RESUMO
Endocrine dysfunctions were associated at different stages of infection, including those early in the course of HIV infection. In fact adrenal insufficiency, hyporeninemic hypoaldosteronism, hyponatremia, reduced gonadotropins levels, gonadal abnormalities and changes in hormone-binding proteins were reported in HIV infection. Also a thyroid involvement with autoimmune phenomena was observed in HIV infection by several studies giving different explanations of altered thyroid conditions. These findings suggest an effect of HIV on endocrine system. Recognition of endocrine manifestations in these patients may contribute to better characterize different stages of the infection and improve the management of HIV patients.
Assuntos
Doenças do Sistema Endócrino/complicações , Infecções por HIV/fisiopatologia , Glândula Tireoide/fisiopatologia , Infecções Oportunistas Relacionadas com a AIDS/complicações , Infecções Oportunistas Relacionadas com a AIDS/fisiopatologia , Glândulas Suprarrenais/fisiopatologia , Autoanticorpos/análise , Síndromes do Eutireóideo Doente/complicações , Infecções por HIV/complicações , Humanos , Pâncreas/fisiopatologia , Hipófise/fisiopatologia , Tireoidite Autoimune/complicaçõesRESUMO
The results of five years activity of the National Register of children with Congenital Hypothyroidism (NRCH) have been evaluated. NRCH was established in Italy in 1987, as a pilot project of Health Ministry. All Italian Centers in charge of the screening, treatment and follow-up of CH are involved in the program. The results have provided further epidemiological informations about CH in Italy and have evidenced some aspects in the screening organization which had to be improved. Discussion of Register data in annual meetings has recently allowed to obtain an improvement especially for the beginning of treatment and the used dose of therapy.
