Tumor-induced hypophosphatemia.

Significant hypophosphatemia is commonly due to Vitamin D deficiency. Any sporadic onset of hypophosphatemia in adults warrants workup to identify alternate causes. Hypophosphatemia may also be the only manifestation of an occult malignancy. A high index of clinical suspicion can help diagnose such conditions in early stages. Prompt treatment of the cause can correct this biochemical abnormality. We describe a case report of a woman presenting with severe hypophosphatemia and osteomalacia, leading eventually to the diagnosis of a phosphaturic mesenchymal tumor of the temporo-occipital bone. Surgical resection of tumor led to normalization of the biochemical parameters as well as a complete clinical recovery.

Effect of phenelzine, a monoamine oxidase inhibitor, on isoproterenol-induced myocardial damage.

The effect of phenelzine on isoproterenol-induced myocardial necrosis was studied in rats. Male albino rats were pretreated with 20 mg/kg body wt of phenelzine, intraperitoneally, on 4 consecutive days. The same animals were given 80 mg/kg of isoproterenol subcutaneously on the third and fourth days of the study. After 48 hr of isoproterenol, ECG was recorded, the animals were killed, and blood, heart, and adrenal glands were removed for biochemical and histopathological studies. Phenelzine returned toward normal the isoproterenol-induced decreased in cardiac glycogen but decreased serum lactic acid only slightly toward normal. The serum enzymes, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT), showed the protective effect of phenelzine. The increase in isoproterenol-induced free fatty acid (FFA) was significantly reduced in the group pretreated with phenelzine. Our studies on adrenal ascorbic acid suggest that the animals pretreated with phenelzine suffered less stress compared to the group treated with isoproterenol alone. Histopathological changes including focal areas of necrosis and characteristic cellular exudation were less marked in the hearts of rats pretreated with phenelzine. S-T segment elevation was more marked in the group treated with isoproterenol only.