMO

Objective: To estimate the incidence of burn injuries in 2011 and prevalence in population < 20 years old in three districts of Chile's Metropolitan Region. Patients and Method: A Prevalence census study of 4,968 households in the mentioned areas. Probability, representative, and two-stage cluster sampling, with sampling error < 5%, was applied. Complex sample modules were used to analyze data using SPSS 17.0. The census was conducted in the site, asking in each selected household those 18 and older, about household composition by gender and age to identify those < 20 years with burns that occurred sometime in their life or in 2011. Results: A burn incidence of 2.02% [95% CI: 1.63-2.61%] and a prevalence of 13.50% [95% CI: 11.8815.31%] were obtained. The highest incidence was reported in female patients (2.31%) [95% CI: 1.77- 2.99%]. In males < 5 years of age, the incidence was 2.76% [95% CI: 1.42-5.28%] and in females, it was 2.46% [95% CI: 1.37-4.36%]. The municipality of Lo Prado had the highest incidence (2.73%) [95% CI: 1.82-4.07%]; Pudahuel recorded the highest prevalence (14.01%) [95% CI: 11.87-16.46%]. Conclusion: In 20 years, the incidence of burns in patients < 15 years of age fell by 46.4%. On average in the communities studied, 1 in 7 children/adolescent has suffered burns between birth and the time of his 20th birthday.


Objetivo: Estimar incidencia de lesiones por quemaduras en año 2011 y prevalencia en población < 20 años, en tres comunas de la Región Metropolitana de Chile. Pacientes y Método: Estudio de prevalencia con empadronamiento de 4.968 hogares de comunas mencionadas. Se aplicó muestra probabilística, representativa, bietápica y de conglomerados, con error muestral < 5%. Se usó módulo de muestras complejas para procesar datos con SPSS 17.0. El empadronamiento se realizó en terreno, preguntando en cada vivienda seleccionada a personas de 18 años y más, sobre composición del hogar por género y edad para identificar < 20 años con quemaduras, ocurridas alguna vez en su vida o en el año 2011. Resultados: Se obtuvo una incidencia de quemaduras de 2,02% [IC95%:1,63-2,61%] y prevalencia de 13,50% [IC95%:11,88-15,31%]. La mayor incidencia fue en mujeres (2,31%) [IC95%:1,77-2,99%]. En varones < 5 años, la incidencia fue de 2,76% [IC95%:1,42-5,28%] y en mujeres de 2,46% [IC95%:1,37-4,36%]. La comuna de Lo Prado tuvo mayor incidencia (2,73%) [IC95%:1,82-4,07%]; Pudahuel registró prevalencia mayor (14,01%) [IC95%:11,87-16,46%]. Conclusión: En 20 años, la incidencia de quemaduras en < 15 años, descendió un 46,4%; en promedio, 1 de cada 7 niños/jóvenes se ha quemado entre el nacimiento y el momento de cumplir 20 años en comunas estudiadas.


Assuntos
Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Adulto Jovem , Queimaduras/epidemiologia , Distribuição por Idade , Chile/epidemiologia , Incidência , Prevalência , Distribuição por Sexo
19.
Rev. chil. pediatr ; 85(6): 690-700, dic. 2014. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-734810

RESUMO

Objective: To determine demographic, clinical and health care factors associated to prevalence of burns in children less than 20 years of age in the districts of Cerro Navia, Lo Prado and Pudahuel, and their comparison with incidence in 2011. Patients and Method: Population survey based on probability and two-stage stratified complex sample of households, registering 4,968 households. In 302 of them randomly selected, the mother/adult present at the time of the injury took a survey. A questionnaire of 50 questions (20 minutes), created by 6 experts and previously validated, was conducted by 10 interviewers and 3 supervisors. People were contacted by telephone before visiting them at their homes. The non-response rate was 6%, after up to 3 home visits. Results: Regarding prevalence, the male-to-female ratio was 1.16:1. Main reasons were hot objects (42.4%) and liquids (41.5%). 84.1% of burns occurred inside the home and in the afternoon (50.7%). 93.3% of the burns took place with an adult present. Hands were the most affected areas (46.7%). 30.2% were left with scars the first time of the accident. 34.4% of the burn victims did not require health care and 8.4% of them required hospitalizations. Over 60% of respondents reported that they poured cold water on the burn as a first step. Conclusion: Relevant information was obtained to be used in burn prevention in children and adolescents. Recall bias is the main limitation of the study.


