[A method for the primary selection of immunomodulators by the level of 5'-nucleotidase activity in the macrophages of peritoneal exudate]. / Sposob pervichnogo otbora immunomoduliatorov po urovniu aktivnosti 5'-nukleotidazy makrofagov peritoneal'nogo ékssudata.

A method of primary selection of immunomodulators based on measuring of ecto 5'-nucleotidase activity level of macrophages of peritoneal exudate was developed. Immunostimulators were found to decrease the activity level, while immunosuppressors increased the activity. The preparations having no immunomodulatory effect do not change the activity of this enzyme.

[Effect of T-activin on macrophage 5'-nucleotidase activity and blood cortisol level depending on the time of day]. / Osobennosti vliianiia T-aktivina na aktivnost' 5-nukleotidazy makrofagov i uroven' kortizola krovi v zavisimosti ot vremeni sutok.

Peculiarities of T-activin influence on macrophage 5-nucleotidase and blood cortisol in dependence of day time have been investigated on CBA and C57/B16 mice. It has been established that T-activin influence on already studied indexes in broad range of doses; from 10 to 1 mkg for 1 mouse.

[The normalizing effect of dalargin on the glucocorticoid and opioid levels of the blood in CBA and C57Bl/6 mice undergoing footshock stress]. / Normalizuiushchee vliianie dalargina na uroven' gliukokortikoidov i opioidov v krovi myshei linii CBA i C57Bl/6 v usloviiakh footshock-stressa.

Radioreceptor investigations showed that it is impossible to interpret changes in the activity of opioid receptor ligands of mu and delta types in plasma of mice under footshock stress (FSS) as activation or depletion of opioid system (OS). There occurred qualitative changes characterized by interstrain differences (ID). These are also typical for dynamics of development of FSS effects on blood corticosterone levels. Administration of dalargin diminishes qualitative and quantitative changes in OS function at different periods after FSS preventing early rise of corticosterone levels after the exposure. In spite of common features in dalargin action on opioid and steroid metabolism in mice of both strains, ID are also present.

[The effect of dalargin on stress-induced changes in the 5'-nucleotidase activity of the macrophages and in the level of endogenous blood cortisol in mice]. / Vliianie dalargina na stress-indutsirovannoe izmenenie aktivnosti 5'-nukleotidazy makrofagov i urovnia éndogennogo kortizola krovi myshei.

The action of dalargin, synthetic analogue of leuenkephaline, on stress-induced changes in 5'-nucleotidase activity and endogenous hydrocortisone levels was investigated in mice. It was found that there is a direct relation between the activity of 5'-nucleotidase and the level of hydrocortisone in CBA mice. For C57Bl/6 mice the relation was inverse. Dalargin is able to change the dependence from direct to opposite in CBA mice.

[Characteristics of immunomodulating effect of histamine in inbred strain mice]. / Osobennosti immunomoduliruiushchego deistviia gistamina u myshei inbrednykh linii.

The activity of 5'-nucleotidase of peritoneal exudate in subcutaneous injection of histamine in a dose of 1.0-100 microliters was studied in mice of different lines (CBA, C57, B1/6, Balb/c, NFS/n, NFR/n). There were interline differences in the influence of histamine on this metabolic index.

[Sensitivity to mouse toxin and level of macrophage 5-nucleotidase activity]. / Chuvstvitel'nost' k myshinomu toksinu i uroven' aktivnosti 5-nukleotidazy makrofagov.

It is shown that immunomodulator of bacterial origin salmozan causes alternations of sensitivity to mouse toxin in mice CBA. A correlation exists between the sensitivity to mouse toxin and the level of 5-nucleotidase of peritoneal exudate macrophages.

[The immunomodulating action of the surface antigens of the influenza A virus in experimental staphylococcal infection]. / Immunomoduliruiushchee deistvie poverkhnostnykh antigenov virusa grippa A pri éksperimental'noi stafilokokkovoi infektsii.

The results of the study of influenza A virus surface antigens, hemagglutinin and neuraminidase, in the induction of nonspecific immunomodulation and protection from acute pulmonary staphylococcal infection have been studied. Protective effect, the cell composition of bronchoalveolar lavage fluid depend on the serological subtypes of surface antigens used for intranasal immunization and the infective dose of staphylococci.