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1.
Environ Toxicol Pharmacol ; 87: 103703, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34265456

RESUMO

Potential endpoint biomarkers were evaluated in the assessment of exposure to triazoles, in the southern region of Minas Gerais, Brazil. Volunteers were divided into three groups: occupationally exposed and rural residents (n = 21), non-occupationally exposed and rural residents (n = 35) and non-occupationally exposed and urban residents (n = 30). Of all endpoints evaluated, plasma concentration of androstenedione (p < 0.001) and glycine-conjugated bile acids presented statistical differences in the three studied groups (p < 0.05). However, our findings concerning oxidative stress and testosterone levels, plus that related to unconjugated and taurine conjugated bile acids, suggested that more studies are necessary to evaluate their potential as biomarkers for triazole exposure, as statistical significance was not attained between the groups. Our human population data contributes to the development of triazole exposure risk assessment with respect to these potential effect biomarkers, in potentially vulnerable groups and individuals.


Assuntos
Disruptores Endócrinos , Fungicidas Industriais , Exposição Ocupacional , Triazóis , Adulto , Androstenodiona/sangue , Ácidos e Sais Biliares/sangue , Ácidos e Sais Biliares/metabolismo , Monitoramento Biológico , Biomarcadores/sangue , Glicina/metabolismo , Humanos , Pessoa de Meia-Idade , Estresse Oxidativo , População Rural , Testosterona/sangue , População Urbana
2.
J Chromatogr A ; 1586: 9-17, 2019 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-30528767

RESUMO

The development and validation of an innovative, simple, rapid, selective and sensitive vortex-assisted liquid-liquid microextraction-gas chromatography- mass spectrometry (VALLME-GC/MS) method to seven triazole fungicides in urine is reported. The confidence parameters were exhaustive evaluated and linearity (r > 0.99), precision (below 15%, to quality controls, and 20%, to lower limit of quantification), accuracy and robustness were adequate for the analysis of cyproconazole, epoxiconazole, metconazole, tebuconazole, triadimenol, propiconazole and triadimefon. To assess the applicability of the method, analyses were performed in volunteers exposed to triazoles in the last 30 days. The method demonstrated satisfactory analytical performance, with sufficient detectability to be applied as a potential tool to biomonitoring individuals exposed to the seven evaluated fungicides.


Assuntos
Monitoramento Ambiental/métodos , Cromatografia Gasosa-Espectrometria de Massas/métodos , Microextração em Fase Líquida/métodos , Resíduos de Praguicidas/urina , Triazóis/urina , Humanos , Resíduos de Praguicidas/isolamento & purificação , Triazóis/isolamento & purificação
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