RESUMO
BACKGROUND: Liquid biopsy and Integrative Genomic Profiling (IGP) are yet to be implemented into routine Radiation Oncology. Here we assess the utility of germline, tumour and circulating cell-free DNA-based genomic analyses for the clinical management of early-stage and oligometastatic cancer patients treated by precision radiotherapy. METHODS: We performed germline, tissue- and liquid biopsy NGS panels on 50 early-stage/oligometastatic cancer patients undergoing radiotherapy. We also monitored ctDNA variants in serial liquid biopsies collected during radiotherapy and follow-up and evaluated the clinical utility of such comprehensive approach. RESULTS: The integration of different genomic studies revealed that only 1/3 of the liquid biopsy variants are of tumour origin. Altogether, 55 tumour variants (affecting 3/4 of the patients) were considered potentially actionable (for treatment and prognosis), whereas potential follow-up biomarkers were identified in all cases. Germline cancer-predisposing variants were present in three patients, which would have not been eligible for hereditary cancer testing according to clinical guidelines. The presence of detectable ctDNA variants before radiotherapy was associated with progression-free survival both in oligometastatic patients and in those with early-stage. CONCLUSIONS: IGP provides both valuable and actionable information for personalised decision-making in Radiation Oncology.
Assuntos
DNA Tumoral Circulante , Neoplasias , Radioterapia (Especialidade) , Humanos , DNA Tumoral Circulante/genética , Biomarcadores Tumorais/genética , Biópsia Líquida , Genômica , MutaçãoRESUMO
This study explored the relationship between different indicators of acculturation and children's caries experience. Data from 313 children attending the Dental Clinic of the European University of Madrid were analysed. Acculturation was measured via generational status, age at arrival, length of residence and language spoken at home. The association between each indicator of acculturation and caries experience was assessed in Poisson regression models adjusting for confounders. First- and second-generation migrant children had greater caries experience than Spanish-born children. These differences only persisted for first-generation migrant children after adjustment for confounders. Children who arrived in Spain before age 6 years, who lived in Spain for 10 or more years and who spoke a language other than Spanish at home had greater caries experience than Spanish-born children. Inequalities in caries experience between migrant and native children were evident (favouring the local children) and independent of family's socioeconomic circumstances.
Assuntos
Aculturação , Cárie Dentária/epidemiologia , Migrantes/estatística & dados numéricos , Adolescente , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Espanha/epidemiologia , Inquéritos e QuestionáriosRESUMO
Construcción de marcos muestrales para tres programas de desnutrición según los objetivos de la Encuesta de línea de Base, Diseño de la Muestra y actividades conexas al diseño
Assuntos
Masculino , Feminino , Humanos , Distúrbios Nutricionais , BolíviaRESUMO
Una técnica de gingivectomía se describe paso a paso. El práctico general, al leer el trabajo de la Dra. Rossitch, se podrá percatar no tan sólo de las tendencias actuales que rigen los actos quirúrgicos para los enfermos periodonciopáticos, como también descubrirá la manipulación operatoria en su misma esencia(AU)
