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1.
Appl Radiat Isot ; 179: 110018, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34749092

RESUMO

Glioblastoma multiforme is the most common and aggressive brain tumor and it is difficult to treat with conventional surgery, chemotherapy, or radiation therapy. An alternative treatment is boron neutron capture therapy which requires an energy modulated beam of neutrons and a10B drug capable of adhering to the tumor. In this work, MCNP6 Monte Carlo code was used to evaluate the effect on the neutron spectrum by placing two filters along the radial beam tube of the TRIGA Mark III nuclear reactor of ININ in Mexico. Every filter was made with the same amount and type of materials: Steel and Graphite for filter 1 and Cadmium, Aluminum, and Cadmium (Cd + Al + Cd) for filter 2. Two cases were analyzed for each filter as follows: Case A for filter 1 was considering 30 cm of steel and 30 cm of graphite, while for case B, the dimensions of filter 1 were 15 cm of steel, 15 cm of graphite, 15 cm of steel and 15 cm of graphite. Cases A and B for filter 2 were analyzed considering the same dimensions and amount of materials. The work was in the aim to produce epithermal neutrons for boron neutron capture therapy. Neutron spectra were calculated at three sites along the beam tube and two sites outside the beam tube; here, the ambient dose equivalent, the personal dose equivalent, and the effective doses were also estimated. At a distance of 517 cm of core, in case B, results in an epithermal-to-thermal neutron fluence ratio of 30.39 was obtained being larger than the one recommended by the IAEA of 20.


Assuntos
Terapia por Captura de Nêutron de Boro/métodos , Neoplasias Encefálicas/radioterapia , Glioblastoma/radioterapia , Nêutrons , Humanos , Método de Monte Carlo , Reatores Nucleares
2.
Appl Radiat Isot ; 161: 109129, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32250840

RESUMO

Responses of a novel passive neutron area monitor, named CubBonner, were calculated. The responses were estimated for sixty monoenergetic neutrons, from 10-9 to 20 MeV, with the MCNP5 code. The CubBonner is a cubic polyethylene moderator and a gold foil as thermal neutron detector. The ambient dose equivalent response was calculated for three cubes (5″, 8″ and 10" side) with the gold foil at the cube's centers. The moderator cube having the best ambient dose equivalent response was used to estimate the neutron fluence and the 197Au(n,γ) responses per history. The ambient dose response per unit mass of gold was compared with the response of the Berthold LB 6411 active neutron area monitor, and the response for the (n,γ) reaction in the gold foil was compared with the evaporation photo neutrons produced in linear accelerators for radiotherapy.

3.
Appl Radiat Isot ; 139: 46-52, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29704705

RESUMO

The characteristics of photons and neutrons produced during the interaction between a monoenergetic (12 and 18 MeV) electron beam and a tungsten scattering foil enclosed into a 10 cm-thick tungsten shell have been determined using Monte Carlo methods. This model was used aiming to represent a linac head working in electron-mode for cancer treatment. Photon and neutron spectra were determined around the scattering foil and to 50 and 100 cm below the electron source. Induced photons are mainly produced along the direction of the incoming electron beam. On the other hand, neutrons are produced in two sites, mainly in the inner surface of the linac head and in less extent in the scattering foil. The neutron spectra are evaporation neutrons which are emitted isotropically from the site where are produced leaking out from the linac head, reaching locations were the patient is allocated.

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