[EFFICIENCY OF CONCOMITANT USE OF POLICOSANOL AND ROSUVASTATIN IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE AND MODERATE HEPATIC DYSFUNCTION].

The article presents the results for the study of lipid correction capacity and safety of concomitant use of policosanol and rosuvastatin compared with rosuvastatin monotherapy in patients with stable coronary artery disease and moderate hepatic dysfunction. Fifty-seven subjects aged 37 to 72 years (mean age 54.4 years +/- 6.5 years) have been enrolled into the study with the following inclusion criteria: therapy with statins for more than 8 weeks, failure to achieve target LDL cholesterol levels and moderately elevated liver enzymes. The following laboratory tests were performed at baseline and after 12 weeks of follow-up: blood lipid profile (total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), high density lipoprotein cholesterol (HDL-C) and triglycerides (TG), lipid peroxidation (ma- Ionic dialdehyde (MDA), glycosylated hemoglobin HbAlc (%) and liver function tests (gamma-glutamyl transpeptidase-gamma-GTP) and alanine aminotransferase (ALT). Concomitant use of policosanol with rosuvastatin was superior to rosuvastatin monotherapy in terms of reduction of pro-aterogenicity of lipid metabolism by decreasing serum TC, LDL-C and TG, increasing serum HDL-C and decreasing the pro-oxidative activity (MDA) with simultaneous substantial improvement of hepatic function. Concomitant use of policosanol at the dose of 20 mg/day and rosuvastatin at 10-20 mg/day was favorably tolerated. None of the subjects had any discontinuations of therapy due to adverse events.

[Role of family practice in prevention of ischemic heart disease]. / Simeina medytsyna ta ïï rol' u profilaktytsi ishemichnoï khvoroby sertsia.

Family medicine as a system of primary medical care delivery to man and his family can become under conditions of this country a mainstay of a successful realization of preventive strategies for chronic noninfectious diseases, and, in the first place, for ischemic heart disease. The article presents a project of a simplified scheme of actions for a family physician to carry on a prophylactic work among the population of his sector community. The stages the above scheme involves are as follows: assessment of an individual and general populational risk, dividing of the population into main groups of risk, implementation of measures designed to carry on a program of intervention intended for each group of the population with special reference to individual traits.

[The effect of lead compounds on the development of arterial hypertension in workers in the radio electronics industry]. / Vplyv spoluk svintsiu na rozvitok arterial'noï hipertenziï u pravtsivnykiv radioelektronnoï promyslovosti.

As many as 2723 workmen aged 15-64 years (1736 women, 987 men) from a radio electronic industry enterprise were examined with the purpose of finding out the prevalence of arterial hypertension (including borderline and persistent ones), depending on the length of service, in two different occupational groups: the basic one consisting of those exposed to lead compounds occupationally, and control one. The examination showed that the level of dynamics of the AH patient relative numbers was significantly higher in those contingents of workmen who had been occupationally exposed to lead compounds for long periods of time.