RESUMO
Nineteen transfusion-dependent beta-thalassemia major patients were included in the study. Six of these patients underwent chelation therapy with desferrioxamine by subcutaneous infusion (50 mg/kg/12 hr) and 13 received intravenous infusion (50 mg/kg/6 hr or 100 mg/kg/24 hr). BUN, creatinine, creatinine clearance, beta 2-microglobulin, urinary beta 2-microglobulin and urinary growth hormone excretion were evaluated during desferrioxamine treatment. Thirteen out of nineteen patients presented tubular damage indicated by increased excretion of urinary beta 2-microglobulin. 85% (11 of 13) of these patients showed more serious tubular damage, as demonstrated by concurrent increased urinary growth hormone excretion. Moreover, a positive correlation between urinary growth hormone excretion and urinary beta 2-microglobulin was observed (P < 0.05).
Assuntos
Desferroxamina/efeitos adversos , Nefropatias/induzido quimicamente , Nefropatias/diagnóstico , Talassemia beta/terapia , Administração Cutânea , Adolescente , Adulto , Criança , Pré-Escolar , Desferroxamina/administração & dosagem , Desferroxamina/uso terapêutico , Ensaio de Imunoadsorção Enzimática , Feminino , Hormônio do Crescimento/urina , Humanos , Ensaio Imunorradiométrico , Infusões Intravenosas , Testes de Função Renal , Masculino , Microglobulina beta-2/urina , Talassemia beta/urinaRESUMO
We observed 12 very preterm infants (10 males) with a peculiar respiratory syndrome characterized by early onset soon after birth and by a biphasic course. The severe first phase was characterized by a clinical pattern mimicking the idiopathic respiratory distress syndrome of prematurity. Gradually, respiratory symptoms decreased and assisted ventilation with oxygen therapy was reduced. In the second phase, a significant worsening of respiratory signs and the appearance of apneic spells were observed. Chest X-ray showed hypoexpansion of the lungs and the prevalence of a fine reticular pattern. Chlamydia trachomatis was identified in this second phase in conjunctival and pharyngeal swabs and/or on tracheal aspirates. Our data suggest that in the very preterm infants, chlamydial infection shows different clinical and laboratory features if compared with Chlamydia trachomatis pneumonia of infants born at term.
Assuntos
Infecções por Chlamydia/diagnóstico , Chlamydia trachomatis , Recém-Nascido Prematuro , Pneumonia/diagnóstico , Insuficiência Respiratória/etiologia , Antibacterianos/uso terapêutico , Infecções por Chlamydia/complicações , Infecções por Chlamydia/terapia , Feminino , Hospitais Universitários , Humanos , Recém-Nascido , Unidades de Terapia Intensiva Neonatal , Masculino , Pneumonia/complicações , Pneumonia/terapia , Respiração com Pressão Positiva , Insuficiência Respiratória/epidemiologia , Cidade de Roma/epidemiologiaRESUMO
The increased occurrence of genital infections from Chlamydia trachomatis (Ct) suggested the need for a simple, rapid, sensitive method for detection of Ct. The purpose of the present study was to select symptomatic or asymptomatic women through two fast screenings: Pap-test and direct immunofluorescence (IF) test with monoclonal antibody. From 1,816 cervical cytology samples, 32 (1.76%) were selected for intracytoplasmic inclusions pathognomonic of Ct infection. Only 19 women underwent a check-up. The direct IF gave positive results in ten cases out of 19 (52.63%), and culture in eleven (57.89%). A correlation was made between the direct IF test and culture and also between cytologic and colposcipc findings. We thus conclude that direct IF, for its specificity, sensitivity, easy execution and low cost, could be currently utilized when clinical signs or Pap smears are suggestive of Ct infections.
