RESUMO
Studies of diabetogenic properties of Coxsackie A13 and B4 viruses in mice sensitive to diabetes (males, DBA line) and resistant (males and females F1(CBA X C57BL/6), females DBA/2 using in the latter case the subdiabetogenic doses of alloxan revealed in the infected animals biochemical changes manifested by reduction of glucose tolerance and disorders in the synthesis of immunoreactive insulin. Most marked changes were observed in males of DBA/2 line infected with Coxsackie B4 virus and in males F1 (CBA X C57BL/6) and females DBA/2 infected with Coxsackie A14 virus. With Coxsackie A13 virus such data have been obtained for the first time.
Assuntos
Infecções por Coxsackievirus/complicações , Diabetes Mellitus Experimental/etiologia , Enterovirus Humano B/patogenicidade , Enterovirus/patogenicidade , Animais , Antígenos Virais/análise , Glicemia/análise , Infecções por Coxsackievirus/sangue , Infecções por Coxsackievirus/imunologia , Diabetes Mellitus Experimental/sangue , Diabetes Mellitus Experimental/imunologia , Suscetibilidade a Doenças , Enterovirus/imunologia , Enterovirus Humano B/imunologia , Feminino , Anticorpos Anti-Insulina/análise , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Camundongos Endogâmicos DBA , Miocárdio/imunologia , Pâncreas/imunologia , Fatores de TempoRESUMO
The influence of Coxsackie B4 and AI3 viruses on the pancreas of mice (resistant and susceptible to diabetes) was studied. Glucose intolerance and changes in the synthesis of immunoreactive insulin were detected in all the treated groups of animals. Biochemical changes were more prominent in male DBA/2 mice, infected with Coxsackie B4 virus, in FI (CBA X C57Bl/6) hybrids and in female DBA/2 mice infected with Coxsackie AI3 virus and alloxan.