[Trends in the incidence of mental and behavioral disorders during the COVID-19 pandemic in Penza Oblast]. / Dinamika zabolevaemosti psikhicheskimi rasstroistvami i rasstroistvami povedeniya v period pandemii COVID-19 v Penzenskoi oblasti.

OBJECTIVE: An analysis of the trend of overall and primary incidence of mental and behavioral disorders, including those caused by the use of psychoactive substances, in different age groups during the COVID-19 pandemic in Penza Oblast. MATERIAL AND METHODS: The data were obtained from statistical report №12 for Penza Oblast. These included the overall and primary incidence of mental and behavioral disorders (MBD), as well as substance use-related MBD (MBDSUR), as calculated per 100.000 people for the period 2015 to 2022. The period 2015 to 2019 was the reference period and 2020 to 2022 was the pandemic period. The calculation was carried out by age groups: children (0-14 years), adolescents (15-17 years), adults (over 18 years), adults over working age (from 55 years for women and from 60 years for men). Statistical processing of the results included regression analysis, calculation of incidence forecast for 2023-2025, and assessment of the significance of the changes using the t-criterion. RESULTS: The decrease in the overall incidence of MBD in adults was highly deterministic (R2=0.82; p=0.012) and significant between 2017-2018 (p=0.009), 2018-2019 (p=0.001) and 2019-2020 (p=0.004). High determination with a logarithmic trend line was characteristic of almost all models, except for the primary incidence of MBD in children and overall incidence of MBDSUR in adults over working age, including after 2020. Among adolescents, the overall incidence of MBDSUR decreased significantly from 2015 to 2022 (p=0.042). CONCLUSION: There was no significant increase in the incidence of MBD, including MBDURS, during the pandemic. At the same time, there was a trend towards the decrease in adults, as well as the increase in the primary incidence of MBD in children and the overall incidence of MBDSUR in adults over working age, which determines the need for further identification of risk factors and development of specific rehabilitation measures for patients in these groups.

[The combined use of peptide bioregulators and self-massage in order to improve the psychophysiological state and increase the professional performance of the elderly.]

The development of modern society is characterized by an increase in the volume and changing forms of information presentation. In the works of Russian and foreign gerontologists, it is noted that the perception and analysis of the flow of relevant data today causes difficulties for a significant part of citizens of older age groups, which is due, among other things, to the deterioration of their psychophysiological state. The lack of the ability to use the necessary information negatively affects the quality of life, the level of social adaptation and professional competence. This problem is particularly significant for population groups and professional communities, whose life and activities require the actualization of certain sectors of the information field. Typical examples of such groups are citizens of retirement age who continue professional activities related to the mobilization of intellectual and creative potential, in particular, university teachers. The use of gerontotechnologies contributes to solving the problem, which provides for the development of effective methods for correcting the functional state of elderly citizens, in particular, increasing the ability to perceive information and the level of vital activity. This publication presents the results of an experimental study of the effectiveness of the combined use of peptide bioregulators and massage on the level of professional performance of elderly teachers of a pedagogical university.

[Accelerated aging as a risk of the education digitalization: possibilities for prevention.]

The work is devoted to the analysis of the education digitalization negative effects and the possibilities of their prevention consideration. The urgency of this problem in the modern conditions of combating the pandemic of the new coronavirus infection and moving a significant part of education and leisure to the virtual space is noted. Against the background of a deficit in physical activity and an increase in the information consumption duration, the participants in the experiment showed a significant increase in the frequency of mental and physical maladjustment symptoms occurrence, a decrease in performance indicators and a deterioration in the biological age parameters. The geroprotective effect of correcting the student lifestyle with an emphasis on information hygiene, optimizing sleep, rest, motor and nutritional regimen in terms of qualitative and quantitative indicators is shown.

[Working ability of elderly university teachers under the combined influence of breathing exercises and peptide bioregulator «Cortexin¼.]

The two-week use of special breathing exercises in combination with the Cortexin peptide bioregulator optimizes the functional state and increases the professional performance of older teachers more effectively compared to the single use of a pharmacological preparation. The maximum effect is noted immediately after the end of the course use of special breathing exercises and the peptide bioregulator and lasts for two months. The results obtained open up prospects for the use of breathing exercises to enhance and prolong the nootropic drugs and antihypoxants antistress and geroprotective effects.

[The influence of self-massage combined with drug Noopept on the professional performance of teachers older.]

It is shown that the two-week use of self-massage of the head and neck in combination with the pharmacological drug Noopept improves the functional state and increases the professional performance of elderly teachers compared to single use of nootropic drug. The greatest increase in the functional state and professional performance was noted immediately after the course of self-massage of the head and neck in combination with the pharmacological drug Noopept. The combined effect of self-massage and nootropic drug on the functional state and professional performance indicators are maintained for 1-2 months, and by the end of the third month they are approaching the initial values.

[The pathogenetic approach to the development of tools and methods for the improvement of statokinetic stability in the operators of aerospace systems].

The objective of the present study was to estimate the efficacy of the tools and methods for the optimization of the activity of the central nervous system (CNS) and analyzers involved in the maintenance of the statokinetic (SK) stability in man. To this effect, we evaluated the outcome of bemitil treatment during 10 days with and without A.I. Yarotsky test and the influence of these procedures on the pathophysiological characteristics of selected elements of the work of operators of aerospace systems. Based on the data obtained in the study, the tools and methods have been developed that allow the efficacy and quality of certain aspects of the operators' activity to be improved, viz. general working capacity under conditions requiring enhanced statokinetic stability, self-confidence, emotional and somatic comfort.

