RESUMO
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Assuntos
Publicações Periódicas como Assunto/história , Aniversários e Eventos Especiais , Políticas EditoriaisRESUMO
In a multicentre, double-blind, randomized, parallel group clinical trial, the efficacy and tolerability of flutrimazole 1% dermal cream were compared with those of a reference compound, clotrimazole 1% dermal cream, applied topically twice daily for 4 weeks in patients with clinically and mycologically diagnosed fungal infection of the skin. A total of 484 patients were included in the study (244 patients received flutrimazole cream and 240 clotrimazole cream). According to an intention to treat analysis of the data, there was no difference between the treatments in terms of the rate of mycological cure after 4 weeks: 79% of patients in the clotrimazole group and 80% of patients in the flutrimazole group were mycologically cured (P = 0.83). From a safety point of view, flutrimazole and clotrimazole were well tolerated and the overall incidence of adverse reactions (mainly mild local reactions such as irritation or burning sensation) was 7%. This study shows that, in the treatment of fungal infections of the skin, topically applied flutrimazole has good efficacy, similar to that of clotrimazole, and is well tolerated.
Assuntos
Clotrimazol/análogos & derivados , Clotrimazol/administração & dosagem , Dermatomicoses/tratamento farmacológico , Administração Tópica , Adolescente , Adulto , Idoso , Antifúngicos/administração & dosagem , Clotrimazol/efeitos adversos , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Eritema Nodoso/patologia , Dermatoses do Pé/patologia , Criança , Feminino , Humanos , MasculinoRESUMO
A patient with keratoderma palmoplantaris striata is presented. In the family tree there are 36 relatives affected to a varying degree. The familial incidence is the largest reported in the literature reviewed. The response to etretinate was excellent, controlling the lesions with minimal side-effects.
Assuntos
Ceratodermia Palmar e Plantar/genética , Adulto , Etretinato/uso terapêutico , Humanos , Ceratodermia Palmar e Plantar/tratamento farmacológico , MasculinoRESUMO
After a brief introduction about the classification and clinicopathological findings of acanthosis nigricans, we present a clinical case of the familial type of acanthosis nigricans in a woman with lesions beginning in childhood and with three family members affected. We comment the characteristics that permit us to individualize this condition from the other forms of benign acanthosis nigricans.
Assuntos
Acantose Nigricans/genética , Acantose Nigricans/tratamento farmacológico , Acantose Nigricans/patologia , Adulto , Feminino , Humanos , Salicilatos/uso terapêutico , Ácido Salicílico , Tretinoína/uso terapêuticoRESUMO
A case of delayed onset (17 years) progressive symmetric erythrokeratodermia is presented. The treatment with etretinate initially improved the clinical picture, but it had to be discontinued because of personality changes, particularly depressive crisis. In addition, clinical manifestations, histology, kinetics and ultrastructural changes in this condition are also commented on.
Assuntos
Dermatite Esfoliativa/tratamento farmacológico , Etretinato/uso terapêutico , Ceratose/tratamento farmacológico , Dermatite Esfoliativa/patologia , Etretinato/efeitos adversos , Humanos , Ceratose/patologia , Masculino , Pessoa de Meia-IdadeRESUMO
Se presenta un caso de paniculitis en forma de banda subcutánea, infiltrada y con formaciones nodulares, localizada exclusivamente a nivel de brazo en una mujer de 34 años, con historia familar de tuberculosis e hiperergia tuberculínica. El estudio histológico correspondía a una vasculitis nodular, y la respuesta al tratamiento tuberculostático fue satisfactoria. Los autores destacan la excepcional forma de manifestación clínica y acepatan la unificación de la denominación clínica e histopatológica de la vasculitis nodular para las formas asociadas o no a hiperergia frente al bacilo tuberculoso.
