Organic-Inorganic Hybrid Nanocomposites for Nanotheranostics: Special Focus on Preventing Emerging Variants of SARS-COV-2.

The worldwide emerging cases of various respiratory viral diseases and the current escalation of novel coronavirus disease (COVID-19) make people considerably attentive to controlling these viruses through innovative methods. Most re-emerging respiratory diseases envelop RNA viruses that employ attachment between the virus and host cell to get an entry form using the host cell machinery. Emerging variants of COVD-19 also bring about a constant threat to public health as it has wide infectivity and can quickly spread to infect humans. This review focuses on insights into the current investigations to prevent the progression of incipient variants of Severe Acute Respiratory Syndrome Coronavirus (SARS-COV-2) along with similar enveloped RNA viruses that cause respiratory illness in humans and animals. Nanotheranostics is a trailblazing arena of nanomedicine that simultaneously helps prevent or treat diseases and diagnoses. Nanoparticle coating and nanofibers were extensively explored, preventing viral contaminations. Several studies have proven the virucidal activities of metal nanoparticles like copper, silver, and titanium against respiratory viral pathogens. Worldwide many researchers have shown surfaces coated with ionic nanoparticles like zinc or titanium act as potent antiviral agents against RNA viruses. Carbon nanotubes, quantum dots, silica nanoparticles (NPs), polymeric and metallic nanoparticles have also been explored in the field of nanotheranostics in viral detection. In this review, we have comprehensively discussed different types of metallic, ionic, organic nanoparticles and their hybrids showing substantial antiviral properties to stop the progression of the novel coronavirus disease focused on three key classes: prevention, diagnostics, and treatment.

Association of sociodemographic and reproductive variables with menopause-specific quality of life using principal component analysis.

We aimed to determine whether sociodemographic and reproductive variables jointly or independently were associated with menopause-specific quality of life (MENQOL). A total of 250 Bengali-speaking Hindu women (peri- and postmenopausal) were recruited from West Bengal, India. Data on MENQOL (vasomotor, physical, psychosocial, sexual, and quality-of-life domains), sociodemographic, and reproductive variables were collected. Principal component (PC) analysis was used to identify PCs for sociodemographic and/or reproductive variables: PC1 (sociodemographic), PC2 (sociodemographic and reproductive), PC3, and PC4 (reproductive). PC scores were used in multiple regression analyses to determine associations with MENQOL. For perimenopausal women, PC1 and PC3 were inversely associated with the sexual domain; PC2 was positively associated with vasomotor, sexual domain, and quality of life; and PC3 was positively associated with the physical domain. For postmenopausal women, PC1 and PC3 were inversely associated with the sexual and psychosocial domains, respectively; PC2 was positively associated with the sexual domain and quality of life; and PC4 was positively associated with the psychosocial domain. The factors associated with MENQOL PCs were similar for perimenopausal and postmenopausal women. Health planners should consider early and midlife factors associated with MENQOL to improve women's midlife health.

Weight concerns and food habits of adolescent girls in two contrasting ecological regions: A comparative study in India.

OBJECTIVE: To compare the incidence of weight concerns and food habits between two ethnically different groups of adolescent girls residing in two distinct ecological settings: the plains of Kolkata and the mountains of Sikkim. METHODS: Two separate cross-sectional studies were conducted within a period of five years in urban hilly areas of Sikkim and the city of Kolkata, India. A total of 506 girls aged 14-19 years were selected from the study areas of Sikkim (n=224) and Kolkata (n=282). Girls were interviewed for weight concerns and food habits along with socio-demographic characteristics. Weight concerns were assessed with four variables such as, perceptions about own body weight, felt dissatisfied with own body weight, urge for dieting and use of weight reduction diet. Food habits included consumption of major foods during the past one week. RESULTS: Bivariate analyses showed that Kolkata girls perceived themselves as overweight, remained dissatisfied with body weight, expressed perceived need for dieting and followed weight reduction diet more compared to the girls of Sikkim. Food habits indicated that all Sikkimese girls preferred to consume cereals regularly, while Kolkata girls consumed vegetables, pulses, fish, fruits, bread and butter and fried foods more than Sikkimese girls. Multivariate analyses showed that place of residence was significantly (p<0.05) associated with both weight concerns and food habits of girls. CONCLUSION: Diversity in culture, ethnicity and socio-economic standard perhaps develop the disparity in food habits and weight concerns between girls of urban hilly areas of Sikkim and the city of Kolkata.

Body weight and body shape concerns and related behaviours among Indian urban adolescent girls.

OBJECTIVE: To assess the associations of body weight and body shape concerns and related behaviours with actual weight status among urban adolescent girls. DESIGN: In the present cross-sectional study, a self-administered questionnaire was used to collect data on body weight and body shape concerns and related behaviours. Sociodemographic information was collected using a pre-tested schedule. Weight and height of each girl were measured to assess actual weight status. SETTING: Twin cities of Kolkata and Howrah, West Bengal, India. SUBJECTS: A total of 1223 adolescent girls aged 14-19 years were selected from nine schools in Kolkata and Howrah in West Bengal. RESULTS: Many overweight girls perceived themselves as overweight and engaged in weight-reducing activities. However, several normal-weight girls also perceived them as overweight and attempted to lose weight. Unhealthy eating practices to reduce weight were followed by both overweight and normal-weight girls and even by a few underweight girls. Multivariate binary logistic regression showed a significant association between actual weight status and use of unhealthy weight-loss measures. The likelihood of adopting unhealthy eating practices was significantly higher among overweight than normal-weight girls. CONCLUSIONS: Health education programmes should be introduced at schools to promote effective weight-control practices that help dispel myths about weight loss.

Menopause-specific quality of life of urban women in West Bengal, India.

OBJECTIVE: To find out the association of menopause-specific quality of life of women with both working status and duration of postmenopausal years. STUDY DESIGN: We conducted a cross-sectional study on 250 postmenopausal women belonging to Bengali-speaking Hindu ethnic group, aged 47-62 years in the city of Kolkata, West Bengal, India. The participants were literate, living in wedlock with at least one surviving child, attained natural menopause at least two years ago and have never taken hormone replacement treatment. Menopause-specific quality of life was measured using a self-administered standard questionnaire (Menopause-Specific Quality of Life questionnaire, or MENQOL). MENQOL consisted of 29 menopausal symptoms (items) that are grouped under four domains. Additional information on sociodemographic aspect and reproductive history of the participants were collected using a pretested questionnaire. Main outcome measures Both bivariate and multivariate analyses showed that menopause-specific quality of life decreases with the increase in duration of postmenopausal years. Although bivariate analysis demonstrated that working women had a better menopause-specific quality of life than their non-working counterpart, multivariate linear regression model did not corroborate to this finding. CONCLUSION: Duration of postmenopausal years had a significant association with menopause-specific quality of life of women.