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1.
J Asian Nat Prod Res ; 24(5): 432-444, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35435775

RESUMO

Seven new minor monoterpene derivatives (1-7), together with six known analogues, were isolated from an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (Gou-teng). Their structures were determined by spectroscopic data analysis and electronic circular dichroism (ECD) calculations, of which 1 was confirmed by single crystal X-ray diffraction.


Assuntos
Uncaria , Estrutura Molecular , Monoterpenos , Uncaria/química , Água
2.
Nat Prod Res ; 34(16): 2283-2288, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30580623

RESUMO

A new indole alkaloid, 17-oxo-19-(Z)-naucline, and six known alkaloids 2-7 were isolated from the branches of Nauclea officinalis. The structure of the new compound 1 was characterised mainly by analysing its physical data including IR, 1 D, 2 D NMR, and HR-ESI-MS. Other compounds were identified by comparisons their data with those reported in the literature. Compound1, 4, 5, 6, 7 showed in vitro anti-inflammatory activity decrease the LPS-stimulated production of nitric oxide in RAW264.7 cell, while all compounds exhibited weak cytotoxicity against human tumour cell lines (LOVO, A549 and HepG2).


Assuntos
Anti-Inflamatórios/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Alcaloides Indólicos/farmacologia , Rubiaceae/química , Alcaloides/química , Alcaloides/isolamento & purificação , Alcaloides/farmacologia , Animais , Anti-Inflamatórios/química , Anti-Inflamatórios/farmacologia , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/isolamento & purificação , Linhagem Celular Tumoral , Humanos , Alcaloides Indólicos/química , Alcaloides Indólicos/isolamento & purificação , Camundongos , Estrutura Molecular , Óxido Nítrico/antagonistas & inibidores , Óxido Nítrico/metabolismo , Células RAW 264.7
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