RESUMO
UNLABELLED: We evaluated gonadal function in twenty prepubertal boys (6.87 +/- 3.84 years old) at diagnosis and 2.5 +/- 1.6 years after treatment for acute lymphoblastic leukaemia (ALL). We measured serum levels of inhibin B (RIA method), testosterone, FSH, LH (immunoenzymatic methods) and compared the results with controls (31 healthy boys in prepubertal stage). RESULTS: Serum inhibin B levels were lower at diagnosis (55.81 ng/ml +/- 33.74), comparing to respective values in the controls (105.89 ng/ml +/- 46.64), p<0.0002. The values of inhibin B slightly augmented after 2.5 +/- 1.6 years from chemotherapy (79.47 ng/ml +/- 47.39), p<0.06 but remained lower than those in the controls (p<0.07). We did not find any differences in FSH, LH or testosterone values, before and after chemotherapy, comparing to respective values in the controls. In conclusion, haematological malignancy and its treatment influence gonadal function before puberty with a possibility of recovery. During this period, inhibin B could be used as a sensitive indicator of testicular function.
Assuntos
Antineoplásicos/uso terapêutico , Hormônio Foliculoestimulante/sangue , Inibinas/sangue , Hormônio Luteinizante/sangue , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Antineoplásicos/farmacologia , Criança , Pré-Escolar , Humanos , Masculino , Estadiamento de Neoplasias , Valores de ReferênciaRESUMO
Chosen constitutional and family environment conditions were analysed with diagnosed food allergy as factors predisposing to the process of pathogenic development.
Assuntos
Hipersensibilidade Alimentar/etiologia , Pré-Escolar , Feminino , Humanos , Lactente , Fenômenos Fisiológicos da Nutrição do Lactente , Recém-Nascido , MasculinoRESUMO
Among children treated at the haematological Outpatient Clinic of the Children's Teaching Hospital in Bialystok, 5.6% showed an haematological changes in the blood, caused probably by allergy.
Assuntos
Hipersensibilidade Alimentar/complicações , Doenças Hematológicas/imunologia , Adolescente , Anemia/etiologia , Criança , Pré-Escolar , Feminino , Hipersensibilidade Alimentar/sangue , Humanos , Lactente , MasculinoRESUMO
The frequency of erythrocyturia in children with diagnosed food allergy was evaluated. The analysed clinical and immunological allergic process indicators and one year's observation confirm the allergic background of erythrocyturia in 2.6% of the examined group. There are indications for an elimination diet and the application of anti-allergic treatment in the above cases.