Objetivo: Determinar factores demográficos, clínicos y de atención de salud asociados a prevalencia de quemaduras en menores de 20 años residentes en comunas de Cerro Navia, Lo Prado y Pudahuel y su comparación con incidencia en 2011. Pacientes y Método: Encuesta poblacional, basada en muestra probabilística, estratificada y bietápica de hogares de tipo compleja, empadronándose 4.968 hogares. En 302 seleccionados aleatoriamente, se aplicó encuesta a madre/adulto presente en el momento de la lesión del menor. Cuestionario de 50 preguntas (20 min), realizado por 6 expertos, y validado previamente, fue aplicado por 10 encuestadores y 3 supervisores. Se contactó telefónicamente las personas antes de concurrir al domicilio. La tasa de no respuesta fue de 6%, luego de realizar hasta 3 visitas al domicilio. Resultados: En prevalencia, la razón masculina sobre femenina fue de 1,16:1. Agentes principales fueron objetos calientes (42,4%) y líquidos calientes (41,5%); 84,1% de las quemaduras ocurrieron dentro del hogar y a media tarde (50,7%); 93,3% de las quemaduras fue con adulto presente. La mano fue la localización más afectada (46,7%); 30,2% quedó con cicatriz la primera vez que se quemó. 34,4% de los quemados no demandó atención de salud y se declararon 8,4% de hospitalizaciones. Más de 60% de los encuestados relató echar agua fría a la quemadura como primera medida. Conclusión: Se obtiene información relevante para utilizar en prevención de quemaduras en niños y jóvenes. El sesgo de recuerdo es la limitante principal del estudio.


Assuntos
Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Adulto Jovem , Queimaduras/epidemiologia , Cicatriz/epidemiologia , Hospitalização/estatística & dados numéricos , Chile/epidemiologia , Cicatriz/etiologia , Incidência , Prevalência , Distribuição por Sexo , Inquéritos e Questionários
20.
Rehabil. integral (Impr.) ; 9(1): 35-43, jul. 2014. tab, ilus
Artigo em Espanhol | LILACS | ID: lil-774859

RESUMO

Introducción: el integro laboral es una meta primordial en la rehabilitación; en pacientes amputados fluctúa entre 43 y 89 por ciento. Existen factores descritos que se asocian a empleabilidad como género, edad a la que fueron amputados, nivel educacional, uso de prótesis, dolor, nivel de amputación y número de extremidades comprometidas. No se han encontrados estudios en pacientes amputados en edad pediátrica ni con amputaciones congénitas. Objetivo: determinar la magnitud de inserción laboral de los pacientes con deficiencias congénitas o amputaciones adquiridas antes de los 18 años, que en el año 2013 tengan entre 25 y 65 años, y analizarla según factores demográficos y clínicos. Método: estudio descriptivo que analizó las variables mencionadas mediante una encuesta telefónica diseñada y validada con este objetivo. La población estudiada correspondió a pacientes con amputaciones de Teletón Santiago, actualmente entre 25-65 años de edad, que residieran en la Región Metropolitana durante su período de rehabilitación. Se excluyó a pacientes con amputaciones parciales de mano o pie, y con compromiso cognitivo. Resultados: se incluyeron 61 pacientes. Todos habían trabajado en algún momento de su vida, y un 86,9 por ciento lo hacía al momento de la encuesta. El 67,3 por ciento tuvo acceso a educación superior. El 81,1 por ciento tenía empleo a tiempo completo. Un 22,6 por ciento deseaba realizar alguna modificación al trabajo actual. Sólo se encontró asociación estadísticamente significativa entre edad y el tipo de empleo. Conclusión: la mayoría de los entrevistados tenían empleo y un alto nivel educacional. Estos pacientes se beneficiarían de estrategias sociales de apoyo a nivel nacional.


Background: job reintegration is a major goal in rehabilitation. In amputees it varies from 43-89 percent. Factors related to employment rate are gender, age at the time of amputation, education, prosthetic use, pain, level of amputation and number of limbs compromised. No specific pediatric studies where found. Objective: to measure employment in patients between 25 and 65 years old with limb deficiencies or amputation before the age of 18 years, and describe it according to clinical and demographic factors. Methods: the following descriptive study measured clinical factors, employment status and characteristics of pediatric amputees thought a phone-survey designed and validated for this purpose. Patients were amputees from Teletón Santiago, living in the metropolitan zone during rehabilitation, aged between 25-65 years. Those with partial hand or foot amputations or with cognitive impairment where excluded. Results: sixty-one patients where included. All of them had worked, and 86.9 percent had a job at the time of the survey. 67 percent had access to higher education. Of them, 81.1 percent had a full time job. Only 22.6 percent wanted job adjustments. Differences were only found between age and employment type. Conclusion: the majority of the amputees interviewed were successfully employed and had a high educational level. These patients may benefit from national support strategies.


Assuntos
Humanos , Masculino , Adulto , Feminino , Pessoa de Meia-Idade , Amputação Traumática/reabilitação , Retorno ao Trabalho , Ajustamento Social , Chile , Emprego , Prevalência , Fatores Socioeconômicos
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