[Iodoantipyrine--an agent for treating and preventing tick-borne encephalitis]. / Iodantipirin--sredstvo dlia lecheniia i profilaktiki kleshchevogo éntsefalita.

The antiviral activity of iodantipyrine was studied in outbred [correction of inbred] albino mice (weight 10-12 g) infected with the Absettarov strain of the tick-borne encephalitis virus. Iodantipyrine was administered per os or parenterally and the animals were observed for 21 days. A reliable therapeutic effect was produced in 60% of mice infected with 10 DL50 of tick-borne encephalitis virus which were given the drug per os in a dose of 50 mg/kg. Preventive administration of the drug was effective in 47% of the animals.

[The therapeutic and prophylactic effect of 4-iodoantipyrine in experimental tick-borne encephalitis]. / Lechebnyi i profilakticheskii éffekt 4-iodantipirana pri éksperimental'nom kleshchevom éntsefalite.

The antiviral activity of iodantipyrine-4 belonging to the group of nonsteroid anti-inflammatory compounds was studied in inbred white mice of 10-12 g given a single subcutaneous injection of the Absettarov strain of tick-borne encephalitis virus. Iodantipyrine-4 in different doses was administered orally or parenterally, and the animals were observed for 21 days. In the group of mice infected with 10 LD50 of TBE virus which were treated with the drug orally in a dose of 50 mg/kg a reliable therapeutic effect was established in 60%, after parenteral injection in 53.4%. Prophylactic administration of the drug followed by challenge with 10 LD50 of virus was effective in 47% of mice. In the group of mice infected with 100 LD50 of the virus the therapeutic effect was observed in 38% and prophylactic in 30%. Iodantipyrine-4 was found to induce interferon production.

[Isolation of split and whole-virion tick-borne encephalitis vaccines in an experiment and the characteristics of their immunogenic and antigenic properties]. / Poluchenie rasshcheplennoi i tsel'novirionnoi vaktsin kleshchevogo éntsefalita v éksperimente i kharakteristika ikh immunogennykh i antigennykh svoistv.

The split preparation, obtained by the treatment of purified and concentrated tick-borne encephalitis virus with 0.5% Tween-80 and ether and inactivated with formalin at a minimal concentration of 1:10,000, did not contain the active virus. After the removal of the detergent, the preparation retained its antigenic and immunogenic properties.

[Effect of immunosuppressants on the enhanced sensitivity of white mice to the eastern equine encephalitis virus]. / Vliianie immunosupressantov na povyshenie chuvstvitel'nosti belykh myshei k virusu vostochnogo éntsefalomielita loshadei.

EEE virus infection could be induced in white mice whose natural resistance to this virus had been reduced by immunosuppressive drugs such as: Adreson, Cyclophosphan and hydrocortisone.

[Molecular biology characteristics of an attenuated mutant of the Eastern equine encephalomyelitis virus]. / Molekuliarno-biologicheskaia kharakteristika attenuirovannogo mutanta virusa vostochnogo éntsefalomielita loshadei.

The main molecular biology parameters of an attenuated mutant DMS-20/6 of eastern equine encephalomyelitis virus derived by treatment with dimethylsulphate of the wild type virus (strain No. 627) were determined. The sedimentation coefficient of sucrose density gradient purified and concentrated virus was 280 S, the buoyant density of virions in sucrose density gradient was 1.19 g/cm3. The DMS-20/6 virion had 3 proteins with molecular weights of 56, 50, and 34 kilodaltons, and the size of virions by negative staining was 58-77 nm.