[Complex assessment of inhacort effectiveness in bronchial asthma]. / Kompleksnaia otsenka éffektivnosti ingakorta pri lechenii bol'nykh bronkhial'noi astmoi.

AIM: To investigate efficiency of inhacort in long-term (6 months to 2 years) treatment of bronchial asthma (BA). MATERIALS AND METHODS: 67 inpatients and 65 outpatients with moderate BA were divided into two groups. 96 patients of group 1 had received standard combined treatment without glucocorticosteroids (GCS), 36 patients of group 2 had received GCS. Inpatients were given inhacort in a dose 1000 micrograms/day, outpatients took inhacort in a daily dose 500 micrograms/day. The examination scheme included assessment of external respiration function (ERF), blood hydrocortisone, sputum rheology and diagnosis of candidosis. RESULTS: Inhacort treatment has reduced frequency of asphyxia attacks 2.5-fold 30 and 25% of the patients stopped taking sympathomimetics and GCS, respectively. None of the patients had asphyxia as a status. ERF, sputum viscosity improved, hydrocortisone secretion was unchanged. Only 3.8% of the patients developed oral candidosis. CONCLUSION: Inhacort in a dose 1 mg controls BA. 73% of the patients treated outpatiently had no need in hospitalization.

[A complex evaluation of the efficacy of aldecin in treating bronchial asthma patients]. / Kompleksnaia otsenka éffektivnosti al'detsina pri lechenii bol'nykh bronkhial'noi astmoi.

AIM: Study of efficiency of inhalation glucocorticosteroid Aldecine. MATERIALS AND METHODS: A 4-week trial of 30 patients with bronchial asthma. Treatment results were evaluated by clinical symptoms, demand of inhalation sympathomimetics, external respiration, viscosity and elasticity of bronchial secretion, concentrations of hydrocortisone and thyroid hormones. RESULTS: Aldecine produced a good clinical effect, improved external respiration, allowed to reduce doses of inhalation beta-adrenomimetics. No deterioration of either bronchial secretion rheology or inhibition of adrenal and thyroid function was seen. Candidiasis was clinically negligible. CONCLUSION: Aldecine proved highly effective and tolerable in patients with bronchial asthma.

[The effect of salben on the rheological properties of the bronchial secretion]. / Vliianie sal'bena na reologicheskie svoistva bronkhial'nogo sekreta.

AIM: Assessment of the effect of a new Russian selective sympathomimetic salben (powder for inhalations) on bronchial secretion viscosity and adhesion. MATERIALS AND METHODS: Salben or placebo (sodium bensoate) were given to 82 and 30 patients (control) with bronchial asthma, respectively. The response was assessed by clinical, laboratory and instrumental findings. RESULTS: A statistically significant (p < 0.05) reduction of the viscosity and adhesion (by 15 and 20%, respectively) was noted in the salben group which also demonstrated improved external respiration. CONCLUSION: Salben induced positive effect on bronchial secretion viscosity and adhesion.

[The determination of sialidase activity in the blood serum and saliva]. / Opredelenie aktivnosti sialidazy v syvorotke krovi i sliune.

A method for sialidase (neuraminidase; EC 3.2.1.18) measurements in the blood serum and saliva has been developed. The activity of this enzyme in the blood serum manifests in repeated intensive stressogenic exposures, malignant tumors and acute respiratory diseases. Salivary sialidase activity is elevated in the patients with multiple dental caries.

[Determination of free and bound forms of sialic acids in biologic objects]. / Opredelenie svobodnoi i sviazannykh form sialovykh kislot v biologicheskikh ob"ektakh.

A method for simultaneous measurements of free, oligomer-bound and protein-bound sialic acids in the blood serum, saliva, and tissue homogenates is offered. The results of these parameters measurements after stressogenic exposures and in some diseases are presented.

[Use of anodization for the protective and surface finishing of dental instruments made of aluminum alloys]. / Primenenie ématalirovaniia dlia zashchitno-dekorativnoi otdelki zubovrachebnykh nakonechnikov iz aliuminievykh splavov.

Based on a study of thickness, quality and corrosion resistance of anodized films deposited on aluminium alloys D16T and B95 depending on electrolyte composition and oxidation parameters the optimum composition and operating process for the above alloys are established. The oxidation parameters affect in a much less degree the quality of films deposited on the alloy B95 thus permit recommending it for production of medical instruments.

[Collagen and glycosaminoglycan content of tissues under emotional effects in hypothalamic zones]. / Soderzhanie kollagena i glikozaminoglikanov v tkaniakh pri vosdeistviiakh na émotsiogennye zony gipotalamusa.

The content of carbohydrate-containing bipolymers in the tissues of aorta, skin and blood serum of rabbits was studied under the effect of electrostimulation of supraoptical, ventromedial and medial mammillary nuclei of hypothalamus. The stimulation of supraoptical and ventromedial nuclei of hypothalamus is shown to be accompanied by an increase in the amount of collagen, glycosaminoglycans, sialic acids and glycoproteins which was estimated by the content of protein and hexosamines. Stimulation of the medial mammillary nucleus causes opposite changes.