RESUMO
Two new sesquiterpenoid glycosides as dihydrophaseic acid 4'-O-[6â³-O-(4â³'-hydroxy-3â³', 5â³'-dimethoxy) benzoyl)]-ß-D-glucopyranoside (1) and dihydrophaseic acid 4'-O-[6â³-O-(3â³'-methoxy- 4â³'-hydroxy) benzoyl)]-ß-D-glucopyranoside (2), were isolated from the stems of Zanthoxylum armatum in the study. The compound 1 and 2 showed moderate scavenging activity in DPPH free radical assay with IC50 values of 241 and 264 µM, respectively.
Assuntos
Sesquiterpenos/química , Zanthoxylum/química , Compostos de Bifenilo/química , Sequestradores de Radicais Livres/química , Glicosídeos/química , Estrutura Molecular , Picratos/química , Extratos Vegetais/química , Caules de Planta/químicaRESUMO
One new compound, Colletotrichine A (1), was produced by the fungal Colletotrichum gloeosporioides GT-7. The structure was established by 1D and 2D NMR spectra. Monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibitory activity of 1 was also evaluated. Compound 1 showed AChE-inhibiting activity with IC50 value of 28 µg/mL.
Assuntos
Inibidores da Colinesterase/química , Colletotrichum/química , Inibidores da Monoaminoxidase/química , Sesquiterpenos/química , Uncaria/microbiologia , Inibidores da Colinesterase/farmacologia , Endófitos/química , Concentração Inibidora 50 , Inibidores da Monoaminoxidase/farmacologia , Sesquiterpenos/farmacologiaRESUMO
Two new phenolic glycoside, 2-methoxy-4-hydroxylphenyl-1-O-α-L-rhamnopyranosyl- (1â³ â 6')-ß-D-glucopyranoside. (1) and threo-3-methoxy-5-hydroxy-phenylpropanetriol-8-O-ß-D-glucopyranoside (2), were isolated from the stems of Zanthoxylum armatum. The compounds 1 and 2 showed weak scavenging activity in DPPH free radical assay with IC50 values of 323 and 114 mM, respectively.
