1.
Org Biomol Chem
; 15(34): 7227-7234, 2017 Aug 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28816328
RESUMO
Acyclic nucleoside phosphonates have been prepared in a straightforward manner and in high yields by an enantioselective palladium-catalyzed allylic substitution involving nucleic bases as nucleophiles followed by cross-metathesis reaction with diethyl allylphosphonate.
Assuntos
Alcenos/química , Nucleosídeos/química , Organofosfonatos/química , Organofosfonatos/síntese química , Paládio/química , Aminação , Catálise , Técnicas de Química Sintética
2.
J Org Chem
; 81(12): 5217-21, 2016 06 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27182738
RESUMO
A formal enantioselective synthesis of nectrisine, a potent α-glucosidase inhibitor, was carried out starting from butadiene monoepoxide through a synthetic sequence involving enantioselective allylic substitution, cross-metathesis, dihydroxylation, and cyclization.