FEVER: an interactive web-based resource for evolutionary transcriptomics across fishes.

Teleost fish represent one of the largest and most diverse clades of vertebrates, which makes them great models in various research areas such as ecology and evolution. Recent sequencing endeavors provided high-quality genomes for species covering the main fish evolutionary lineages, opening up large-scale comparative genomics studies. However, transcriptomic data across fish species and organs are heterogenous and have not been integrated with newly sequenced genomes making gene expression quantification and comparative analyses particularly challenging. Thus, resources integrating genomic and transcriptomic data across fish species and organs are still lacking. Here, we present FEVER, a web-based resource allowing evolutionary transcriptomics across species and tissues. First, based on query genes FEVER reconstructs gene trees providing orthologous and paralogous relationships as well as their evolutionary dynamics across 13 species covering the major fish lineages, and 4 model species as evolutionary outgroups. Second, it provides unbiased gene expression across 11 tissues using up-to-date fish genomes. Finally, genomic and transcriptomic data are combined together allowing the exploration of gene expression evolution following speciation and duplication events. FEVER is freely accessible at https://fever.sk8.inrae.fr/.

A lamprey neural cell type atlas illuminates the origins of the vertebrate brain.

The vertebrate brain emerged more than ~500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular origins, we established a spatially resolved cell type atlas of the entire brain of the sea lamprey-a jawless species whose phylogenetic position affords the reconstruction of ancestral vertebrate traits-based on extensive single-cell RNA-seq and in situ sequencing data. Comparisons of this atlas to neural data from the mouse and other jawed vertebrates unveiled various shared features that enabled the reconstruction of cell types, tissue structures and gene expression programs of the ancestral vertebrate brain. However, our analyses also revealed key tissues and cell types that arose later in evolution. For example, the ancestral brain was probably devoid of cerebellar cell types and oligodendrocytes (myelinating cells); our data suggest that the latter emerged from astrocyte-like evolutionary precursors in the jawed vertebrate lineage. Altogether, our work illuminates the cellular and molecular architecture of the ancestral vertebrate brain and provides a foundation for exploring its diversification during evolution.

Buenas prácticas en la visita domiciliaria integral en atención primaria chilena / Good practices in the integral home care visits in Chilean primary care

La atención del paciente en el domicilio, constituye una excelente alternativa de salud, con múltiples beneficios demostrados, en especial para un grupo de pacientes con dificultades de acceso. El objetivo principal de una visita domiciliaria integral (VDI) es favorecer el autocuidado en salud, ofreciendo una atención de salud centrada en la persona y su familia, considerando las variables biopsicosociales, facilitando el acceso a la atención y redes de apoyo, mejorando así su calidad de vida y potenciando su recuperación y rehabilitación. Una VDI, consta de tres etapas: planificación previa de la visita en base a los motivos de consulta principales; la ejecución de la visita en sí, en la cual se busca generar el vínculo, observar el ambiente familiar y priorizar los problemas biopsicosociales para lograr cambios e intentar mejorar la situación; y por último, realizar un monitoreo y evaluación del caso. El objetivo de este artículo es brindar una breve sistematización al equipo de salud de atención primaria de salud, para que puedan comprender la relevancia y el proceso del desarrollo de una VDI, sumado a síntesis de buenas prácticas para el trabajo eficiente en equipo

Home care visits are an excellent chance of health attention, with multiple proven benefits, specially, for a group of patients with access difficulties. The main objective of an integral home care visit is to promote self-care in health, offering a person and family centered care, taking in consideration biopsychosocial variables, facilitating the access to healthcare systems and support networks, improving their quality of life and enhancing their recovery and rehabilitation. An integral home care visit, has mainly three stages: planification of the visit with anticipation according to the main complaints; the execution of the visit itself, which seeks to create an initial bond, observe the family and domestic environment, prioritize biopsychosocial problems to achieve changes and try to improve the situation; and at last, to monitor and evaluate the case. The objective of this article is to provide a brief systematization to the primary health care team, so that they can understand the relevance and the process of developing an integral home care visit, added to a synthesis of good practices to achieve an efficient interdisciplinary team work.