RESUMO
A 14-year-old girl with HIV infection and subcutaneous Kaposi's sarcoma (KS) received thalidomide therapy for oral ulcers, resulting in regression of KS lesions, disappearance of KS-associated herpesvirus (KSHV) DNA from blood, and reduced viral load in tumor tissue. Administration of grauntocyte colony-stimulating factor resulted in clinical exacerbation of KS and reappearance of KSHV DNA in blood.
Assuntos
Infecções por HIV/imunologia , Herpesvirus Humano 8/isolamento & purificação , Imunossupressores/uso terapêutico , Sarcoma de Kaposi/tratamento farmacológico , Talidomida/uso terapêutico , Adolescente , DNA Viral/sangue , Feminino , Fator Estimulador de Colônias de Granulócitos/uso terapêutico , Infecções por HIV/complicações , Infecções por HIV/congênito , Humanos , Indução de Remissão , Sarcoma de Kaposi/etiologia , Sarcoma de Kaposi/imunologia , Carga ViralRESUMO
Pain relief and resolution of oral and perianal ulceration after treatment with thalidomide in a 14 year old girl with vertically acquired HIV infection is reported.
Assuntos
Fissura Anal/tratamento farmacológico , Infecções por HIV/complicações , Imunossupressores/uso terapêutico , Estomatite Aftosa/tratamento farmacológico , Talidomida/uso terapêutico , Adolescente , Feminino , Fissura Anal/virologia , Humanos , Estomatite Aftosa/virologiaRESUMO
This is a case report of an intraorbital tumour found soon after delivery in otherwise normal girl. The clinical manifestation were so intensive that the operation was performed within 24 hours after birth. Histologically a benign teratoma presenting almost all possible tissues was diagnosed. In the follow up the girl's bilateral eye-function was satisfactory and she was doing well.
