RESUMO
Background: Investigating possible relationship between Mucin1 expression levels in saliva, gustatory function, and taste perception in postmenopausal females. Material and Methods: Using whole mouth taste test, twenty-five post-menopausal females (51.35 ± 5.22 years) and twenty-five premenopausal females (39.65 ± 6.46 years) were prospectively evaluated for gustatory function. The expression of mucin1 was investigated; RNA was isolated from stimulated whole saliva samples and real-time PCR was used to determine mucin1 mRNA levels relative to bactin and GAPDH mRNA levels. Results: Significant difference was observed between postmenopausal and premenopausal women regarding intensity judgments of all tastants. The difference was more evident for sucrose taste perception (p<0.00001). Mucin1 expression levels were significantly decreased in postmenopausal females compared with premenopausal ones (p<0.00001). Mucin1 expression level had significant negative correlation with the salt taste sensitivity but did not correlate significantly with intensity judgments of the other tastants. Conclusions: Postmenopausal women have a reduced gustatory function, especially sucrose. Mucin1 expression was significantly decreased in postmenopausal females and had a significant negative correlation with the salt taste sensitivity. However, no correlation was found between mucin1 expression level and taste sensitivity of other tastants. Key words:Gustatory function, MUC1, taste, postmenopausal.
