Lipid peroxidation and state of the erythron in newborn rats under normal conditions and impairment of sensorimotor reflexes.

Specimens with a stereotypic sensorimotor deficit were revealed among newborn rats due to abnormalities in prenatal ontogeny and birth stress. Genetically determined differences in the total lipid content of blood plasma were found in Wistar and August rat pups. Hence, LPO processes were shown to differ in these animals. August rats with intense lipid metabolism were characterized by higher activity of LPO in comparison with Wistar rats. The increase in LPO was associated with a relatively low activity of antioxidant enzymes. Impairment of sensorimotor reflexes in newborn Wistar and August rats was accompanied by suppression of the erythron and activation of extravascular hemolysis.

[Prognostic value of the content of lipid peroxidation products in tissues at pancreatic necrosis]. / Prognosticheskoe znachenie soderzhaniia produktov lipoperoksidatsii v tkaniakh pri pankreonekroze.

The exact role of lipid peroxidation in pathogenesis of pancreatonecrosis was established by means of studying the level of dienic conjugates and malonic dialdehyde in the intraoperative bioptates of the pancreas, liver, lymph nodes of the lesser omentum in 40 patients as well as in the autopsy material (similar tissues, spleen and bone marrow) in 18 patients dead of destructive pancreatitis. The control group included 10 patients dead of sudden death (normal), group of comparison (those who died of acute myocardium infarction--10 subjects) and of acute surgical abdominal pathology not associated with pancreatitis (10 subjects). Demonstrable activation (6-10 times) of processes of lipid peroxidation in all the bioptates under study took place at pancreatonecrosis as compared to the normal that suggests generalization of lipid peroxidation at this pathology. The level of lipid peroxidation can show the degree of destruction in the pancreas that can be considered as a criterion of the outcome of the disease. In the groups of comparison the level of lipid peroxidation was much lower than at pancreatonecrosis that suggests the pathogenetic role of activation of lipid peroxidation in the development of this disease.