1.
Org Biomol Chem
; 14(46): 11002-11012, 2016 Nov 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27827507
RESUMO
F-THENA is designed as an alternative fluorine-containing chiral derivatizing agent (CDA). The fluorine atom functions exclusively as a reporter which can directly sense an anisotropic effect from an aromatic substituent of a chiral alcohol. In combination with chemical shift differences from both 19F NMR and 1H NMR, the F-THENA method can successfully be used for determining the absolute configuration of chiral secondary aromatic alcohols with a self-validating system.