Relación entre educación, envejecimiento y deterioro cognitivo en una muestra de adultos mayores de Arequipa / Relationship between education, aging and cognitive impairment in a sample of older adults in Arequipa

Los estudios epidemiológicos muestran una clara relación entre el nivel educativo y la presencia de deterioro cognitivo en poblaciones envejecidas. En nuestro medio no existen investigaciones que aborden esta problemática por lo que pretendemos realizar una primera aproximación a las consecuencias del envejecimiento y el bajo nivel educativo sobre los procesos cognitivos. Para esto evaluamos a 280 sujetos adultos mayores de tres distritos de la ciudad Arequipa con el Examen Mental Abreviado (Mini Mental) y un cuestionario de variables sociodemográficas. Nuestros resultados muestran una relación significativa entre la edad y el deterioro cognitivo observándose puntajes más bajos en sujetos con mayor edad; además observamos que los sujetos con mayor nivel educativo muestran puntajes más altos. Estas primeras aproximaciones al deterioro cognitivo en nuestro medio ponen de relieve la importancia de la implementación de políticas socioeducativas eficaces que permitan el acceso a la educación a la mayoría de nuestra población.

The epidemiologic studies of cognitive decline show a clear relationship between the educational level and the presence of cognitive deterioration in aged populations. In our city there are not investigations that approach this problem for what we try to carry out a first approach to the consequences of the aging and the educational low-level on the cognitive processes. For this we evaluated 280 old age fellows of three districts of the city of Arequipa with the Mini Mental State Examination and a questionnaire of sociodemographic variables. Our results show a significant relationship between the age and the cognitive deterioration being observed in lower score in subject with more age; we also observe that those subject with more educational level show higher score. These first approaches to the cognitive deterioration in our city put of relief the importance of the implementation of effective political programs that allow the access to the education to most of our population.

Pregnancy in patients with mild thyroid abnormalities: maternal and neonatal repercussions.

A prospective study was undertaken during pregnancy in 120 euthyroid women presenting with mild thyroid abnormalities (TA): 11 with a past history of thyroid disorder, 44 with goiter, 20 with nodules, and 45 with thyroid autoantibodies. The aims of the study were to assess whether the pattern of thyroid alterations during gestation was different in women with TA compared to that in healthy control pregnant subjects and to evaluate possible obstetrical and neonatal repercussions. The overall prevalence of underlying subtle thyroid abnormalities in the cohort was 17%, probably as the result of the environmental moderately low iodine intake. Despite the intrinsic heterogeneity of the four groups of women with TA, the adaptation of the thyroid to the stress of pregnancy was different from that of the control subjects. Noteworthy were 1) the marked elevation of serum thyroglobulin in women with past history of thyroid disorder, goiter and thyroid nodules; 2) the increase in goiter size in a third of the goitrous women, associated with biochemical evidence of functional stimulation of the gland; 3) the indirect evidence of partial thyroidal autonomy in goitrous patients; and 4) the increase in the number and size of thyroid nodules during gestation. Taken together, the data indicated that pregnancy was associated with a greater thyroidal risk in patients with TA compared to healthy subjects. In relation to thyroid autoimmunity, most patients remained euthyroid during gestation, but in a few cases, TSH was elevated at delivery, suggesting diminished thyroidal reserve. Also, 40% of newborns from mothers with thyroid autoimmunity had elevated thyroid peroxidase antibody titers at birth, and there was a highly significant correlation between maternal and neonatal thyroid peroxidase antibody titers. Finally, thyroid autoimmunity was clearly associated with an increased risk of spontaneous abortion (13.3 vs. 3.3%; P less than 0.001). Thyroid function in newborns from mothers with TA was normal and not different from that in controls; similarly, obstetrical features were similar in patients with TA and control subjects. In conclusion, pregnancy is associated with a greater thyroidal risk in women with TA, thereby emphasizing a potential link between pregnancy and thyroid disorders. It is recommended that patients with known, even subtle, thyroid abnormalities be closely monitored during pregnancy, in particular those with a goiter, nodules, or thyroid autoimmunity, especially in areas with a moderately low iodine intake, where the prevalence of mild thyroid disturbances is high.

Water intoxication associated with nephrogenic diabetes insipidus secondary to lithium: case report.

In the psychiatric population, psychogenic polydipsia leading to water intoxication and nephrogenic diabetes insipidus secondary to lithium therapy are both well-recognized entities. A case is reported of the apparently unusual combination of these two conditions, where lithium probably not only has caused the nephrogenic diabetes insipidus, but might also have contributed to the state of psychogenic polydipsia.