[Use of WOBE-MUGOS E for prevention and correction of experimental doxorubicin side-effects]. / Ispol'zovanie VOBE-MUGOS E dlia profilaktiki i korrektsii pobochnykh reaktsii doksorubitsina gidrokhlorida v éksperimente.

Examined in treating rats with Guerin's carcinoma with doxorubicin was the possibility that the polyenzymic drug preparation wobe-mugos E had hepatoprotective, cardioprotective and myeloprotective effects. In intramuscular administration wobe-mugos E has not been found to stimulate the tumour growth, it exhibited a manifest hepatoprotective and myeloprotective actions with respect to adverse reactions of doxorubicin but failed to diminish cardiotoxicity of the latter. The protective effect of the above polyenzymic drug was of a dose-dependent character.

[Influence of tumor drug resistance phenotype on the dynamics of cisplatin-induced changes of rat peripheral lymphocyte chromatin structure in Guerin's carcinoma]. / Vliianie fenotipa lekarstvennoi rezistentnosti opukholi na dinamiku indutsirovann'ikh tsisplatinom izmenenii struktur'i khromatina interfazn'ikh iader limfotsitov perifericheskoi krovi kr'is s kartsinomoi gerena.

The correlation between the tumor drug sensitivity and the degree of lymphocyte interphase nuclei chromatin damages induced by cisplatin in rats was found using sensitive and resistant to cisplatin variants of Guerin's carcinoma. Increased optical density of lymphocyte chromatin in first minutes after cisplatin injection both in rats without Guerin's carcinoma and with sensitive to cisplatin variants of this tumor was observed. Lymphocyte chromatin structure remains unchanged in rats with cisplatin resistant carcinoma. Normal blood cells are suppose to change their sensitiveness to cisplatin under the humoral influence of the growing tumor in according with its phenotype.

[Pharmacokinetics of cisplatin in patients with small cell cancer of the lung]. / Farmakokinetika platina u bol'nykh melkokletochnym rakom legkogo.

Individual pattern of pharmacokinetics of an antitumor drug platin was investigated in patients with lung cancer. Pharmacokinetic parameters varied considerably with patient, directly influencing the drug efficacy.

[Application of synergetics to the theory of ontogenesis (on the parametric control of development)]. / Prilozheniia sinergetiki k ontogenezu (o parametricheskom upravlenii razvitiem).

Applications of synergetics to ontogenesis are discussed. In terms of synergetics, the choice between the concepts of power and parametric control and the description of parameters and dynamic variables of ontogenesis are among the main tasks of the theory of ontogenesis. Examples are provided for multipotency and variability which suggest the parametric control of development. A suggestion is put forward concerning the parameterizing role of directive inductors. Possible ways of overcoming the ambiguity inherent in the parametric control are considered. A general scheme of the ontogenesis control is proposed within the framework of which different types of parameters and dynamic variables are characterized. The concept of chaos is discussed with reference to ontogenesis.

[Effect of hemodialysis on digoxin pharmacokinetics in heart failure in patients with chronic kidney failure]. / Vliianie gemodializa na farmakokinetiku digoksina pri serdechnoi nedostatochnosti u bol'nykh s khronicheskoi pochechnoi nedostatochnost'iu.

The authors have estimated the effect of hemodialysis on the pharmacokinetics of digoxin instilled intravenously to patients with the terminal stage of chronic renal insufficiency. It has been shown that dialysis was associated with an almost double increase in the clearance constant of digoxin due to its additional elimination through the membrane of the dialyzer. Over five h of dialysis the body excretes 12.5% of the administered dose of digoxin which is only 3.8% more (by 19 micrograms) than the average amount eliminated without dialysis. The contribution of dialysis to the elimination of digoxin is insignificant and, therefore, the regimen of its administration on days when dialysis is performed should be left unchanged.

[Pharmacokinetics of penicillins following combined administration with sulfanilamides]. / Farmakokinetika penitsillinov pri kombinirovannom primenenii s sul'fanilamidami.

Combined use of benzylpenicillin or ampicillin with sulfalen or sulfadimethoxine resulted in a decreased binding of the antibiotics to the blood serum proteins and slower elimination of penicillins from the experimental rabbits. It is quite possible that the decreased levels of the antibiotic binding to the proteins caused their slower elimination rates, which was realized by increasing the volume of the drug distribution mainly at the expense of the peripheral compartment and decreased excretion with the urine.