RESUMO
PURPOSE: To prospectively investigate the effect of thyroid arterial embolization on hyperthyroid Graves' disease in selected patients. MATERIAL AND METHODS: Twenty-eight patients with hyperthyroidism caused by Graves' disease were enrolled to undergo thyroid arterial embolization and followed up for 12-22 months. Twenty-two patients had three thyroid arteries embolized and six patients two arteries. Serum thyroid hormone, thyroid-stimulating hormone (TSH), and autoimmune function were tested before and after embolization in all patients. RESULTS: Of 28 patients, 22 (78.6%) became euthyroid, five improved (17.8%), and one had temporary improvement followed by recurrence (3.6%). No serious complications occurred. Compared with the pre-embolization values, serum concentrations of thyroid hormone increased temporarily on day 3 post-embolization, dropped substantially after 1 and 2 months, and returned to nearly normal at 6 and 12 months post-embolization. TSH dropped on day 3, increased after 1 and 2 months, and returned to normal after 6 and 12 months. Thyroid antibodies TGAb and TMAb declined on day 3 to normal range, rose after 1 month, dropped to normal again after 2 months, and were slightly increased at 6 and 12 months follow-up. CONCLUSION: Thyroid arterial embolization may be an effective approach for patients with hyperthyroidism caused by Graves' disease.
Assuntos
Embolização Terapêutica/métodos , Doença de Graves/terapia , Adolescente , Adulto , Análise de Variância , Angiografia , Feminino , Doença de Graves/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Testes de Função Tireóidea , Glândula Tireoide/irrigação sanguínea , Resultado do Tratamento , Ultrassonografia DopplerRESUMO
Red cell immunocompetence was studied in 38 cases of heroin addicts by measuring the rate of red blood cell C3b receptor rosette (RBC-C3bRR), and red blood cell immune complex rosette (RBC-ICR) the concentration of complement C3 and the content of circulating immune complex (CIC). The results showed that the rate of RBC-C3bRR and RBC-ICR and C3 concentration in the heroin addicts decreased significantly, while their CIC content increased significantly as compared with those of the controls. It was also found that the duration of drug taking was related with the changes of the rate of RBC-C3bRR and RBC-ICR, C3 concentration and CIC content. It is suggested that red cell immunoadherence function in heroin addicts decreases significantly as to influence the clearance of CIC.
