[The functional characteristics of the enzymatic antioxidant system in the erythrocytes and neutrophils of the blood of patients with generalized forms of meningococcal infection]. / Osobennosti funktsionirovaniia fermentnoi antioksidantnoi sistemy v éritrotsitakh i neitrofilakh krovi bol'nykh s generalizovannymi formami meningokokkovoi infektsii.

Patients with meningococcal infection, meningitis and with a mixed form of the disease were demonstrated to have unbalance in the redox system of glutathione during the all disease periods till the clinical recovery. Activation of glutathione peroxidases to hydrogen peroxide and tertiary butyl hydroperoxide in erythrocytes was coupled, during the whole disease, with unbalance of the time-course of changes in the interrelated enzymes--superoxide dismutase and glutathione peroxidase to hydrogen peroxide, while in neutrophils, the balance of those enzymes remained unimpaired. Glutathione transferase activity appeared reduced both in erythrocytes and neutrophils. Potential mechanisms by which the redox system of glutathione and superoxide dismutase may be deranged in meningococcal infection are under discussion.

[Effect of the lethal Bacillus anthracis toxin on phagocytosis and the dynamics of the change in the enzyme activity of the antioxidative system of peritoneal mononuclear phagocytes in mice with differing hereditary immunity to anthrax]. / Vliianie letal'nogo toksina Bacillus anthracis na fagotsitoz i dinamiku izmeneniia aktivnosti fermentov antiokislitel'noi sistemy peritoneal'nykh mononuklearnykh fagotsitov myshei s razlichnym nasledstvennym immunitetom k sibirskoi iazve.

It was demonstrated, that the lethal in vitro suppressed the phagocytic activity of peritoneal mononuclear phagocyte (Mph) and enhanced the level activity of glutathione peroxidase to H2O2 (GP-H2O2) in Mph of resistant to anthrax BALB mice. In Mph BALB the authors observed dependent-dose enhancement of GP-H2O2 activity and reduction of the ratio of level glutathione reductase (GR) to GP-H2O2 (GR/GP-H2O2). The enhancement of activity GR-H2O2 in Mph CBA was not dependent on the doses of toxin. The coefficient GR/GP-H2O2 was similar to the control. The mechanisms of hereditary resistance to anthrax were discussed.

[Early manifestations of the effect of Salmonella endotoxin on the antioxidizing enzyme systems of the liver and intestines in the rat]. / Rannie proiavleniia sal'monelleznogo éndotoksina na antiokislitel'nuiu fermentnuiu sistemu pecheni i kishechnika krys.

A study was made of the effect of salmonellosis endotoxin (SE) on the activity of glutathione transferase (GT), glutathione peroxidase (GP-GTB and GP-H2O2), glutathione reductase (GR) and superoxide dismutase (SOD) in cytosols of the rat jejunal mucosa and liver. The activity of all the test enzymes of both the small intestine and liver was marked by drastic changes at the early stages of SE action. Thus, the activity of SOD and GP-H2O2 in the liver decreased after 30 min or 1 h of endotoxin action, respectively. In the jejunal mucosa, the activity of GP-H2O2 and SOD dropped after 4 h of SE action. GT in the jejunum remained unchanged, whereas in the liver, it was activated. The activity of GR and GP-GTB in the liver and jejunum was dissimilar. The causes and consequences of the abnormalities of the antioxidant enzymatic system and the role they play in the pathogenesis of salmonellosis intoxication are discussed.